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Dr. Bob is Robert Hsiung, MD,
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Posted by ed_uk on September 5, 2006, at 15:09:30
In reply to Re: Lyrica (pregabalin) - Side Effects ? » Anhedonic, posted by SLS on September 4, 2006, at 19:57:07
Hi Scott
Keep us up to date with the Lyrica trial. Hope the cognitive side effects wear off.
Ed
Posted by MARTY on September 5, 2006, at 15:32:29
In reply to Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 1, 2006, at 7:29:58
To Scott:
Do you intend to keep trying Lyrica until high dose whatever what ? Because that's what I would recommend you to do. About 6 months ago I tried Lyrica at low dose and I hated it so I stopped it. Since then I gave Lyrica a another trial at high dose because I heard high dose was feeling different (more energy etc) .. for me it made the difference between a med that was making me feel bad and one that is actually changing (saving) my life.
Wish you best luck with Lyrica,
Marty
Posted by SLS on September 5, 2006, at 17:07:22
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by MARTY on September 5, 2006, at 15:32:29
Yes. I intend to ask my doctor to continue to increase the dosage of Lyrica. I mentioned to him 600mg last time I saw him. He has a few patients on 300mg. I have an appointment with him later in the week. I took 75mg yesterday. I had less cognitive side effects today. So far, so good.
- Scott
Posted by Daisey on September 7, 2006, at 12:22:32
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by MARTY on September 5, 2006, at 15:32:29
I have Thoracic Outlet Syndrome and have been taking Nurontin for 3 years.
I just started taking the Lyrica yesterday (75mg).
I had my second dose today (75mg).
I hope it doesn't cause me to gain weight.
Posted by willyee on September 7, 2006, at 15:28:01
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by Daisey on September 7, 2006, at 12:22:32
Also just to note,i was doing absolutly horrable today,and i tried to think back to how i was doing quite manageable all week and i went out and refilled my nuerontin.
I cant be sure of this,but i have recently used with parnate a partial approx 300 mg nuerontin/partial depakote approx 150 mg .
Drink some caffiene with this to fight off the more initial sedation however afterward if u sit u feel a sense of calm,from this point using pebble sized pieaces of klonopin or vice cersa soda for residue anxiety or sedating is optional,this seems to depend on the time of day,morning commonly would require a bit of the benzo afternoon im fighting off sleep so i dont have any problems there.
Im gonna lower parnate and use this anxiety method in between more,perhaps the too meds in conjunction have a synergy?
I just know benzos are really in my opinion best used in the smallest dose possable,in increments as needed,i find taking a benzo at a higher dose truly is not meeting my needs at all neiter for anxiety or depression,least now all my limbs are loose i can move freely,i dont feel that axle attatchment to my spine anymore,and at this point its alll i want. im fine with how i feel this very second,STAY STAY STAY but it wont.Anyway too early to tell but i do suspect this combo was reasonbable for me having a fair week last week so that would give it a weeks fair play under ones belt.
How many people are so exhausted playing this game......whew.
Posted by SLS on September 12, 2006, at 11:16:35
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by MARTY on September 5, 2006, at 15:32:29
Ok. Here's one. How about anorgasmia?
It is taking me longer and longer to reach orgasm as I increase the dosage of Lyrica. Hopefully, it will be a temporary effect.
- Scott
Posted by TJO on September 12, 2006, at 13:45:11
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 12, 2006, at 11:16:35
Hi Scott,
How about adding Wellbutrin? If the problem continues? But I seem to remember that you did not react well to it and it made you "worse". Hope I'm wrong about that.:-D.
Tammy
Posted by Crazy Horse on September 12, 2006, at 15:35:35
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 12, 2006, at 11:16:35
> Ok. Here's one. How about anorgasmia?
>
> It is taking me longer and longer to reach orgasm as I increase the dosage of Lyrica. Hopefully, it will be a temporary effect.
>
>
> - ScottPersonally, i have had no sexual problems at all w/Lyrica.
-Monte
Posted by KayeBaby on September 13, 2006, at 4:30:32
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 12, 2006, at 11:16:35
I have noticed lowered libido but not too bad.
When I adjusted to the new dose things worked pretty normally.This has been a very good med for me-it's just rather touch some times.
I think you will find luck with this one,Scott.
Peace,
Kaye
Posted by SLS on September 13, 2006, at 5:38:15
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by KayeBaby on September 13, 2006, at 4:30:32
Hi KB.
Thanks much for the response.
How much Lyrica are you taking?
- Scott
> I have noticed lowered libido but not too bad.
> When I adjusted to the new dose things worked pretty normally.
>
> This has been a very good med for me-it's just rather touch some times.
>
> I think you will find luck with this one,Scott.
>
> Peace,
> Kaye
Posted by TJO on September 13, 2006, at 6:27:21
In reply to Re: Lyrica (pregabalin) - Side Effects ? » KayeBaby, posted by SLS on September 13, 2006, at 5:38:15
Hi All.
Wikipedia mentioned that amantadine (Symmetrel) is used somtimes to treat anorgasmia from SSRI's. I took Symmetrel briefly for EPS from Risperdal, and the drug agreed with me, and didn't cause more problems than it solved. I'm not sure Lyrica is a SSRI, however.Tammy
Posted by poop'd-out on September 13, 2006, at 15:37:46
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 12, 2006, at 11:16:35
> Ok. Here's one. How about anorgasmia?
>
> It is taking me longer and longer to reach orgasm as I increase the dosage of Lyrica. Hopefully, it will be a temporary effect.
