Psycho-Babble Medication Thread 90939

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topamax+lamictal = less stimulant poop out?

Posted by JohnX2 on January 21, 2002, at 0:33:54

I don't get stimulant poop out (at least
from taking pseuedoepedrine nasal decongestants
during this tree pollen crap in Austing),
now that I am taking Topamax with my Lamictal.
Caffeine doesn't crap out either like it was
for me before.

I wonder if the cascaded modulation of AMPA
and NMDA glutamate receptors by Topamax and Lamictal
coupled with the increased GabaA conductance
by Topamax all work together to substantially lower
the stimulants tolerance/sensitization pathway.

This seems quite feasable to me from what I
have read about the addiction pathway.

It's curious that when I added Topamax on Lamictal
I got no typical glutamate side effects like blurry
vision, slurred speech, etc. Any other anti-convulsant
I added to Lamictal had the usual side effects. I wonder
if there is a interesting synergy when one combines
the two meds. Alas, I seem to be one of the 1st
guinea pigs...

-John

Re: topamax+lamictal; + Acamprosate????

Posted by JohnX2 on January 21, 2002, at 15:03:29

In reply to topamax+lamictal = less stimulant poop out?, posted by JohnX2 on January 21, 2002, at 0:33:54

I should add that I take a 5 mg dose of
Zyprexa, and I believe that 5ht-2 antagonism
may also help alleviate a bit some stimulant
poop out.

I was thinking of testing Acamprosate to my
Lamictal + Topamax and dumping Zyprexa.

Acamprosate is a simple carrier molecule for the amino
acid Taurine which has anti-epileptic properites
and is generally produced naturally in the brain.
I believe it is a GabaB agonist and a mild
NMDA antagonist. (correct me if I am wrong)
Acamprosate has been shown to prevent
ethanol (alcohol) tolerance. I think it may
be a good mood stabilizer and help relieve
agitation.

With this wicked trio you would have
your GabaA,GabaB,AMPA,NMDA all covered from
many angles with few side effects hopefully.
I think it could be a real home run for
bipolar. . Just a random thought.

-John

>
> I don't get stimulant poop out (at least
> from taking pseuedoepedrine nasal decongestants
> during this tree pollen crap in Austing),
> now that I am taking Topamax with my Lamictal.
> Caffeine doesn't crap out either like it was
> for me before.
>
> I wonder if the cascaded modulation of AMPA
> and NMDA glutamate receptors by Topamax and Lamictal
> coupled with the increased GabaA conductance
> by Topamax all work together to substantially lower
> the stimulants tolerance/sensitization pathway.
>
> This seems quite feasable to me from what I
> have read about the addiction pathway.
>
> It's curious that when I added Topamax on Lamictal
> I got no typical glutamate side effects like blurry
> vision, slurred speech, etc. Any other anti-convulsant
> I added to Lamictal had the usual side effects. I wonder
> if there is a interesting synergy when one combines
> the two meds. Alas, I seem to be one of the 1st
> guinea pigs...
>
> -John

Re: topamax+lamictal; + Acamprosate????

Posted by JohnX2 on January 21, 2002, at 15:59:04

In reply to Re: topamax+lamictal; + Acamprosate????, posted by JohnX2 on January 21, 2002, at 15:03:29

Hmm, just saw an abstract postulating that
Lamictal boosts brain taurine anways...interesting...

-john

>
> I should add that I take a 5 mg dose of
> Zyprexa, and I believe that 5ht-2 antagonism
> may also help alleviate a bit some stimulant
> poop out.
>
> I was thinking of testing Acamprosate to my
> Lamictal + Topamax and dumping Zyprexa.
>
> Acamprosate is a simple carrier molecule for the amino
> acid Taurine which has anti-epileptic properites
> and is generally produced naturally in the brain.
> I believe it is a GabaB agonist and a mild
> NMDA antagonist. (correct me if I am wrong)
> Acamprosate has been shown to prevent
> ethanol (alcohol) tolerance. I think it may
> be a good mood stabilizer and help relieve
> agitation.
>
> With this wicked trio you would have
> your GabaA,GabaB,AMPA,NMDA all covered from
> many angles with few side effects hopefully.
> I think it could be a real home run for
> bipolar. . Just a random thought.
>
> -John
>
>
> >
> > I don't get stimulant poop out (at least
> > from taking pseuedoepedrine nasal decongestants
> > during this tree pollen crap in Austing),
> > now that I am taking Topamax with my Lamictal.
> > Caffeine doesn't crap out either like it was
> > for me before.
> >
> > I wonder if the cascaded modulation of AMPA
> > and NMDA glutamate receptors by Topamax and Lamictal
> > coupled with the increased GabaA conductance
> > by Topamax all work together to substantially lower
> > the stimulants tolerance/sensitization pathway.
> >
> > This seems quite feasable to me from what I
> > have read about the addiction pathway.
> >
> > It's curious that when I added Topamax on Lamictal
> > I got no typical glutamate side effects like blurry
> > vision, slurred speech, etc. Any other anti-convulsant
> > I added to Lamictal had the usual side effects. I wonder
> > if there is a interesting synergy when one combines
> > the two meds. Alas, I seem to be one of the 1st
> > guinea pigs...
> >
> > -John

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