![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 20 to 44 of 45. Go back in thread:
Posted by Roman on November 2, 2002, at 20:09:25
In reply to Can you get Eskimo 3..., posted by meow mary on November 2, 2002, at 19:59:36
I found it at the local Naturals/Vitamin shop.
Posted by viridis on November 2, 2002, at 20:19:02
In reply to Can you get Eskimo 3..., posted by meow mary on November 2, 2002, at 19:59:36
You can also order it from www.iherb.com -- I've used them many times, and they seem very reliable, plus usually have better prices (sometimes MUCH better) than health food stores.
Posted by meow mary on November 2, 2002, at 22:25:51
In reply to Re: Can you get Eskimo 3... » meow mary, posted by viridis on November 2, 2002, at 20:19:02
Posted by disney4 on November 3, 2002, at 9:17:41
In reply to Re: Fish Oil, all right, all ready, I'll try it..., posted by Ed O`Flaherty on November 2, 2002, at 16:33:45
Hi Ed,
I took an extra 1000mg of my Salmon Oil right before bed, and I know it helped, because I woke up about 2AM with that same feeling I get when I start a new AD, somewhat energized and buzzed, but it was so much milder!!!!!! I think I may stick with the GNC Salmon oil, because it is helping, and I can spread it out during the day. My only concern is the blood glucose level, and the possibility of contamination. I only take 2 though, so I don't think it is affecting my glucose level too much, as I am not a diabetic, so I may stick with it for now. Also the GNC rep told me if I was concerned about the possibility of contaminents in fish oil, than the Salmon is the way to go. I am considering buying the twinlab brand, but I am afraid that would be too high a dose for me at one time. The Eskimo 3 brand is another one I may try, since I like the way they purify the oil, but it seems cost prohibitive for me, when the Salmon Oil is clearly working. I am going to continue to research this.
Posted by Larry Hoover on November 3, 2002, at 12:11:07
In reply to Re: Fish Oil, all right, all ready, I'll try it... » Ed O`Flaherty, posted by disney4 on November 3, 2002, at 9:17:41
> Hi Ed,
>
> My only concern is the blood glucose level, and the possibility of contamination. I only take 2 though, so I don't think it is affecting my glucose level too much, as I am not a diabetic, so I may stick with it for now.There are two different mechanisms by which fish oil might affect glucose regulation. One is an acute effect (immediate) and the other chronic (long-term). Neither one is any concern to someone who is not already insulin-resistant, as both improve the responsiveness of your body to insulin signalling. The DHA in fish oil upregulates the synthesis of insulin receptors in skeletal muscle, acting to prevent insulin resistance and the development of type-2 diabetes, or what is known as Syndrome X. For those already under treatment for glucose regulation problems, adding fish oil to the diet may temporarily affect the dose and timing of medication required, so medical supervision may be necessary. However, that effect diminishes over time.
The issue of contamination may be a red herring, if you'll pardon the horrible play on words. The British government agency MAFF has probably got the premier food-surveillance and analysis program in the world today, and their analyses of commercial fish oils does not show gross contamination, with the exception of some cod liver oils. Liver is where the toxicants accumulate most readily, but you shouldn't use liver oils daily in any case, because they are so full of fat-soluble vitamins. Commercial fish oils are a commodity, just like pork bellies. There probably isn't too much variability between brands, except perhaps those brands which are supposed to have been 'cleaned up', for which you pay a premium. I'm not so sure I'd take their word for it. The British studies don't seem to find much difference (although I may be misinterpreting that issue).
The reason I don't think contamination is too much of an issue arises from my studies of epidemiology. People who eat fish are healthier than those who don't, in a vast number of ways of measuring health. Those fish may or may not have been grossly contaminated, but except for some 'hot spots' of local contamination, there does not seem to be a link between fish consumption and negative outcomes. People are eating the same fish from which the oils originate, and are healthier because of it.
You might want to look at it the choice this way: Is it better to remain in a mental state for which I sought treatment (proven ill health), or take the risk that consuming fish products might make me sick down the line?
>Also the GNC rep told me if I was concerned about the possibility of contaminents in fish oil, than the Salmon is the way to go.Yes, salmon is a good choice, with respect to contaminant levels.
