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Dr. Bob is Robert Hsiung, MD,
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Posted by Ian on August 16, 1998, at 18:07:32
In reply to Re: Reboxetine (Edronax) , posted by paulk on August 7, 1998, at 12:03:25
> I got more information about Endronax (Regboxetine) that may be of interest. I purchased a package through England to try (hoping to find one with out the sexual side effects). It came with a leaflet intended for patents only but included more information than I've seen to date.> Listed side effects:
> Dry mouth, constipation, sweating, and insomnia> ""Some men may have difficulty in having or maintaining an erection." (I found this to be all too true - could not even get started)
> Difficulty passing urine increased heart rate, feeling of pins and needles, orthopedic hypotension.
> Drug interactions:
> Drugs that lower blood pressure
> Other Ads
> Antibotics e.g. erythromycin, and fluvoxamine
> Azole antifungals e.g. fluconazole
> Heart drugs e.g. flecainide
> Cyclosporin
> Ergot derivatives> From my subjective experience I found it to be quite similar to Bupropion but with a worse sexual side effect.
> I also tried reboxetine and had the same problem - I could not so much as begin to get an erection. I also found it very difficult to urinate, and a maximum dose of bethanecol was only partly helpful.
>
Posted by Charyl on August 28, 1998, at 13:57:37
In reply to Re: Reboxetine (Edronax) , posted by Ian on August 16, 1998, at 18:07:32
> Message to Ian. My mother is 80 years old and
severely depressed. She has been on every
anti-depressant available in the U.S., and we were
very excited about the prospect of Reboxetine,
since one of the few drugs that had been able to
help her in the past 35 years was imipramine, however, her doctor says she is now too old to take it. He is aware of Reboxetine and thinks it
may help her, but is unwilling to try to prescribe
it. We also tried to get her in a study in San
Diego for Reboxetine, but again, she is too old.
Do you have any idea how to get a doctor to prescribe Reboxetine, or how to get a package
from England. We have been told that no doctor
here would be willing to do this.
> > I got more information about Endronax (Regboxetine) that may be of interest. I purchased a package through England to try (hoping to find one with out the sexual side effects). It came with a leaflet intended for patents only but included more information than I've seen to date.> > Listed side effects:
> > Dry mouth, constipation, sweating, and insomnia> > ""Some men may have difficulty in having or maintaining an erection." (I found this to be all too true - could not even get started)
> > Difficulty passing urine increased heart rate, feeling of pins and needles, orthopedic hypotension.
> > Drug interactions:
> > Drugs that lower blood pressure
> > Other Ads
> > Antibotics e.g. erythromycin, and fluvoxamine
> > Azole antifungals e.g. fluconazole
> > Heart drugs e.g. flecainide
> > Cyclosporin
> > Ergot derivatives> > From my subjective experience I found it to be quite similar to Bupropion but with a worse sexual side effect.
> > I also tried reboxetine and had the same problem - I could not so much as begin to get an erection. I also found it very difficult to urinate, and a maximum dose of bethanecol was only partly helpful.
> >
Posted by paulk on August 31, 1998, at 10:48:07
In reply to Re: Reboxetine (Edronax) , posted by Charyl on August 28, 1998, at 13:57:37
> > Message to Ian. My mother is 80 years old and
> severely depressed. She has been on every
> anti-depressant available in the U.S., and we were
> very excited about the prospect of Reboxetine,
> since one of the few drugs that had been able to
> help her in the past 35 years was imipramine, however, her doctor says she is now too old to take it. He is aware of Reboxetine and thinks it
> may help her, but is unwilling to try to prescribe
> it. We also tried to get her in a study in San
> Diego for Reboxetine, but again, she is too old.
> Do you have any idea how to get a doctor to prescribe Reboxetine, or how to get a package
> from England. We have been told that no doctor
> here would be willing to do this.I wouldn't recommend doing this on your own - your mother may have some condition that is keeping the doctor from prescribing imipramine. There are doctors here who will work with you to try an overseas drug - but I would first suggest trying some of the newer ones available here - perhaps effexor - it has been effective for some resistant depressions.
Perhaps a second opinion about the medication - is the doctor an internal medicine guy? - they seem to be better at working whith drug side effects than Pdocs in my opinion.
Why won't he give her imipramine? is her liver or kidneys compromised? problems with urine retention?
What condition is her heart in? Reboxitine can speed up the heart.
I hope you don't try to do this 'on your own'. You can find doctors that understand that taking some risk to improve the quality of life is worth it. You might have to look around a bit; so many of our doctors are worried about getting sued instead of providing the best medicine. Look the doctor in they eyes and ask him what he would do if it was his mother.
