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Dr. Bob is Robert Hsiung, MD,
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Posted by qbsbrown on August 3, 2009, at 21:13:15
In reply to Re: Question about an AD scott, posted by SLS on August 3, 2009, at 18:27:47
I've read that magnesium is one of the only minerals/vitamins/supplements that might provide some relief, especially muscular.
I was in great shape when i begun this. Now total muscle wastage, muscle spasms, pretty bad stuff.
Does/will magnesium interfere/compete for any of the neurotransmitters?
Regards,
Brian
Posted by qbsbrown on August 3, 2009, at 22:52:41
In reply to Magnesium Scott?, posted by qbsbrown on August 3, 2009, at 21:13:15
I was wondering about Neurontin for anxiety and insomnia during benzo wd.
Now lyrica was the 2nd most difficult drug to come off of after benzos, but i don't remember a problem w/ neurontin
Of course we'll go one step at a time w/ the tegretol, and i don't know if you can mix those 2 anticonvulsants at the same time, or is a good idea anyway.
It does scare me that neurontin gave me suicidal ideation out of no where a couple of times, for no reason. But other than that, it was more like being social and high.
But i don't know how the whole gaba part interacts w/during the benzo wd.
Regards,
Brian
Posted by SLS on August 4, 2009, at 6:35:32
In reply to Magnesium Scott?, posted by qbsbrown on August 3, 2009, at 21:13:15
> Does/will magnesium interfere/compete for any of the neurotransmitters?
The reason I have suggested magnesium to a couple of people is that it *theoretically* would compete with glutamate for binding to the NMDA receptor, the result of which might be to tone down neuronal excitability. Many people feel calmer with magnesium and sometimes use it as a sleep aid. You don't want to take too much, though. It can act as a laxative.
- Scott
Posted by SLS on August 4, 2009, at 6:37:22
In reply to Neurontin?, posted by qbsbrown on August 3, 2009, at 22:52:41
You can take Neurontin with Tegretol, but I wouldn't recommend adding it at this juncture. It can be somewhat unpredictable.
- Scott
Posted by qbsbrown on August 4, 2009, at 9:04:02
In reply to Re: Neurontin?, posted by SLS on August 4, 2009, at 6:37:22
Well a few wd symptoms that I was absolutely thrilled that it began to alleviate was; extreme sound and noise sensitivity. I would have to sleep w/ ear plugs and eye masks, and STIll, the smallest shade of light coming in the window would wake me up.
That is now back the past 2-3 days. Are you guessing that is because i went up to fast and aggrivated my wd symptoms, and the original ones came back, and/or that it's now metabolizing itself quicker, and that i need to raise the dose?
There are a couple other things that have come back as well.
I don't want to go too quick and too fast, as we saw where that landed me last time.
Stick to the original plan of Fri?
Regards,
Brian
Posted by qbsbrown on August 4, 2009, at 9:07:13
In reply to Re: Magnesium Scott?, posted by SLS on August 4, 2009, at 6:35:32
Can you recommend how much magnesium to take? MGS, and times per day?
Posted by qbsbrown on August 4, 2009, at 9:16:17
In reply to Re: Magnesium Scott?, posted by qbsbrown on August 4, 2009, at 9:07:13
Someone on the alternative board said that the magnesium can be stimulating. That kinda scares me. Don't know how my body will react to it at this juncture.
Is it worth the risk for sleep, calm, and muscle spasms?
Brian
Posted by qbsbrown on August 4, 2009, at 9:26:54
In reply to Tegretol, posted by qbsbrown on August 4, 2009, at 9:04:02
Perhaps a 4 day flare up is expected after my 600mg night experience huh
Posted by SLS on August 4, 2009, at 11:58:06
In reply to Re: Tegretol, posted by qbsbrown on August 4, 2009, at 9:26:54
> Perhaps a 4 day flare up is expected after my 600mg night experience huh
It is hard to say.
Friday is just a few days away.
You'll make it.
- Scott
Posted by qbsbrown on August 4, 2009, at 13:06:32
In reply to Re: Tegretol, posted by SLS on August 4, 2009, at 11:58:06
Yeah, the WD symptoms are real bad right now. I think that starting the gym yesterday and today, plus huge dietary changes, are flaring up symptoms as well, but i think greatly beneficial for me in the long run. I won't raise my dose until these bad symptoms settle a bit.