>I am considering buying the twinlab brand, but I am afraid that would be too high a dose for me at one time.
I don't understand the link between brand and dose. You want to take as much fish oil as is necessary to provide about 1 gram/day of EPA.
>The Eskimo 3 brand is another one I may try, since I like the way they purify the oil, but it seems cost prohibitive for me, when the Salmon Oil is clearly working. I am going to continue to research this.
I'm not convinced the extra cost is worth it, but some may decide that controlling as many variables as possible is a contributor to peace of mind.
Posted by disney4 on November 3, 2002, at 19:45:38
In reply to Re: Fish Oil, all right, all ready, I'll try it..., posted by Larry Hoover on November 3, 2002, at 12:11:07
Thanks for all the helpful information! I wanted to clarify what I meant about the TwinLab brand and higher EPA-DHA levels. They make a product called Mega Twin Fish oil, where a 1gm capsule contains 600 mg EPA and 240 mg DHA, where as my GNC Salmon Oil 1 gm capsule contains 180 mg EPA and 120 mg DHA. Although the GNC still costs less in cost comparison, the TwinLab would cut down on oil intake to get the same dosage of active ingrediants, which seems like a plus to me, although I want to up my intake gradually, before I would consider taking that high of a dosage at one sitting. Do you have any sugestions for how high I would want to safely go to help with OCD and bipoalr disorder (at this time I am on the depressed side)? I have read a few reports on myofacial pain at the higher doses.
Thanks again,
Elsie
Posted by Larry Hoover on November 3, 2002, at 22:21:20
In reply to Re: Fish Oil, all right, all ready, I'll try it... » Larry Hoover, posted by disney4 on November 3, 2002, at 19:45:38
> Although the GNC still costs less in cost comparison, the TwinLab would cut down on oil intake to get the same dosage of active ingrediants, which seems like a plus to me, although I want to up my intake gradually, before I would consider taking that high of a dosage at one sitting. Do you have any sugestions for how high I would want to safely go to help with OCD and bipoalr disorder (at this time I am on the depressed side)?
Stoll's preliminary research used 9.6 grams/day of omega-3's from fish oil. That's about 30 of your GNC-type capsules a day. I think that maintaining a daily average intake of 5 or 6 grams of fish oil a day is a good objective. Stoll was trying to prove a point, based on an acute treatment protocol. I think that a maintenance dose need not be so high. You're wise to gradually raise the dose. Some people don't tolerate fish oil well.
>I have read a few reports on myofacial pain at the higher doses.
> Thanks again,
> ElsieI can't find anything anywhere that refers to myofascial pain arising from using fish oil or anything like that. Could you point to a source for this idea? I'd be happy to look into it.
Lar
Posted by disney4 on November 3, 2002, at 22:46:23
In reply to Re: Fish Oil, all right, all ready, I'll try it..., posted by Larry Hoover on November 3, 2002, at 22:21:20
I read about the myofacial pain in two reports on this site, but it seems uncommon to me as well. I think it was caused from starting out at very high doses, which is never wise with anything. What brand of fish oil are you using. I was considering Omegabrite, but I need a high DHA content too, because I am in a depressed state, and need some of DHA's mood elevating properties. I know the recomended amount is a 2:1 ratio of EPA to DHA, but most products seem like a 30:20, with the exception of the Twinlabs, and I suspect they may be using cod liver oil to get the high concentration of EPA and DHA in such a small amount of oil. When I looked up the trademark Seven Seas Healthcare, they were basically a cod liver oil supplier, and cod liver oil is fish oil.
After researching further, I may try a product called Health From the Sun. They specialize in fish oils, and their products have been used in some of the research. They are more concentrated in EPA and DHA. The one I am considering is called Ultra 30/20 Fish Oil™, Health From The Sun, 1000 mg., 90 Capsules
Helps Support Healthy Heart Function & Joint Flexibility
Dietary SupplementHealth From The Sun Ultra-30/20 Fish Oil™ supplies omega-3 EPA (30%-600 mg per serving) and DHA (20%-400 mg per serving) in natural triglyceride form. Molecularly distilled and guaranteed for omega-3 potency, Ultra 30/20 Fish Oil has nine years of clinical studies that show it supports healthy heart function and joint flexibility.
