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Dr. Bob is Robert Hsiung, MD,
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Posted by Ame Sans Vie on April 12, 2003, at 12:49:20
Does anyone know how much meprobamate is metabolized into your blood from a single 350mg dose of carisoprodol? I think I'm going to ask my pdoc to switch me from Tranxene to Equanil at our next appointment, so I'm just looking for a ballpark figure. TIA
Posted by Larry Hoover on April 12, 2003, at 13:43:00
In reply to Soma/Equanil, posted by Ame Sans Vie on April 12, 2003, at 12:49:20
> Does anyone know how much meprobamate is metabolized into your blood from a single 350mg dose of carisoprodol? I think I'm going to ask my pdoc to switch me from Tranxene to Equanil at our next appointment, so I'm just looking for a ballpark figure. TIA
This is the best I could come up with: "extensive" conversion. This depends on having functional CYP3C19 isozymes.
Ther Drug Monit 1994 Aug;16(4):337-40
Carisoprodol elimination in humans.
Olsen H, Koppang E, Alvan G, Morland J.
Department of Clinical Pharmacology, University Hospital, Tromso, Norway.
The elimination of the muscle relaxant drug, carisoprodol, was examined in 10 healthy volunteers after an oral dose of 700 mg. In nine subjects, carisoprodol was rapidly eliminated, with a mean half-life of 99 +/- 46 min, and extensively converted to meprobamate. Within 2.5 h after carisoprodol intake, meprobamate serum concentrations exceeded those of carisoprodol. Serum levels of meprobamate recorded (15-25 mumol/L) indicate that meprobamate might contribute to the effect(s) of carisoprodol. One subject eliminated carisoprodol with an overall half-life of 376 min, and only small amounts of meprobamate were recorded. This subject was found to be a poor metabolizer of mephenytoin. In spiked human sera, protein binding of carisoprodol was in the range of 41-67%, whereas meprobamate was bound to a lesser extent, 14-24%.
This is the end of the thread.
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