God Scott, i hope this works.
Brian
Posted by qbsbrown on August 4, 2009, at 13:30:08
In reply to Re: Tegretol, posted by qbsbrown on August 4, 2009, at 13:06:32
When/if I can tolerate 600mgs, do I need to get some blood tests done Scott?
Regards,
Brian
Posted by SLS on August 4, 2009, at 14:55:48
In reply to Blood tests, posted by qbsbrown on August 4, 2009, at 13:30:08
> When/if I can tolerate 600mgs, do I need to get some blood tests done Scott?
I don't recall how often you are supposed to be tested. I would work with your doctor on this. The risk of developing a problem are remote, but still should be checked for regularly.
- Scott
Posted by qbsbrown on August 4, 2009, at 16:06:47
In reply to Re: Blood tests, posted by SLS on August 4, 2009, at 14:55:48
Well, still bad depression this morning. Bad wd symptoms in general. Went for a walk and things were really dysphoric and depressing looking/seeming, almost felt like a nervous breakdown. I for sure don't want to raise until that is gone (I even wonder if 300 is better), if it even does go away. And if it does, I wonder if 100mg increments are better suited for me given my sensitivity. I'll try to hold and see how it is over the next few days. I really hope that it goes away, and that I can continue forward. But I even had these things on 900mgs of Trileptal, which would probably be the same as 600 Tegretol, correct?
Regards,Brian
Posted by qbsbrown on August 4, 2009, at 16:09:47
In reply to Re: Blood tests, posted by qbsbrown on August 4, 2009, at 16:06:47
And although the starting dose of trileptal is 300mgs 2 times a day, i did well on 150mgs 2 times a day 3 years ago for my taper.
I hope my dose isn't too much right now.
Regards,
Brian
Posted by SLS on August 4, 2009, at 17:24:34
In reply to Re: Blood tests, posted by qbsbrown on August 4, 2009, at 16:09:47
I can't be sure, but you might be experiencing an instability of your primary depressive disorder. I encourage you to go up to 600mg. The sooner you can establish some stability, the sooner you can taper the diazepam and add an antidepressant.
- Scott
Posted by qbsbrown on August 4, 2009, at 17:45:24
In reply to Re: Blood tests, posted by SLS on August 4, 2009, at 17:24:34
> I can't be sure, but you might be experiencing an instability of your primary depressive disorder. I encourage you to go up to 600mg. The sooner you can establish some stability, the sooner you can taper the diazepam and add an antidepressant.
>
>
> - ScottI hear ya, but it was the messing around with doses and going too high too fast that revved up my symptoms, and induce the dysphoria and the depressive symptoms and feelings, as all if not most anticonvulsants do induce for me.
We saw what 500mgs of depakote did, which is the normal starting dose. 400mgs of tegretol is the normal starting dose, so why would we not expect the same thing? Maybe because i experienced a better mood after the first couple 100mg doses?
Are you saying get up to 600, then taper, then add an ad? I have horrible reactions to all ADs, so that's kinda sketchy.
Usually, if there was high enough anticonvulsant dosage, the lexapro might help take away the dysphoria/depression, but also induced many bad things in return.
Regards,
Brian
Posted by qbsbrown on August 4, 2009, at 17:54:07
In reply to Re: Blood tests, posted by qbsbrown on August 4, 2009, at 17:45:24
I never had any of these depressive feelings til messing around w/ the anticonvulsants. And i can tell if my symptoms are revved up if my typing becomes more difficult, and many many other symptoms that my wd is revved up which happened since going from 300-600 in one night.
Are you saying to get to 600 for a certain amount of time, then add an AD? Or 600, then taper, then an AD?
They all induce depression minus lexapro, which i mentioned can trigger mania, mixed moods, and even depression/dysphoria, maybe even suicidal ideation itself.
The goal is to be off of all meds. And what ever the best, quickets, safest route I'm all for.
Yes, usually the lexapro would take away the depression/dysphoria that i experience w/ anticonvulsants.
So it's a tough situation.