Ultra 30/20 Fish Oil also has five years of clinical safety studies and independent laboratories guarantee oil quality, purity and truth-in-labeling.
Ultra 30/20 Fish Oil is from Health From The Sun, "The Leader in Essential Fatty Acid Nutrition"™
Supplement Facts:
Serving Size 2 Capsules
Servings Per Container 45Amount Per Serving % DV*
Calories 20
Calories from Fat 20
Total Fat 2 g 3%*
Saturated Fat 0 g 0%*
Cholesterol 20 mg 7%*
Vitamin E 4 IU 13%
-----------------------------------------------------------
Omega-3-Fatty Acids 1.2 g +
EPA (600 mg)
DHA (400 mg)
-----------------------------------------------------------
* Percent Daily Values are based on a 2000 calorie diet.
+ Daily Value not establishedIngredients: All natural fish body oil concentrate, gelatin, glycerin and mixed tocopherols.
Directions: One to two capsules twice daily. "
Expiration date: Approx. 2 years after the date of purchase.
Brand: Health From The Sun
1000 mg. each, 90 CapsulesSuggested Retail Price: $29.99
>
>
Posted by Larry Hoover on November 4, 2002, at 8:23:05
In reply to Re: Fish Oil, all right, all ready, I'll try it... » Larry Hoover, posted by disney4 on November 3, 2002, at 22:46:23
> I read about the myofacial pain in two reports on this site, but it seems uncommon to me as well.
Well there's nothing in Medline/Pubmed, and I didn't find anything on Google either.
>What brand of fish oil are you using.
Whatever. I've probably got four or five brands. Country Life or Walmart's Spring Valley seem fine to me.
>I was considering Omegabrite, but I need a high DHA content too, because I am in a depressed state, and need some of DHA's mood elevating properties. I know the recomended amount is a 2:1 ratio of EPA to DHA, but most products seem like a 30:20, with the exception of the Twinlabs, and I suspect they may be using cod liver oil to get the high concentration of EPA and DHA in such a small amount of oil. When I looked up the trademark Seven Seas Healthcare, they were basically a cod liver oil supplier, and cod liver oil is fish oil.
Yes, cod liver oil is fish oil, but it doesn't have an appreciably different ratio of fatty acids than the rest of the fish would have. I can't see anyone using liver oils undeclared on the label (it's more expensive). There are chemical processes to create more concentrated versions of fish oil.
A number of recent studies have used ethyl-eicosapentaenoate with good success. That's just the ethyl alcohol ester of the free fatty acid EPA. Yes, DHA is beneficial in its own right, but there's no a priori reason to believe that you need to take an oil enriched proportionately in DHA. Your body will look after the details.
>
> After researching further, I may try a product called Health From the Sun. They specialize in fish oils, and their products have been used in some of the research.I think the only issue around brand of oil is choosing one that you're going to take. Find your comfort level, but take the oil.
Maybe I'm not the one to ask about toxins and all that stuff. As an environmental toxicologist, I well remember how I felt when I first started to realize just how seriously human activity has contaminated the environment. Everywhere I looked, there was something to concern me. Chemicals leaching from plastic into food. Acid rain mobilizing heavy metals. There was always something new to fear. But guess what? You can't avoid pollution. You can reduce it, with wise choices, but avoid it? Not a chance.
Do you know what the most recent pollutant "discovery" is? Pharmaceutical drugs emitting from sewage treatment plants. All the antidepressants and hormones and heart drugs and so on are going in one side of the STP, and coming right out the other end, because bacteria haven't got the enzymes which fit these molecules to break them down. If your tap water comes from a surface water source (river, lake, reservoir), you can almost be certain you're drinking these drugs. Bottled water? About a 50% chance, as around that proportion of bottled water is nothing more than municipal tap water.
You see where I'm going? A good brand of fish oil is the one in your stomach.
