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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by elleff on June 16, 2004, at 18:50:30
Dear All
I would be very interested to hear from anyone about their experiences on Tianeptine (Stablon). There is certainly literature to support it's effectiveness as an antidepressant, as well as being effective in ADD (eg http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15034228) and in asthma (eg http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9807972).
HappySmurf wrote glowingly in April about it's antidepressant effects when combined with Selegiline. If you are now reading this HappySmurf could you let us know how this is going for you.
Also, if anyone who has had depression and asthma, or an asthma related condition such as allergic rhinitis or eczma, I'd be very keen to hear how it affected them.
Thanks in advance to any responders.
regards
elleff
Posted by Ktemene on June 17, 2004, at 1:53:49
In reply to Tianeptine experiences?HappySmurf and Others, posted by elleff on June 16, 2004, at 18:50:30
Hi Elleff,
I'm afraid I don't have any experience with Tianeptine, although it sounds like a fascinating med. But I did start low dose selegiline recently, partly because I read so many positive reports about it on this board. Your posts were especially helpful. Would you have the time to give us an update on your experience with selegiline? As I recall, you found fairly low dose selegiline very helpful for depression and ADD, and you recommended taking it with l-phenylalanine and vitamin B6 and chromium chelate. Are you still doing well on selegiline? Are you taking anything to augment the selegiline?
Thanks,
Ktemene
Posted by Pluto on June 17, 2004, at 3:18:27
In reply to Tianeptine experiences?HappySmurf and Others, posted by elleff on June 16, 2004, at 18:50:30
Hi,
I tried stablon once in my past, and I have nothing good to say about it. Two tablets of 12.5mg turned me into an intoxicated state, that was disturbing and after a week or so, I left that stuff for good.
Anyway, I have heard some positive results from stablon like it helped some asthmatic depressives. For me, it was nothing but an analogy of alcohol, or alcohol in a pill form.
PLS
Posted by elleff on June 17, 2004, at 5:14:35
In reply to Re: Tianeptine experiences?HappySmurf and Others, posted by Ktemene on June 17, 2004, at 1:53:49
> Hi Elleff,
>
> I'm afraid I don't have any experience with Tianeptine, although it sounds like a fascinating med. But I did start low dose selegiline recently, partly because I read so many positive reports about it on this board. Your posts were especially helpful. Would you have the time to give us an update on your experience with selegiline? As I recall, you found fairly low dose selegiline very helpful for depression and ADD, and you recommended taking it with l-phenylalanine and vitamin B6 and chromium chelate. Are you still doing well on selegiline? Are you taking anything to augment the selegiline?
>
> Thanks,
> KtemeneHi Ktemene
Yes I am still taking selegiline. In fact it was through reading about HappySmurf's combination of selegiline and tianeptine that I became somewhat interested in the latter. In my further reading about tianeptine I discovered that it has some interesting anti-inflammatory properties, which are presumably the basis of it's anti-asthmatic effects. Whilst I don't have asthma, practically everyone else in my family does, and I have quite bad allergic rhinitis. I would be very interested in a medication that worked on all three at once (ie. depression, ADD, and allergies) - reflecting maybe an underlying common pathophysiology.
Back to your questions however. Yes I'm still taking Selegiline combined with 500mg - 1000mg of DL-phenylalanine, 50mg of pyridoxine, and 200mcg of chelated chromium. Through various stages of experimentation I have found that 2.5mg of selegiline twice daily, taken sublingually, works best for me. I take the phenylalanine as 500mg once or twice daily on an empty stomach. I think the chromium has some augmenting effects for me. I couldn't be certain about the pyridoxine, which I take only because others on the board have previously recommended it as part of this type of regime.
I think this regime has maintained efficacy for me for over one year now. The only thing it doesn't work for is my rhinitis - so I was thinking of trying tianeptine and had wondered whether any others had good experiences to report.
regards
elleff
Posted by LastDyingWish on June 18, 2004, at 0:12:20
In reply to Re: Tianeptine experiences?HappySmurf and Others, posted by elleff on June 17, 2004, at 5:14:35
Hey ellef
Would you be so kind to elaborate on your selegiline experience. I have been trying to get my doc to prescribe it but he is leery of its efficacy.
Can you tell me how it makes you feel ? Any overstimulation and if so what does it feel like ?
Cognitive benefits ? Do you feel healthy or drugged ?
I hope this doesnt come off as grilling you for information, Iam just very interested.
Any info would be appreciated
JS
Posted by Ktemene on June 18, 2004, at 0:45:12
In reply to Re: Tianeptine experiences?HappySmurf and Others, posted by elleff on June 17, 2004, at 5:14:35
Posted by elleff on June 18, 2004, at 8:35:28
In reply to Re: Tianeptine experiences?HappySmurf and Others, posted by LastDyingWish on June 18, 2004, at 0:12:20
> Hey ellef
> Would you be so kind to elaborate on your selegiline experience. I have been trying to get my doc to prescribe it but he is leery of its efficacy.
> Can you tell me how it makes you feel ? Any overstimulation and if so what does it feel like ?
> Cognitive benefits ? Do you feel healthy or drugged ?
> I hope this doesnt come off as grilling you for information, Iam just very interested.
> Any info would be appreciated
> JSHi LastDyingWish
My experience of selegiline alone is that it is mildly stimulatory at this dose, meaning that I feel a more energised, focussed, & perhaps slightly more assertive. The subjective experience is certainly milder than 5mg of dexamphetamine and isn't particularly euphoric. I feel alerted, cognitively a bit sharper, and not notably drugged.
