Psycho-Babble Medication Thread 70131

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Weekend dosages

Posted by Joe Schmoe on July 14, 2001, at 15:46:47

I am taking 300 mg Wellbutrin SR every day. During the week I have been taking 1.5 mg Klonopin a day - 1 mg in the morning and .5 mg in the afternoon. So far I am very happy with how this is working out (10 days) for my social phobia and dysthymia.

I am wondering to what extent I can safely cut back on the Klonopin on the weekend. I know discontinuing a benzo can lower the seizure threshold, and Wellbutrin can as well. But I am thinking that it might help avoid developing a tolerance to Klonopin if I minimize weekend use. Might minimize Klonopin side effects as well (I have heard there can be sexual effects and memory effects.) Is it safe to take no Klonopin on the weekend? Or maybe just skip a day? Or just take .5 mg each weekend day instead of my normal dose?

Also, is there any risk associated with not taking the Klonopin any later than 2 PM in the afternoon? That leaves 18 hours before the next dose, is that dangerous for seizure purposes?

Any input would be appreciated. I have only been on this for about ten days so I am sure I have no dependence yet, though I am told it is inevitable in time. (What does Klonopin dependence feel like anyway? How long between doses before you start to feel uncomfortable?)

Thanks

Re: Weekend dosages

Posted by SalArmy4me on July 15, 2001, at 16:33:18

In reply to Weekend dosages, posted by Joe Schmoe on July 14, 2001, at 15:46:47

I say forget weekend holiday from Klonopin and try adding something like mirtazapine or buspirone to help with the sexual dysfunction:

Sexual Dysfunction Remedies:
Methylphenidate †
- 5-40 mg/d
- For SSRIs or venlafaxine
- Libido, arousal, orgasm

Dextroamphetamine †
- 5-40 mg/d
- Avoid night dosing (insomnia)
- Libido, arousal, orgasm

Pemoline †
- 18.75-75 mg/d
- Check liver function
- Libido, arousal, orgasm

Ginkgo biloba extract †
- 180-240 mg/d, tid, divided doses
- Potential increased clotting time, possible flatulence
- Libido, arousal, orgasm

Bethanechol †
- 10-50 mg prn 1 hour before sex
- Used for anticholinergic side effects (TCAs, paroxetine); produces cholinergic side effects
- Arousal

Neostigmine †
- 200 mg/d, tid divided doses
- Used for anticholinergic side effects (TCAs, paroxetine); produces cholinergic side effects
- Arousal

Estrogen creams or lubricants
- As needed
- For vaginal dryness, atrophy of vaginal tissue
- Arousal

Amantadine
- 100 mg bid
- Caution in patients predisposed to psychosis
- Orgasm

Cyproheptadine
- 4-12 mg qhs
- MAOIs, TCAs, SSRIs, venlafaxine; watch for reemergence of depressive symptoms; sedating
- Orgasm

Buspirone †
- 30-60 mg/d, bid divided doses
-
- Libido, orgasm

Bupropion †
- 75-150 mg/d, qd or bid divided doses
- For SSRIs or venlafaxine, fluoxetine may raise bupropion levels; usual precautionary measures for bupropion
- Libido, arousal, orgasm

Mirtazapine †
- 15-45 mg/d
- For SSRIs, venlafaxine
- Orgasm

Nefazodone †
- Start 50 mg/d, up to 150 mg/d
- SSRIs, venlafaxine
- Orgasm

Granisetron †
- 1 mg prn
- ? Use of other 5-HT3 antagonists
- Orgasm

Sildenafil
- 50-100 mg/d
- Contraindicated with nitrates
- Libido, arousal, orgasm

Yohimbine †
- 5.4 mg tid
- Can be anxiogenic; ? safety with MAOIs
- Libido, arousal, orgasm

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