Lar
Posted by disney4 on November 5, 2002, at 10:48:05
In reply to Re: Fish Oil, all right, all ready, I'll try it..., posted by Larry Hoover on November 4, 2002, at 8:23:05
You are right about contaminents. It helps to hear that, because I am so phobic about pollutants, germs, etc...I am dignosed with OCD as well as Bipolar, so that may explain it. I did order the Health from The Sun brand, and I am increasing my dosage gradually. I need the extra mood support!!!!!!
Elsie :)
Posted by McPac on November 5, 2002, at 20:25:45
In reply to Re: Fish Oil, all right, all ready, I'll try it... » Larry Hoover, posted by disney4 on November 5, 2002, at 10:48:05
"You want to take as much fish oil as is necessary to provide about 1 gram/day of EPA."
>>>>>>>>>>>>>>What about DHA? Does it matter if it's 1 gram of EPA alone, EPA & DHA together, etc.? DHA is also good for depression right?
Posted by disney4 on November 5, 2002, at 20:58:28
In reply to Larry Re: Fish Oil, all right, all ready,, posted by McPac on November 5, 2002, at 20:25:45
There has been research on both the EPA and DHA for mood stabilization and AD benefits. My take on it is that the EPA provides more of the mood stabilization and the DHA more of the AD properties. I am going to be taking 900 mg of EPA and 600mg of DHA daily, and move up from there if need be.
Posted by Larry Hoover on November 5, 2002, at 21:04:07
In reply to Larry Re: Fish Oil, all right, all ready,, posted by McPac on November 5, 2002, at 20:25:45
> "You want to take as much fish oil as is necessary to provide about 1 gram/day of EPA."
>
> >>>>>>>>>>>>>>What about DHA? Does it matter if it's 1 gram of EPA alone, EPA & DHA together, etc.? DHA is also good for depression right?If you take a rather typical fish oil, you'll get about 2/3 of a gram of DHA for every gram of EPA. I was basing the EPA dose on the best available study, which showed the maximum antidepressant effect at about 1 gram EPA/day. I consider the effect of the DHA to be a bonus.
Posted by mvn_on on November 7, 2002, at 14:31:27
In reply to Re: Larry Re: Fish Oil, all right, all ready,, posted by Larry Hoover on November 5, 2002, at 21:04:07
You might try taking natural vitamin E 400iu with the fish oil. I also keep them in the fridge as soon as I open the bottle so they don't get nasty smelling. The first day I tried it I felt like a little cloud lifted. It was surprising.
PS I have read that fish oil omega 3 fatty acids will help lose weight gain from ssri's
Posted by disney4 on November 7, 2002, at 14:41:41
In reply to Re: Larry Re: Fish Oil, all right, all ready,, posted by Larry Hoover on November 5, 2002, at 21:04:07
Hi again Larry,
Have you read anything about fish oil keeping better refridgerated? I have always kept mine in a kitchen cabinet, and there is nothing on the bottle that indicates product stays fresher when refridgerated. Just pondering this after reading the latest posting.
Posted by Larry Hoover on November 7, 2002, at 15:03:11
In reply to Re: Larry Re: Fish Oil, all right, all ready, » Larry Hoover, posted by disney4 on November 7, 2002, at 14:41:41
I suppose it can't hurt to refrigerate fish oil capsules, but I don't see why you'd have to. Rancidity is caused by a reaction with oxygen, and the whole point of those gelatin capsules is to keep air out. Another condition promoting rancidity is sunlight, so you shouldn't leave your fish oil on the windowsill. The third condition is temperature, so you want to keep them relatively cool (again, not in sunlight would probably be sufficient). Refrigeration should certainly look after the temperature and sunlight issues, but I don't see it as necessary. So long as there's an added antioxidant (e.g. tocopherol), the capsules should remain palatable long enough for you to finish them off.
[error]
Posted by babs on November 7, 2002, at 17:14:48
In reply to Re: Larry Re: Fish Oil, all right, all ready,, posted by mvn_on on November 7, 2002, at 14:31:27
Where did you read about this? I'd be VERY curious. An appealing thought to say the least.