Bear in mind that 2.5mg sublingually is probably equivalent to 10mg or more orally. Indeed studies have been done with a specially formulated ("Zydis wafer") form of selegline optimized for buccal absorption which show that in this form 1.25mg of selegiline is roughly equivalent to 10mg of selegiline taken orally ( see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14628189)
On top of this the phenylalanine seems to add a dimension of general well-being, which I think of as being principally an anti-depressant effect. I would say the feeling is mildly anxiolytic and gives a feeling of confidence. I think this is enhanced somewhat by chromium. I think as well that the chromium has diminished my level of carbohydrate and chocolate craving.
regards
elleff
Posted by LastDyingWish on June 18, 2004, at 12:00:51
In reply to Re: Tianeptine experiences?HappySmurf and Others » LastDyingWish, posted by elleff on June 18, 2004, at 8:35:28
Posted by StevenInLB on June 29, 2004, at 2:57:54
In reply to Tianeptine experiences?HappySmurf and Others, posted by elleff on June 16, 2004, at 18:50:30
I have tried Tianeptine on and off a few times over the past year. I have found it to be most benign of the antidepressants I have tried (Prozac, Effexor, Welbutrin, Celexa, Zoloft, Remeron). The side-effects are practically nil compared to the SSRIs. The only real side effects I noticed were some increased heart rate and a slight transient dizzyness at times. Sometimes I would feel floored for 10 minutes shortly after taking a dose; this would pass quickly though. The effects of the drug are ususual. I found it to be highly anxiolytic, which one poster refered to as an intoxicated feeling. This occurs very rapidly as it would with a benzo. I would not say it is like alcohol intoxication; it is a very clean relaxation, without sleepiness. I also found my social anxiety and verbal fluency were helped by tianeptine. The recommended dose of 3x per day I felt was too high, and I found 1-2 per day was enough. Paradoxically, taking more than 2 would make me anxious. I have never felt that it is a great antidepressant, but definitely a good alternative to benzos for anxiety. I however have never taken it for an extended period.
I have stopped Tianeptine since I am currently starting Lamictal in monotherapy which is supposed to be a good mood stabilizer with antidepressant properties. I still consider Tianeptine to be a great option especially for people who become manic/anxious on the ssri's as I do. Overall it is a very clean drug, without the emotional blunting, sexual side effects, and discontinuation symptoms/withdrawal of the ssri's. It is one of the few antidepressants I would consider taking again.
> Dear All
>
> I would be very interested to hear from anyone about their experiences on Tianeptine (Stablon). There is certainly literature to support it's effectiveness as an antidepressant, as well as being effective in ADD (eg http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15034228) and in asthma (eg http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9807972).
>
> HappySmurf wrote glowingly in April about it's antidepressant effects when combined with Selegiline. If you are now reading this HappySmurf could you let us know how this is going for you.
>
> Also, if anyone who has had depression and asthma, or an asthma related condition such as allergic rhinitis or eczma, I'd be very keen to hear how it affected them.
>
> Thanks in advance to any responders.
>
> regards
>
> elleff
Posted by elleff on June 30, 2004, at 21:51:27
In reply to Re: Tianeptine experiences?HappySmurf and Others, posted by StevenInLB on June 29, 2004, at 2:57:54
Dear StevenInLB
Thank you very much for your reply. I am certainly encouraged to try it.
regards
elleff
> I have tried Tianeptine on and off a few times over the past year. I have found it to be most benign of the antidepressants I have tried (Prozac, Effexor, Welbutrin, Celexa, Zoloft, Remeron). The side-effects are practically nil compared to the SSRIs. The only real side effects I noticed were some increased heart rate and a slight transient dizzyness at times. Sometimes I would feel floored for 10 minutes shortly after taking a dose; this would pass quickly though. The effects of the drug are ususual. I found it to be highly anxiolytic, which one poster refered to as an intoxicated feeling. This occurs very rapidly as it would with a benzo. I would not say it is like alcohol intoxication; it is a very clean relaxation, without sleepiness. I also found my social anxiety and verbal fluency were helped by tianeptine. The recommended dose of 3x per day I felt was too high, and I found 1-2 per day was enough. Paradoxically, taking more than 2 would make me anxious. I have never felt that it is a great antidepressant, but definitely a good alternative to benzos for anxiety. I however have never taken it for an extended period.
>
> I have stopped Tianeptine since I am currently starting Lamictal in monotherapy which is supposed to be a good mood stabilizer with antidepressant properties. I still consider Tianeptine to be a great option especially for people who become manic/anxious on the ssri's as I do. Overall it is a very clean drug, without the emotional blunting, sexual side effects, and discontinuation symptoms/withdrawal of the ssri's. It is one of the few antidepressants I would consider taking again.
>
> > Dear All
> >
> > I would be very interested to hear from anyone about their experiences on Tianeptine (Stablon). There is certainly literature to support it's effectiveness as an antidepressant, as well as being effective in ADD (eg http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15034228) and in asthma (eg http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9807972).
> >
> > HappySmurf wrote glowingly in April about it's antidepressant effects when combined with Selegiline. If you are now reading this HappySmurf could you let us know how this is going for you.
> >
> > Also, if anyone who has had depression and asthma, or an asthma related condition such as allergic rhinitis or eczma, I'd be very keen to hear how it affected them.
> >
> > Thanks in advance to any responders.
> >
> > regards
> >
> > elleff
>
>
This is the end of the thread.
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