Posted by Salvatore Condorelli on October 2, 1998, at 7:34:37
In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03
> For treating dysthmic disorder Effexor has worked much better than other SSRI have. Works well except for the sexual side effects. I am planning to try Reboxetine (Edronax) any information on this norepinephrine re-uptake inhibitor would be appreciated. I am hoping to get a good response minus the side effect.
Posted by Toby on October 14, 1998, at 10:21:35
In reply to Re: Reboxetine (Edronax) , posted by Salvatore Condorelli on October 2, 1998, at 7:34:37
Just read a review of the clinical studies done on Reboxetine. No mention of urinary retention or sexual side effects. The most common side effects listed were increased sweating, blurred vision, insomnia, headache and dry mouth. The most effective doses were between 8 and 10 mg per day and this range had the fewest side effects. About 75% of patients had a greater than 50% decrease in depressive symptoms and many patients began to improve after only 10 days (much faster than most SSRI's). The longest trial reported on was 12 months and patients that responded to Reboxetine continued to respond over the entire 12 months.
Posted by paulk on October 14, 1998, at 20:54:55
In reply to Re: Reboxetine (Edronax) , posted by Toby on October 14, 1998, at 10:21:35
Even the package insert talks about the failure to get an erection. The Great Britain product insert (not at all like a US monograph) is quite up-front about this side effect.
It is much worse than delayed orgasm - there is just no hope of getting started.
Posted by Susan on October 18, 1998, at 23:13:36
In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03
> For treating dysthmic disorder Effexor has worked much better than other SSRI have. Works well except for the sexual side effects. I am planning to try Reboxetine (Edronax) any information on this norepinephrine re-uptake inhibitor would be appreciated. I am hoping to get a good response minus the side effect.Here's some info I found at http://www.neuropharmacology.com.
I'm not clear, is Roboxetine available in the United States? Are there other drugs within the NARI category that might be more effective for those with melancholic symptoms? This is certainly an option I'd like to talk to my doctor about if it's available.
REBOXETINE; ADRAFINIL; MODAFINIL
Reboxetine (Edronax) is an interesting and highly selective
"noradrenergic" agent. Crudely, whereas serotonin plays a vital role in mood,
noradrenaline is essential to maintaining drive and the capacity for reward. There's
a fair bit of evidence that chronically depressive people have dysfunctional and
atypical noradrenergic systems - particularly their alpha 2- and
beta-adrenoceptors. The vastly ramifying central noradrenaline system regulates
alertness and the sleep-wakefulness cycle. It's involved in autobiographical
memory, learning and attention; degree of mental focus; cerebral plasticity and
neuro-protection; and, obscurely but not least, our sensitivity to rewarding
experience and tendency to melancholia or elation. Reboxetine itself doesn't have
disruptive effects on cognitive function and psychomotor performance. These are
annoyingly typical of many traditional clinical mood-brighteners. Indeed the new
NorAdrenaline Reuptake Inhibitors (NARIs) are probably massively under-used
and under-hyped. NARIs and dopaminergics may be especially good for
drive-deficient "anergic" states where the capacity for sustained motivation is
lacking; and for melancholic depressives with a poor ability to cope with stress.
Perhaps surprisingly, preliminary studies suggest reboxetine can actually reverse
tranylcypromine-induced hypertensive crises. The "cheese effect" is usually
triggered by ingesting tyramine-rich foods. Thus NARIs plus MAOIs may prove a
potent form of combination-therapy, at least for those who don't mind their
cocktails well-mixed.
Posted by Melanie on January 12, 1999, at 20:51:25
In reply to Re: Reboxetine (Edronax) , posted by Susan on October 18, 1998, at 23:13:36
Were any of you able to get your hands on a Reboxetine package insert? Would you fax it to me???
Posted by steve on January 14, 1999, at 11:41:47
In reply to Re: Reboxetine (Edronax) , posted by Ian on August 16, 1998, at 18:07:32
someone mentioned bethanecol. What's this?
Posted by steve on January 14, 1999, at 11:44:50
In reply to Re: Reboxetine (Edronax) , posted by Toby on October 14, 1998, at 10:21:35
Could Reboxetine be combined with an SSRI?
Posted by emily on January 17, 1999, at 19:34:37
In reply to Re: Reboxetine (Edronax) , posted by Melanie on January 12, 1999, at 20:51:25
> Does anyone have any information about the sexual side effects of reboxetine in women? Any word on weight gain? I have just started it - some nausea with the first dose, none with the next two. No obvious effects or side effects yet. Thanks for any info.
Posted by Nick on March 7, 1999, at 16:35:08
In reply to Re: Reboxetine (Edronax) , posted by Toby on October 14, 1998, at 10:21:35
> I've been prescribing reboxetine for a few months in the UK. It seems to work; insomnia is the main side effect reported to me; have also seen erectile failure (usually at >8mg/day) and urinary hesitancy in men (case report in the BJPsych about this: doxazosin effective treatment) Wt gain not a problem clinically or in trials published so far. Not licensed for use in elderly.