Posted by Larry Hoover on November 7, 2002, at 20:21:13
In reply to fish oil counters weight gain? » mvn_on, posted by babs on November 7, 2002, at 17:14:48
In direct answer to the subject line, yes it does, but only under certain conditions.
A high carbohydrate low-fat diet causes the liver and cells called adipocytes to create fat from carbohydrates, in a process called de novo lipogenesis. That conversion can be higher than 75%, according to recently published experiments.
The long-chain omega-3 fatty acids in fish oil change a number of things which work together to retard the accumulation of fat in your tissues. These include improving insulin-sensitivity (and thereby lowering insulin response to carb intake), and reducing circulating levels of blood triglycerides. Fish oil changes the way your body uses fat, promoting its use for energy now, rather than storing it for later.
One important extra bit is the necessity to get enough exercise to induce deep aerobic respiration. In other words, break a sweat, at least once a day. There is some evidence that this helps muscle cells in retaining insulin sensitivity, which induces them to burn fat.
EMBO Rep 2001 Apr;2(4):282-6
Mechanisms of nutritional and hormonal regulation of lipogenesis.Kersten S.
Nutrition, Metabolism and Genomics Group, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands. [email protected]
Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids and by fasting. These effects are partly mediated by hormones, which inhibit (growth hormone, leptin) or stimulate (insulin) lipogenesis. Recent research has established that sterol regulatory element binding protein-1 is a critical intermediate in the pro- or anti-lipogenic action of several hormones and nutrients. Another transcription factor implicated in lipogenesis is the peroxisome proliferator activated receptor gamma. Both transcription factors are attractive targets for pharmaceutical intervention of disorders such as hypertriglyceridemia and obesity.
Posted by mvn_on on November 8, 2002, at 9:35:51
In reply to fish oil counters weight gain? » mvn_on, posted by babs on November 7, 2002, at 17:14:48
I read it at the following site. I don't take responsibility for the validity, but I found it interesting too...enough so to at least give it a try.
http://www.prozactruth.com/weight.htm
Posted by inertia on November 16, 2002, at 2:34:44
In reply to Re: more on fish oil, posted by Larry Hoover on October 30, 2002, at 22:28:33
The Archives of General Psychiatry study says that 1mg/day of EPA is more effective than higher doses and, in fact, EPA seems to have little effect at doses of 2mg/day or 4mg/day.
However, Stoll study shows remarkable improvement on 9.6mg/day!
Can anybody explain this? I want to take the most efficacious dose.
Posted by Larry Hoover on November 16, 2002, at 8:35:26
In reply to Re: more on fish oil, posted by inertia on November 16, 2002, at 2:34:44
> The Archives of General Psychiatry study says that 1mg/day of EPA is more effective than higher doses and, in fact, EPA seems to have little effect at doses of 2mg/day or 4mg/day.
Correct, except it was grams/day.
> However, Stoll study shows remarkable improvement on 9.6mg/day!
Grams again.
> Can anybody explain this? I want to take the most efficacious dose.Stoll's study was very brief. Excess omega-3's induce enzymes which convert them to fuel (something which seldom happens otherwise). I'm just guessing, but I'd bet that Stoll's subjects would have plateaued quickly. Alternatively, there may be a fundamental difference in the two subject populations.
You might want to consider a higher dose for a short period (acute supplementation), then dropping back to the 1 gram/day dose for maintenance.
Larry
Posted by Ed O`Flaherty on November 16, 2002, at 10:45:17
In reply to Re: more on fish oil, posted by inertia on November 16, 2002, at 2:34:44
I saw this report a few weeks ago and it is quite puzzling.Stoll used 9.6g because he was dealing with Bipolar and wanted to get enough in to see would it work.However he generally recommends a smaller dose now-rarely over 5g.This latest report is from a small sample for a short period.Longer periods and larger numbers are indicated to give the full answer.
Posted by Kairos on November 17, 2002, at 3:05:59
In reply to more on fish oil, posted by Larry Hoover on October 30, 2002, at 10:33:06
Larry Hoover!