Regards,
Brian
Posted by qbsbrown on August 4, 2009, at 17:56:46
In reply to Re: Blood tests, posted by qbsbrown on August 4, 2009, at 17:54:07
Maybe if I'm able to get up to 600mgs, I just don't go outside to experience the bad dysphoria and depression, and work on my taper. If it's diazepam alone, i can't make it outside anyway.
Posted by qbsbrown on August 4, 2009, at 18:12:59
In reply to Re: Blood tests, posted by qbsbrown on August 4, 2009, at 17:56:46
I think it's really a bad case of GABA and the CNS really being jacked up. Even taking Niacinimide to help wean off, made me more depressed. So of course a serious psychotropic drug like tegretol would do the same.
Posted by qbsbrown on August 4, 2009, at 23:30:49
In reply to Re: Blood tests, posted by qbsbrown on August 4, 2009, at 18:12:59
Scott, seeing that Tegretol is reacting like every anticonvulsant to me, and causing major depression and dysphoria (but only when I am outside in public), I have 2 options.
To continue w/ the tegretol, and see if it helps/eases the wd (which it initially was), and leave the house as little as possible, so that i don't have to see and expose myself to seeing so many ugly things. I could not leave the apt before it.
Or I can do a phenobarbitol detox. I don't know how the success is on that one.
What do you think?
Regards,
Brian
Posted by SLS on August 5, 2009, at 7:12:14
In reply to Re: Blood tests, posted by qbsbrown on August 4, 2009, at 23:30:49
I'm sorry that things are so complicated for you. I don't think adding Lexapro at this point is ideal if the depression that is now occurring is due to some effect of the Tegretol. Phenobarbital is something for you to move onto if it has an established utility in BZD withdrawal. I don't know enough about it to help you make any decisions. I am thinking that Tegretol might still be useful. The only way to find out is to try. Perhaps you would do better at a higher dosage. If things get significantly worse, then it will be up to you what to do next. Is it possible that very low dosages are ideal for you? You would have to taper the Tegretol to prevent seizures, so you'll get a chance to find out.
It's too bad you can't go right up to 800mg of Tegretol to see how you would react to it. I think at this point, you might not find the stability at 400mg that was hoped for. I don't know what is best for you because I don't have a crystal ball. If it were me, I would want an answer as soon as possible. I would go right up to 600mg at this point and evaluate how you feel on it. If things get worse, then it is time to make a change.
I would just bring up that Topamax (topiramate) seems to be of utility in benzodiazepine and alcohol withdrawal. Still, it sounds like the you would like phenobarbital to be your next drug trial. Interestingly, Topamax works directly on glutamate receptors, something the other anticonvulsants you have tried fail to do. The others have in common the blocking of sodium channels. Maybe that's not what you need.
Overall, I think the phenobarbital is a good choice as long as you respect the drug and its potential to produce respiratory depression if you decide to play with dosages.
- Scott
Posted by qbsbrown on August 5, 2009, at 11:53:53
In reply to Re: Blood tests, posted by SLS on August 5, 2009, at 7:12:14
> I'm sorry that things are so complicated for you. I don't think adding Lexapro at this point is ideal if the depression that is now occurring is due to some effect of the Tegretol. Phenobarbital is something for you to move onto if it has an established utility in BZD withdrawal. I don't know enough about it to help you make any decisions. I am thinking that Tegretol might still be useful. The only way to find out is to try. Perhaps you would do better at a higher dosage. If things get significantly worse, then it will be up to you what to do next. Is it possible that very low dosages are ideal for you? You would have to taper the Tegretol to prevent seizures, so you'll get a chance to find out.
>
> It's too bad you can't go right up to 800mg of Tegretol to see how you would react to it. I think at this point, you might not find the stability at 400mg that was hoped for. I don't know what is best for you because I don't have a crystal ball. If it were me, I would want an answer as soon as possible. I would go right up to 600mg at this point and evaluate how you feel on it. If things get worse, then it is time to make a change.
>
> I would just bring up that Topamax (topiramate) seems to be of utility in benzodiazepine and alcohol withdrawal. Still, it sounds like the you would like phenobarbital to be your next drug trial. Interestingly, Topamax works directly on glutamate receptors, something the other anticonvulsants you have tried fail to do. The others have in common the blocking of sodium channels. Maybe that's not what you need.