Posted by Teri on March 14, 1999, at 2:04:51
In reply to Re: Reboxetine (Edronax) , posted by Charyl on August 28, 1998, at 13:57:37
> > Message to Ian. My mother is 80 years old and
> severely depressed. She has been on every
> anti-depressant available in the U.S., and we were
> very excited about the prospect of Reboxetine,
> since one of the few drugs that had been able to
> help her in the past 35 years was imipramine, however, her doctor says she is now too old to take it. He is aware of Reboxetine and thinks it
> may help her, but is unwilling to try to prescribe
> it. We also tried to get her in a study in San
> Diego for Reboxetine, but again, she is too old.
> Do you have any idea how to get a doctor to prescribe Reboxetine, or how to get a package
> from England. We have been told that no doctor
> here would be willing to do this.
> > > I got more information about Endronax (Regboxetine) that may be of interest. I purchased a package through England to try (hoping to find one with out the sexual side effects). It came with a leaflet intended for patents only but included more information than I've seen to date.> > > Listed side effects:
> > > Dry mouth, constipation, sweating, and insomnia> > > ""Some men may have difficulty in having or maintaining an erection." (I found this to be all too true - could not even get started)
> > > Difficulty passing urine increased heart rate, feeling of pins and needles, orthopedic hypotension.
> > > Drug interactions:
> > > Drugs that lower blood pressure
> > > Other Ads
> > > Antibotics e.g. erythromycin, and fluvoxamine
> > > Azole antifungals e.g. fluconazole
> > > Heart drugs e.g. flecainide
> > > Cyclosporin
> > > Ergot derivatives> > > From my subjective experience I found it to be quite similar to Bupropion but with a worse sexual side effect.
> > > I also tried reboxetine and had the same problem - I could not so much as begin to get an erection. I also found it very difficult to urinate, and a maximum dose of bethanecol was only partly helpful.
> > >
I've been on Wellbutrin, aderall, etc, both for depression and ADD, on and off (when they stop working) for years, I would really apreciate any information on how to get Reboxetin in the U.S., throught studies or prescribed.
Thank you
Posted by Dina on March 16, 1999, at 2:57:30
In reply to Re: Reboxetine (Edronax) , posted by Teri on March 14, 1999, at 2:04:51
I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
Thanks,
-dina.
[email protected]
Posted by dina on March 16, 1999, at 3:02:12
In reply to Re: Reboxetine (Edronax) / bethanecol , posted by steve on January 14, 1999, at 11:41:47
> someone mentioned bethanecol. What's this?
It's used to help with urinary retention and some sexual side effects.
It helped me a teeny tiny itsy bitsy bit with urinary retent. & inorgasmia (I think that's the proper term...) but you have to take it like all the time.
Although, I hear it works pretty well for some folks. Plus, the situation is different for men & women.
For sexual side effects, I've heard that some herbal remedies work quite well-- Yohimbe, especially. Also Ginko bilobo.
-dina.
Posted by Elizabeth on March 17, 1999, at 17:20:26
In reply to Re: Reboxetine (Edronax) / bethanecol , posted by dina on March 16, 1999, at 3:02:12
Bethanechol is a muscarinic cholinergic agonist - so it acts in opposition to certain drug effects, namely the *anti*cholinergic ones. The prototypical anticholinergic drugs are atropine and scopolamine, which can be found in deadly nightshade (Belladonna).
The major anticholinergic symptoms are dry mouth, constipation, blurred vision, urinary retention, cognitive impairment, and rapid heartbeat.
Antipsychotics, tricyclic antidepressants, some antihistamines (Benadryl, Atarax), and some of the drugs used to treat Parkinsonism (Cogentin, Artane) are some classes of drugs that have prominent anticholinergic effects.
-elizabeth
Posted by ZZbottom on March 29, 1999, at 17:17:39
In reply to Re: Reboxetine (Edronax) , posted by Nick on March 7, 1999, at 16:35:08
How can I get Reboxetine in U.S.?
Posted by Jeff on April 15, 1999, at 3:15:04
In reply to Re: Reboxetine (Edronax) , posted by Dina on March 16, 1999, at 2:57:30
> I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
>
> Thanks,
> -dina.
> [email protected]I was eager to try Reboxetine and ordered it online from a Swiss pharmacy in Zurich, Victoria Apotheke (www.access.ch/victoria_pharmacy) I am a
very treatment-resistant BP2. I found the Reboxetine showed signs of working within 24-hours - but I am a quick responder. But it had positive
effect after several days. I don't recall any major side-effects. I felt activated and motivated and had much more energy. I still had negative
feelings and thoughts, so we added Prozac in conjunction after two weeks. The Prozac caused an
immediate reversal of all the postive effects - within 24 hours. Prozac was stopped and - within 12 hours - the postive effects of the Reboxetine returned. After 5 weeks, the effects of the Reboxetine 'faded" away and could not be restarted
even with increases in dosage. (This is my normal
pattern with medications and may not apply to others.)