Researchers likeyou are a GOD send! My husband is taking fish oil - at my request as I've done some prelim research myself - BUT - What I need from you is the exact dosage amounts that you've come across in research?My husband is taking "Spring Valley's - Natural Fish Oil Concentrate - with Omega 3 fatty acids" - HOWEVER -
As I scan your articles I can't make heads nor tails of the recommended dosage - it states 3 g/d.
My bottle states take it three times a day - and the EPA is rated at 180 mg, the DHA at 120 mg. There is another listing of "Natural Fish Oil Concentrate at 1000 mg.
How many of these single doses equal 3 g/d?
ANY and I mean ANY articles that refer to fish oil are of extreme importance to me - if you can add to my collection and knowledge I'd surely apprecciate it -
My husband was impressed taht you posted this stuff! I think he feels reallly reallly alone in all this.
Thanks for being YOU!
Kairos
> I am a research addict. I can't help myself. <big grin>
>
> The more I read about the beneficial health effects of long-chain omega-3
> fatty acids, the more convinced I am that every person should be taking
> them. If you have any sort of mental disorder, I cannot emphasize enough,
> take fish oil! There is now evidence that DHA, the longer of the two omega-3
> in fish oil, actually regulates transcription of DNA in the brain. It not
> only acts as a functional component of neuronal membranes, making the
> receptors work better, it also helps control the number of receptors, and
> how sensitive they are (among other things).
>
> People sometimes report that they have problems taking fish oil, due to
> stomach upset. There may be a good scientific reason for that......if you're
> deficient in essential fatty acids, you do not secrete bile sufficient for
> the absorption of fatty acids, and you get stomach upset, gas, and
> possibly, diarrhea. The only solution is to start at a low dose, and
> gradually work up as tolerance builds. (The same holds true for many
> nutrients, by the way. Deficiency of some nutrients is actually caused by
> deficiency of those same nutrients, because of malabsorption.) Another
> reason for stomach upset is poor quality fish oil. If you break a capsule
> open,
> it should not smell strongly 'fishy'. In any case, if stomach upset occurs,
> try
> changing brands. Look for one with tocopherol added (a natural preservative,
> vitamin E).
>
> I've posted links to Medline articles, from which I've extracted some
> quotations. If your browser does not show the whole link as highlighted
> text, make sure you paste in the wrapped portion.
>
> Some of these articles also have links to full-text versions. If so, there
> will be a link right below the title, on the Medline page.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=12002796&dopt=Abstract
>
> "Dietary n-3 FA deficiency influences specific neurotransmitter systems,
> particularly the dopamine systems of the frontal cortex."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=11929197&dopt=Abstract
>
> "Phospholipid supplementation induced a significant increase of b-wave
> amplitude in both control and deficient groups and restored normal fatty
> acid composition in brain regions and retina in deficient mice. DHA-rich
> phospholipids may improve learning ability, visual function and reverse
> biochemical modifications in old mice fed an n-3 polyunsaturated fatty
> acid-deficient diet; they also may improve visual function in old mice fed a
> balanced diet."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=11724460&dopt=Abstract
>
> "Comprehensive clinical studies have shown that dietary supplementation with
> marine oil or single-cell oil sources of LC-PUFA results in increased blood
> levels of DHA and arachidonic acid, as well as an associated improvement in
> visual function in formula-fed infants matching that of human breast-fed
> infants. The effect is mediated not only by the known effects on membrane
> biophysicalproperties, neurotransmitter content, and the corresponding
> electrophysiological correlates but also by a modulating gene expression of
> the developing retina and brain.....DHA also has significant effects on
> photoreceptor membranes and neurotransmitters involved in the signal
> transduction process; rhodopsin activation, rod and cone development,
> neuronal dendritic connectivity, and functional maturation of the central
> nervous system."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=2139096&dopt=Abstract
>
> "The results of serial biopsy samples of the cerebral cortex indicated that
> the changes of brain fatty acid composition began as early as 1 week after
