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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by dragonfly25 on December 29, 2003, at 12:10:30
i am probably going to say this wrong, but doe anyone know of any drugs that increase dopamine and norepinephrine other than; wellbutrin, effexor, and ritalin?
thanx
dragonfly
Posted by Utopia on December 29, 2003, at 13:00:35
In reply to drugs that effect norepinephrine and dopamine??, posted by dragonfly25 on December 29, 2003, at 12:10:30
Hi
Yes, your old generation MAOI's do -
Phenelzine - Nardil
Tranylcypromine - ParnateThe side effects are to be considered - the "Cheese effect" and all that.
Regards
Posted by SLS on December 29, 2003, at 13:01:04
In reply to drugs that effect norepinephrine and dopamine??, posted by dragonfly25 on December 29, 2003, at 12:10:30
> i am probably going to say this wrong, but doe anyone know of any drugs that increase dopamine and norepinephrine other than; wellbutrin, effexor, and ritalin?
> thanx
> dragonflysibutramine
mazindol
- Scott
Posted by dragonfly25 on December 29, 2003, at 13:03:33
In reply to drugs that effect norepinephrine and dopamine??, posted by dragonfly25 on December 29, 2003, at 12:10:30
are these similar to the drugs i mentioned at all? i am not familiar with them.
thx
Posted by dragonfly25 on December 29, 2003, at 13:12:53
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by SLS on December 29, 2003, at 13:01:04
are these used for depression?
> > i am probably going to say this wrong, but doe anyone know of any drugs that increase dopamine and norepinephrine other than; wellbutrin, effexor, and ritalin?
> > thanx
> > dragonfly
>
> sibutramine
> mazindol
>
>
> - Scott
Posted by SLS on December 29, 2003, at 13:16:34
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by dragonfly25 on December 29, 2003, at 13:03:33
> are these similar to the drugs i mentioned at all? i am not familiar with them.
> thxThe drugs that Utopia mentioned, the MAOIs, are proven medications that are worth taking a look at first. The ones that I mentioned are more like Effexor. Sibutramine (Meridia) and mazindol (Mazinor, Sanorex) are both medications that were approved as anti-obesity drugs but that were originally developed as antidepressants.
- Scott
Posted by linkadge on December 29, 2003, at 14:10:16
In reply to drugs that effect norepinephrine and dopamine??, posted by dragonfly25 on December 29, 2003, at 12:10:30
Remeron has more effect on dopamine and norepinephrine than it does on serotonin.
Linkadge
Posted by SLS on December 29, 2003, at 14:17:23
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by linkadge on December 29, 2003, at 14:10:16
> Remeron has more effect on dopamine and norepinephrine than it does on serotonin.
What does it do? Is DA activity downstream increased by the blockade of 5-HT2 receptors?
- Scott
Posted by Alexs on December 29, 2003, at 15:11:29
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by SLS on December 29, 2003, at 14:17:23
STRATERA.
Posted by DSCH on December 29, 2003, at 15:58:16
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by SLS on December 29, 2003, at 13:16:34
> > are these similar to the drugs i mentioned at all? i am not familiar with them.
> > thx
>
> The drugs that Utopia mentioned, the MAOIs, are proven medications that are worth taking a look at first. The ones that I mentioned are more like Effexor. Sibutramine (Meridia) and mazindol (Mazinor, Sanorex) are both medications that were approved as anti-obesity drugs but that were originally developed as antidepressants.
>
>
> - ScottSepracor is in Phase II with a metabolite of R-sibutramine, but is stalled for funding. It is supposed to be a reuptake inhibitor of serotonin, norepinepherine, and dopamine.
DOV has two triple-action RIs in the works too.