Posted by Reg on April 15, 1999, at 7:50:22
In reply to Re: Reboxetine (Edronax) , posted by Dina on March 16, 1999, at 2:57:30
> I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
>
> Thanks,
> -dina.
> [email protected]I took Reboxetine for one day and felt severe anxiety, numbness (couldn't feel my legs), disorientation and slurring of speech. Heartbeat increased and I will never take this again
Posted by CC on April 20, 1999, at 8:46:32
In reply to Re: Reboxetine (Edronax) , posted by Jeff on April 15, 1999, at 3:15:04
> > I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
> >
> > Thanks,
> > -dina.
> > [email protected]
>
> I was eager to try Reboxetine and ordered it online from a Swiss pharmacy in Zurich, Victoria Apotheke (www.access.ch/victoria_pharmacy) I am a
> very treatment-resistant BP2. I found the Reboxetine showed signs of working within 24-hours - but I am a quick responder. But it had positive
> effect after several days. I don't recall any major side-effects. I felt activated and motivated and had much more energy. I still had negative
> feelings and thoughts, so we added Prozac in conjunction after two weeks. The Prozac caused an
> immediate reversal of all the postive effects - within 24 hours. Prozac was stopped and - within 12 hours - the postive effects of the Reboxetine returned. After 5 weeks, the effects of the Reboxetine 'faded" away and could not be restarted
> even with increases in dosage. (This is my normal
> pattern with medications and may not apply to others.)
>Has anyone heard of reboxetine used in combination with
other medicines, specifically Zoloft and nortriptyline?Are there dosage guidelines for such combinations?
Posted by Nancy on April 21, 1999, at 9:58:00
In reply to Re: Reboxetine (Edronax) , posted by Jeff on April 15, 1999, at 3:15:04
> > I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
> >
> > Thanks,
> > -dina.
> > [email protected]
>
> I was eager to try Reboxetine and ordered it online from a Swiss pharmacy in Zurich, Victoria Apotheke (www.access.ch/victoria_pharmacy) I am a
> very treatment-resistant BP2. I found the Reboxetine showed signs of working within 24-hours - but I am a quick responder. But it had positive
> effect after several days. I don't recall any major side-effects. I felt activated and motivated and had much more energy. I still had negative
> feelings and thoughts, so we added Prozac in conjunction after two weeks. The Prozac caused an
> immediate reversal of all the postive effects - within 24 hours. Prozac was stopped and - within 12 hours - the postive effects of the Reboxetine returned. After 5 weeks, the effects of the Reboxetine 'faded" away and could not be restarted
> even with increases in dosage. (This is my normal
> pattern with medications and may not apply to others.)
>I'm severe bipolar-1, ultra-rapid cycling, anguished mixed states, treatment resistive, and chronically suicidal. No medication would work with my physiology until a brilliant pdoc insisted that my T3 and T4 thyroid levels MUST BOTH BE IN THE UPPER QUARTILE OF THE NORMAL RANGE. Once this was achieved, medication did what it was supposed to do. I was fortunate that the first AD (300mg Effexor XR) worked. Before upper quartile thyroid augmentation, I was treatment resistive in every trial on every US available AD (including 300mg Effexor XR).
I'm wondering if others with similar experience will compare their preferences for either Edronax or Effexor.
Posted by Bren on April 25, 1999, at 18:23:04
In reply to Re: Reboxetine (Edronax) , posted by ZZbottom on March 29, 1999, at 17:17:39
I've been on Edronax for 9 months.Vision is affected e.g. dry eyes and double vision.Since starting the maximum dose - noticed hair loss.
Posted by Eric on May 4, 1999, at 18:09:35
In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03
> I have been taking Reboxetine for 1 month for
chronic fatigue syndrome. I have suffered from CFS
for over 5 yrs after a sudden onset. I have tried
numerous SSRIs & MOI with little positive effect but
Reboxetine has given me a substantial energy boost.Anyone out there have knowledge of Reboxetine/CFS?
Posted by GARY on May 6, 1999, at 19:38:30
In reply to Re: Reboxetine (Edronax) , posted by Eric on May 4, 1999, at 18:09:35
WHERE IS EDRONAX AVAILABLE? WHO MAKES IT?
Posted by Nick on May 9, 1999, at 12:48:47
In reply to Re: Reboxetine (Edronax) , posted by GARY on May 6, 1999, at 19:38:30
> WHERE IS EDRONAX AVAILABLE? WHO MAKES IT?
Its certainly available in the UK - its made by Pharmacia & Upjohn
Nick
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Dr. Bob is Robert Hsiung, MD,
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