> fish oil feeding and stabilized at 12 weeks. The DHA content of the
> phosphatidylethanolamine of the frontal cortex increased progressively from
> 3.9 +/- 1.2 to 28.4 +/- 1.7 percent of total fatty acids. The n-6 fatty
> acid, 22:5, abnormally high in the cerebral cortex of n-3 deficient monkeys,
> decreased reciprocally from 16.2 +/- 3.1 to 1.6 +/- 0.4%. The half-life (t
> 1/2) of DHA in brain phosphatidylethanolamine was estimated to be 21
> days....The biochemical evidence of n-3 fatty acid deficiency was completely
> corrected."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=11590222&dopt=Abstract
>
> "These results indicate that the altered learning behavior associated with a
> long-term n-3 fatty acid deficiency is reversed by supplementing 22:6n-3
> after weaning, when the levels of competing n-6 fatty acids in the diet and
> brain lipids are limited."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=11880617&dopt=Abstract
>
> "The altered genes included those controlling synaptic plasticity,
> cytosceleton and membrane association, signal transduction, ion channel
> formation, energy metabolism, and regulatory proteins. This effect seems to
> be independent of the chain length of fatty acids, but the n-3 structure
> appears to be important. Because n-3 polyunsaturated fatty acids have been
> shown to play an important role in maintaining normal mental functions and
> docosahexaenoic acid-containing ethanolamine phosphoglyceride (18:0/22:6)
> molecular species accumulated in response to n-3 fatty acid feeding, a
> casual relationship between the two events can be surmised."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=12296294&dopt=Abstract
>
> "Feeding fish oil results in partial replacement of arachidonic acid in
> inflammatory cell membranes by EPA. This change leads to decreased
> production of arachidonic acid-derived mediators. This response alone is a
> potentially beneficial anti-inflammatory effect of n-3 PUFA. However, n-3
> PUFA have a number of other effects which might occur downstream of altered
> eicosanoid production or might be independent of this activity. For example,
> animal and human studies have shown that dietary fish oil results in
> suppressed production of pro-inflammatory cytokines and can decrease
> adhesion molecule expression. These effects occur at the level of altered
> gene expression. This action might come about through antagonism of the
> effects of arachidonic acid-derived mediators or through more direct actions
> on the intracellular signalling pathways which lead to activation of
> transcription factors such as nuclear factor kappa B (NFB). Recent studies
> have shown that n-3 PUFA can down regulate the activity of the nuclear
> transcription factor NFB."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=11725696&dopt=Abstract
>
> "The supplement group received the ingredients in chow inserts at a dosage
> that was equivalent to three times the maximum safe daily dosage for fish
> oil and the usual daily dosage for garlic (the maximum safe daily dosage
> recommended by the United States Food And Drug Administration for a 70-kg
> human is a total of 3 g/day intake of EPA and HDA omega-3 fatty acids from
> conventional and dietary sources....Acutely and chronically, there were no
> differences in external appearance, level of activity, daily food
> consumption, blood cell count, kidney function, thyroid function,
> prothrombin time (PT), and activated partial prothrombin time (PTT), which
> remained within normal ranges in the supplement group. Organ histology
> remained unchanged. Although during the chronic toxicity period the
> triglyceride and LDL suppression persisted, it was noted that total
> cholesterol and HDL levels increased."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=10617969&dopt=Abstract
>
> "In the United States, intake of n-3 fatty acids is approximately 1.6 g/d
> ( approximately 0.7% of energy), of which 1.4 g is alpha-linolenic acid
> (ALA; 18:3) and 0.1-0.2 g is eicosapentaenoic acid (EPA; 20:5) and
> docosahexaenoic acid (DHA; 22:6)....Attaining the proposed recommended
> combined EPA and DHA intake of 0.65 g/d will require an approximately 4-fold
> increase in fish consumption in the United States."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=11844977&dopt=Abstract
>
> "For adults, n-3 long chain polyunsaturated fatty acid supplementation is
> implicated in improving a wide range of clinical pathologies involving
> cardiac, kidney, and neural tissues. Studies generally agree that whole body
> conversion of 18:3n-3 to 22:6n-3 is below 5% in humans, and depends on the
