![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Tepiaca on January 22, 2004, at 22:21:15
Does anybody have used this combo for SP ?
My doctor has aded Epival 500 mg/day. He says this is gonna help me to feel less anxious among people.What do you think about this combo ??
Im not bipolar , Why do you think he´s giving me this kind of medicine ?
Im starting the this medicine tomorrow morning
Hope this help meany thougths are welcome
Tep
Posted by Karen Moore on January 22, 2004, at 23:22:06
In reply to Nardil + Valproi Acid (Depakote,Epival )..anybody, posted by Tepiaca on January 22, 2004, at 22:21:15
Well...it does seem strange that he's trying this even though you're not bipolar. BUT he may just be ahead of the curve. Depakote can work really well for dysphoric mania/mixed states. I know some pdocs in my area have been successfully using Neurontin, also a "mood stabilizer" like Depakote, for treatment of anxiety. I was on Depakote last year and found it definitely mentally relaxing, with and without Nardil. If it's to treat anxiety/SP, you might even be able to get away with a really low dose and thus avoid any side-effects!
Good luck,
KM
Posted by rod on January 23, 2004, at 5:31:44
In reply to Nardil + Valproi Acid (Depakote,Epival )..anybody, posted by Tepiaca on January 22, 2004, at 22:21:15
> Does anybody have used this combo for SP ?
> My doctor has aded Epival 500 mg/day. He says this is gonna help me to feel less anxious among people.
>
> What do you think about this combo ??
>
> Im not bipolar , Why do you think he´s giving me this kind of medicine ?
> Im starting the this medicine tomorrow morning
> Hope this help me
>
> any thougths are welcome
>
> TepHe gives it, because its a gabaergic drug. Somewhat similar to a benzo (tranquilizer). I also thought about it, but I also do take Lamictal and this two dont mix very well.
good luck with it.
greetings to mexico!
Roland
Posted by Tepiaca on January 23, 2004, at 17:43:28
In reply to Re: Nardil + Valproi Acid (Depakote,Epival ) » Tepiaca, posted by Karen Moore on January 22, 2004, at 23:22:06
thanks for your input km
I have this question
did you have any weigth gain while on this drug??why did you stop taking it ??
thanks
Posted by Tepiaca on January 23, 2004, at 17:55:35
In reply to Re: Nardil + Valproi Acid (Depakote,Epival )..anyb, posted by rod on January 23, 2004, at 5:31:44
thank you bro
I hope this drug help me more to feel calm and lexx anxious
by the way .... how did you know Im from Mexico?have you read my posts before?
Posted by rod on January 24, 2004, at 6:01:15
In reply to Re: Nardil + Valproi Acid (Depakote,Epival )..anyb » rod, posted by Tepiaca on January 23, 2004, at 17:55:35
> how did you know Im from Mexico?
>
> have you read my posts beforeYes!
Posted by Karen Moore on January 24, 2004, at 19:29:16
In reply to Re: Nardil + Valproi Acid (Depakote,Epival ) » Karen Moore, posted by Tepiaca on January 23, 2004, at 17:43:28
Tepiaca,
Yes, unfortunately I did have some unwanted weight gain on this combination, 15lbs or so. But I also had some other really bizarre medical things going on at the time that were not related to the meds, so cause and effect were somewhat blurred. I stopped it because...well...umm...that's also a little blurry...I guess you could say I'm a classic bipolar sometimess and I had convinced myself that I no longer needed any meds! Not a very good reason, I'm still learning =?
km
P.S. Did your doc give you the usual blood work that goes along with monitoring the valproic acid? It helped me find a dose that was optimal and it did effect my liver, so it's a good idea to monitor. I think most docs do a valproic acid levels check, a liver panel, and a cbc after a week or two.
Posted by Tepiaca on January 24, 2004, at 20:38:07
In reply to Nardil + Valproi Acid (Depakote,Epival )..anybody, posted by Tepiaca on January 22, 2004, at 22:21:15
Today was my second day on this combo.
I dont like how Im feeling right now.
I haven´t have any benefits on anxiety,instead my anxiety is getting just a little worst
But the worst thing is that Im feeling depressed,
I dont have motivation , I dont want to do anything ,not even to write this.mmmm , why is this happen?
do you think I should stay more time on EPIVAL ?
I thought this combo was gonna help me ,but I guess I was wrong
can you help me do some conclucions ?
NArdil increases gaba , so does Epival ,..rigth?
thats mean I dont need to have an increase in the gaba system???
I really dont know anything about this stuff
help this one please
Posted by rod on January 25, 2004, at 6:17:26
In reply to UPDATE ...... I don´t like this..., posted by Tepiaca on January 24, 2004, at 20:38:07
>
> Today was my second day on this combo.
> I dont like how Im feeling right now.
> I haven´t have any benefits on anxiety,instead my anxiety is getting just a little worst
> But the worst thing is that Im feeling depressed,
> I dont have motivation , I dont want to do anything ,not even to write this.
>
> mmmm , why is this happen?
>
> do you think I should stay more time on EPIVAL ?
>
> I thought this combo was gonna help me ,but I guess I was wrong
>
> can you help me do some conclucions ?
>
> NArdil increases gaba , so does Epival ,..rigth?
> thats mean I dont need to have an increase in the gaba system???
> I really dont know anything about this stuff
> help this one please
I cant help you to do some conclusions. Its just your 2nd day on it. If its still this way after a few weeks on a stable dose, I would quit it. In my opinion its much too early to draw any conclusions at all. Epival does much more than just increasing gaba. It also blocks Na channels etc. ...
I guess you feel the antimaniac effect of it.just an example:
...valproic acid (VPA), has a very wide spectrum of clinical activity ...
"Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14573383&dopt=Abstract
Roland
Posted by rod on January 25, 2004, at 6:31:14
In reply to Re: UPDATE ...... I don´t like this... » Tepiaca, posted by rod on January 25, 2004, at 6:17:26
Hmm, I found something interesting
"Valproate and carbamazepine increase prefrontal dopamine release by 5-HT1A receptor activation."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10513560&dopt=AbstractMaybe its because of dopamine release.
Roland
Posted by Tepiaca on February 6, 2004, at 21:20:12
In reply to Nardil + Valproi Acid (Depakote,Epival )..anybody, posted by Tepiaca on January 22, 2004, at 22:21:15
Hello
This is my 15th day on this combo (Nardil 45mg + Epival ER 500mg)The first days my anxiety was worse. My fear became very unbearable . Days have been passing and I think Im better now than I was before this
drug . But only in the field of anxiety.What it refers to depression , Im not very well.
I was feeling better before adding Epival.
I have very low motivation , dont want to leave my house ,I dont want to do anything.
Im having problems writting this message , dont want to do ithere are the results
-Nardil 45mg
Control of anxiety : 60 %
Control of depression: 85%- Nardil 45+ Epival ER 500mg
Control of anxiety : 70 %
Control of depression: 50 %What do you think ?
Can you suggest me something?
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
[email protected]
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.