Posted by paulk on December 29, 2003, at 19:50:42
In reply to drugs that effect norepinephrine and dopamine??, posted by dragonfly25 on December 29, 2003, at 12:10:30
hows this list: (for even more see:
http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
DA = dopamine NE - norepinephrine
releasers:
dexdrine DA
methamphetamine NE
methylphenidate(ritalin) may have some reuptake effect alsoreuptake blockers:
atomoxetine(stratterra) NE
Provigil (Modafinil) DA
bupropion (Wellbutrin) DA NE
amineptine DAMAOIs:
phenelzine (Nardil) DA NE and SE
tranylcypromine (Parnate) DA NETrycyclics:
Desipramine NE
Trazadone?Others:
adinazolam (Deracyn)NE
amantadine DA
cabergoline (Dostinex) DA
Posted by Laree on December 29, 2003, at 21:08:54
In reply to Re: drugs that effect norepinephrine and dopamine?, posted by paulk on December 29, 2003, at 19:50:42
Adderall
Posted by dragonfly25 on December 29, 2003, at 21:11:51
In reply to Re: drugs that effect norepinephrine and dopamine?, posted by paulk on December 29, 2003, at 19:50:42
thanks that is a very helpful link
dragonfly
Posted by maxx44 on December 29, 2003, at 22:05:12
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by Utopia on December 29, 2003, at 13:00:35
i am known as a 'crusader' for the old ADs. and nardil vet, even a mix of nardil and imipramine--tricky, but works. you may shake, but your cognitive, creative functions soar. the beauty of maoi is their 'broad-spectrum' nature. as the main neuro-transmitters are only partially known, they know a handfull---there may be thousands, well, nardil doesn't care---it will stop the breakdown enzyme (monoamineoxydase)---mao---so even if your depression involves no serotonin, or any specific known or unknown xmitter reuptake problem, nardil will still work---because it's not a rifle aimed at serotonin alone, etc.---it's a shotgun. oddly enough maoi have been shown to promote youthful vigor, hair-growth, libido---even extend lab rat's lives to 30%---and as youths. look at deprenyl---my french neuropsycopharmacoligist told me of it in 1995 as he used it in his paris, france practice, but it was unapproved here. apparently maoi may extend life---in general? perhaps. if it's deprenyl? the newest 'selective' maoi? probably. thanks, and you're welcome.
Posted by linkadge on December 30, 2003, at 6:34:03
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by maxx44 on December 29, 2003, at 22:05:12
Taken from:
http://www.neurotransmitter.net/mirtazapine.html
-----------------------------------------------
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram.Eur J Neurosci 2000 Mar;12(3):1079-95
"Mirtazapine displayed marked affinity for cloned, human alpha2A-adrenergic (AR) receptors at which it blocked noradrenaline (NA)-induced stimulation of guanosine-5'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding. Similarly, mirtazapine showed high affinity for cloned, human serotonin (5-HT)2C receptors at which it abolished 5-HT-induced phosphoinositide generation. Alpha2-AR antagonist properties were revealed in vivo by blockade of UK-14,304-induced antinociception, while antagonist actions at 5-HT2C receptors were demonstrated by blockade of Ro 60 0175-induced penile erections and discriminative stimulus properties. Mirtazapine showed negligible affinity for 5-HT reuptake sites, in contrast to the selective 5-HT reuptake inhibitor, citalopram. In freely moving rats, in the dorsal hippocampus, frontal cortex (FCX), nucleus accumbens and striatum, citalopram increased dialysate levels of 5-HT, but not dopamine (DA) and NA. On the contrary, mirtazapine markedly elevated dialysate levels of NA and, in FCX, DA, whereas 5-HT was not affected. Citalopram inhibited the firing rate of serotonergic neurons in dorsal raphe nucleus, but not of dopaminergic neurons in the ventral tegmental area, nor adrenergic neurons in the locus coeruleus. Mirtazapine, in contrast, enhanced the firing rate of dopaminergic and adrenergic, but not serotonergic, neurons. Following 2 weeks administration, the facilitatory influence of mirtazapine upon dialysate levels of DA and NA versus 5-HT in FCX was maintained, and the influence of citalopram upon FCX levels of 5-HT versus DA and NA was also unchanged. Moreover, citalopram still inhibited, and mirtazapine still failed to influence, dorsal raphe serotonergic neurons. In conclusion, in contrast to citalopram, mirtazapine reinforces frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission. These actions reflect antagonist properties at alpha2A-AR and 5-HT2C receptors." [Abstract]
---------------------------------------------Linkadge
Posted by Sebastian on December 30, 2003, at 12:21:12
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by linkadge on December 29, 2003, at 14:10:16
Abilify
Posted by Sebastian on December 30, 2003, at 12:27:11
In reply to Re: drugs that effect norepinephrine and dopamine??, posted by Sebastian on December 30, 2003, at 12:21:12
Sorry, I think I have that wrong, not sure, I would have to look into it.
Posted by 1980Monroe on December 30, 2003, at 22:10:55
In reply to drugs that effect norepinephrine and dopamine??, posted by dragonfly25 on December 29, 2003, at 12:10:30
Adderall (amphetaine/dexamphetamine) / Dexedrine (dexamphetamine) / Desoxyn (methamphetamine-affects are more strong on dopamine)
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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