>
> http://www.ncbi.nlm.nih.gov/pubmed/17071548?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
> http://www.ncbi.nlm.nih.gov/pubmed/15510234?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
> http://www.ncbi.nlm.nih.gov/pubmed/12858324?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
>
> Overall, I think the phenobarbital is a good choice as long as you respect the drug and its potential to produce respiratory depression if you decide to play with dosages.
>
>
> - Scott
>
>
>
>
>
>
Yes, Lexapro a really bad idea.
I hope and I pray that Tegretol has some value for me. Seeing that my WD effects are raised by what i've done so far, I wonder if there is any way that 600mgs can put out the flames. Now, it's been 6 days of 400 or more, but granted 1 day was 600, 1 day was 500, 2 days were ER version of 400, now 2 days of the 400mgs of regular generic.Do you think that I could raise today? I have a stressful event that I have to go to on Friday, that I'm in no shape to attend right now, and my friend is leaving for the weekend.
Is it too early to try?
My symptoms are revved up. The typing is difficult, the anxiety worse (depression i don't feel, just feels like I'm losing it). When I first started it, it took away my extreme light/sound sensitivity, that i had to wear eye masks and ear plugs for. It got rid of that. It's been back the past 3 nights, and was awake at 3am last night.
I don't know if this is my brain/body adjusting to the medication, or if it's a sign to move up.
I appreciate your thoughts.
Regards,
Brian
Posted by qbsbrown on August 5, 2009, at 12:00:50
In reply to Re: Blood tests, posted by qbsbrown on August 5, 2009, at 11:53:53
But that's a good question. If my symptoms are so revved up and jacked up from 400mgs, perhaps a lower dose is more beneficial. It's tough to tell. I wonder if raising at this point would only increase my wd symptoms, of if it'd help put out the flames? Not sure. What is your theory?
Brian
Posted by qbsbrown on August 5, 2009, at 12:15:27
In reply to Re: Blood tests, posted by SLS on August 5, 2009, at 7:12:14
> I'm sorry that things are so complicated for you. I don't think adding Lexapro at this point is ideal if the depression that is now occurring is due to some effect of the Tegretol. Phenobarbital is something for you to move onto if it has an established utility in BZD withdrawal. I don't know enough about it to help you make any decisions. I am thinking that Tegretol might still be useful. The only way to find out is to try. Perhaps you would do better at a higher dosage. If things get significantly worse, then it will be up to you what to do next. Is it possible that very low dosages are ideal for you? You would have to taper the Tegretol to prevent seizures, so you'll get a chance to find out.
>
> It's too bad you can't go right up to 800mg of Tegretol to see how you would react to it. I think at this point, you might not find the stability at 400mg that was hoped for. I don't know what is best for you because I don't have a crystal ball. If it were me, I would want an answer as soon as possible. I would go right up to 600mg at this point and evaluate how you feel on it. If things get worse, then it is time to make a change.
>
> I would just bring up that Topamax (topiramate) seems to be of utility in benzodiazepine and alcohol withdrawal. Still, it sounds like the you would like phenobarbital to be your next drug trial. Interestingly, Topamax works directly on glutamate receptors, something the other anticonvulsants you have tried fail to do. The others have in common the blocking of sodium channels. Maybe that's not what you need.
>
> http://www.ncbi.nlm.nih.gov/pubmed/17071548?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
> http://www.ncbi.nlm.nih.gov/pubmed/15510234?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
> http://www.ncbi.nlm.nih.gov/pubmed/12858324?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
>
> Overall, I think the phenobarbital is a good choice as long as you respect the drug and its potential to produce respiratory depression if you decide to play with dosages.
>
>
> - Scott
>
>
>
>
>
>Topamax never gave me depression or dyshporia like the others. Just bad derealization, which I hate.
Brian
Posted by SLS on August 5, 2009, at 13:57:53
In reply to Re: Blood tests, posted by qbsbrown on August 5, 2009, at 12:15:27
I'm not working on theory at this point. I think you need to act on empirical observation and make decisions based upon what is known about the drug and how you react to it. I would raise the dosage to 600mg beginning tonight by taking 200mg as your evening dose. Let's see what happens. If you feel a little better tomorrow, maybe you can begin to taper the diazepam after your speaking engagement.
- Scott
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