> concentration of n-6 fatty acids and long chain polyunsaturated fatty acids
> in the diet."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=11478378&dopt=Abstract
>
> "...brain slices from Et-DHA-treated fetuses formed less oxidation products,
> as detected by thiobarbituric acid (TBA), compared to controls. Furthermore,
> brain-lipid extracts from Et-DHA but not ethyl-oleate treated fetuses,
> exhibited hydroxyl radical scavenging activity, as demonstrated by electron
> spin-resonance technique. Part of the beneficial effect of Et-DHA
> administration on the fetal brain may be attributed to enhanced free-radical
> scavenging capability, a phenomenon not directly related to vitamin E or
> lipid-soluble antioxidant levels."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=8093816&dopt=Abstract
>
> "In our experiments, feeding animals with oils that have a low
> alpha-linolenic content results in all brain cells and organelles and
> various organs in reduced amounts of 22:6(n-3), compensated by an increase
> in 22:5(n-6). The speed of recuperation from these anomalies is extremely
> slow for brain cells, organelles and microvessels, in contrast with other
> organs. A decrease in alpha-linolenic series acids in the membranes results
> in a 40% reduction in the Na-K-ATPase of nerve terminals and a 20% reduction
> in 5'-nucleotidase. Some other enzymatic activities are not affected,
> although membrane fluidity is altered. A diet low in ALNA induces
> alterations in the electroretinogram which disappear with age: motor
> function and activity are little affected but learning behaviour is markedly
> altered. The presence of ALNA in the diet confers a greater resistance to
> certain neurotoxic agents, i.e. triethyl-lead."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=2564887&dopt=Abstract
>
> "The amounts estimated to prevent deficiencies in the elderly are 800-1100
> mg/d of alpha-linolenic acid and 300-400 mg/d of EPA and DHA combined. "
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=9323581&dopt=Abstract
>
> "The adequate supply of essential fatty acids (EFA) to the body depends upon
> sufficient dietary intake and subsequent efficient intestinal absorption.
> Lipid malabsorption is not only a leading cause of EFA deficiency (EFAD),
> but also occurs secondarily to EFAD....EFAD in itself affects the deficiency
> state by impairment of EFA absorption due to its effects on bile formation
> and on chylomicron secretion."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=11115801&dopt=Abstract
>
> "Data from the Rotterdam Study showed that high intakes of the following
> nutrients were associated with an increased risk of dementia after
> adjustment for confounders: total fat (RR=2.4 (95%CI: 1.1-5.2)), saturated
> fat (RR=1.9 (95%CI: 0.9-4.0)), and cholesterol (RR=1.7 (95%CI: 0.9-3.2)). A
> high fish consumption, an important source of n-3 PUFAs, reduced the risk of
> dementia (RR=0.4 (95%CI: 0.2-0.9)). In the Zutphen Elderly Study a high
> linoleic acid intake was associated with cognitive impairment (OR=1.8
> (95%CI: 1.0-3.0)). A high fish consumption tended to be inversely associated
> with cognitive impairment and decline (RR=0.5, 95%CI: 0.2-1.2)."
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=8192673&dopt=Abstract
>
> "Feeding animals with diets high in saturated fat induces insulin
> resistance, and replacing saturated fat isocalorically with poly-unsaturated
> fat, especially long-chain omega-3 fatty acids, will prevent the development
> of insulin resistance in skeletal-muscle tissue....Insulin binding to intact
> sarcolemmal vesicles prepared from rats fed on diets high in omega-3 fatty
> acids increased 14-fold compared with animals fed on the low-omega-3 diet (P
> < 0.0001)."
>
>
>
>
>
>
>
Posted by linkadge on November 17, 2002, at 7:43:14
In reply to Re: more on fish oil, posted by Kairos on November 17, 2002, at 3:05:59
Omega 3 now, is not just a secluded bunch
in a snake oil cult. Omega 3 really does work.Is it a medication ? In some ways yes and no.
One study showed dramatic reduction in suicidal
behaviour and improvement in mood on 1 g of EPA.
This is 6 of the capsuls you take per day. This is what I have been doing (2 per meal) and am feeling fine. It seems that the dosage doesn't matter as much as the time you're on it.
Higher dosages may bring results faster but
if you can't afford the very high dosage, take
a lower dose, don't say the heck with it and
take none.Take it and keep taking it, thats all I can say.
Linkadge
Go forward in thread:
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
[email protected]
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.