>
>
> - Scott
Hi Scott,
I just started Lyrica last week. I couldn't really tell you yet from experience. Some of the stuff that I have read about Lyrica here and there on the Web was that at low doses it could cause some sexual dysfunction, but that at higher doses it was prosexual? (600mg and up) I am only at 300mg alternating with my neurontin currently. I hope this medication gives you some relief!!
Beth
Posted by KayeBaby on September 13, 2006, at 21:37:00
In reply to Re: Lyrica (pregabalin) - Side Effects ? » KayeBaby, posted by SLS on September 13, 2006, at 5:38:15
Hey Scott!
I am taking 300mg total per day 150mg 2x daily.
However, I am experimenting with my dosage and timing.I wish it didn't have such a short half life. Every 6 hrs is a pain.
It has been a good med for me all in all.The sedation and goofy feeling really does pass and when I take it before bed I sleep sooo well. I wonder how much of the improvements I have experienced with Lyrica are attributable to simply getting some quality sleep ?
Hows it going with you?
I am looking forward to detecting some perky-ness in your posts soon!Peace,
Kaye
Posted by TJO on September 14, 2006, at 5:44:37
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by KayeBaby on September 13, 2006, at 21:37:00
Hi Scott,
This site had the mechanism of action of Lyrica-http://www.lyricapro.com/cwpb/appmanager/lyrica/lyricaDesktop?_nfpb=true&_pageLabel=lyrica_pro_mechanismofaction
And here it is touted as a replacement for Neurontin
http://www.drugdevelopment-technology.com/projects/pregabalin/
Thought the info on the Neurontin comparison might be helpful :-)Tammy
Posted by TJO on September 14, 2006, at 5:46:45
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by KayeBaby on September 13, 2006, at 21:37:00
Hiya,
and one more interesting place-http://www.epilepsy.com/medications/b_lyrica_most.html
Tam
Posted by yxibow on September 15, 2006, at 3:41:33
In reply to Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 1, 2006, at 7:29:58
> What side effects can I expect from Lyrica?
Everyone on this has a completely different angle.
Unfortunately it wasn't the Cat-V super-Neurontin replacer I wanted it to be. At a test dose (of course I'm on multiple medications including a reduced dose of Neurontin at the time to prevent seizures from over-GABA) of 50mg (like 1/6 of a target dose), it reduced my approx 20/20 to 20/40. As soon as it was removed, I was back to my normal vision.
Vision and focus impairment is a small but definately known side effect of Lyrica. It's even smaller but I think listed with Neurontin though I don't get much of any side effects from Neurontin.
Posted by SLS on September 15, 2006, at 6:21:20
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by yxibow on September 15, 2006, at 3:41:33
> > What side effects can I expect from Lyrica?
>
>
> Everyone on this has a completely different angle.
> Unfortunately it wasn't the Cat-V super-Neurontin replacer I wanted it to be. At a test dose (of course I'm on multiple medications including a reduced dose of Neurontin at the time to prevent seizures from over-GABA) of 50mg (like 1/6 of a target dose), it reduced my approx 20/20 to 20/40. As soon as it was removed, I was back to my normal vision.I understand that the vision disturbance often disipates with continued treatment.
I'm sorry Lyrica didn't work out for you. Are drugs that are potentially beneficial for fibromyalgia on your radar screen?
- Scott
Posted by yxibow on September 15, 2006, at 23:20:18
In reply to Re: Lyrica (pregabalin) - Side Effects ? » yxibow, posted by SLS on September 15, 2006, at 6:21:20
> > > What side effects can I expect from Lyrica?
> >
> >
> > Everyone on this has a completely different angle.
> > Unfortunately it wasn't the Cat-V super-Neurontin replacer I wanted it to be. At a test dose (of course I'm on multiple medications including a reduced dose of Neurontin at the time to prevent seizures from over-GABA) of 50mg (like 1/6 of a target dose), it reduced my approx 20/20 to 20/40. As soon as it was removed, I was back to my normal vision.
>
> I understand that the vision disturbance often disipates with continued treatment.
>
> I'm sorry Lyrica didn't work out for you. Are drugs that are potentially beneficial for fibromyalgia on your radar screen?
>
>
> - Scott
I'm not suffering from fibromyalgia. I have a rare somatiform disorder which causes things to appear brighter than they should be, contrast off, etc... going on 5 years, things are much better. Fluorescent, metal halide, and certain artificial lighting settings are still annoying to a degree.
I've been through most AEDs except for Lamictal. Trileptal just increased one of the few other odd sensory feelings (thirst/saliva) before reaching any notable dose. Lithium has not been tried and probably would be of little help.
Mostly therapy is focused more on goal orientation, returning to society more, (being that this came to my attention about the night of Nov 17. 2001 while attempting to drive in the mountains to the Leonid showers it is likely to have been triggered by my extreme reaction to 9/11) volunteer work, and eventually hopefully pushing the hyperawareness which is going on out of my head to a more background level by engaging in more activity. At least that is the current and probable theory. The one thing that can said in common about most of the medications I take is that they are sedating, which may contribute a percentage to their efficacy. The two main ones that seem to be the actors on the scene are Seroquel (D2 antagonism, the visual receptors which are even in the eye itself) and benzodiazepines, specifically Valium and Xanax (on a bad day), which demonstrably help "screen out" the information which most everyone could imagine if they actually thought about it. E.g., those new replacement traffic lights that are becoming more common in cities, with bright LEDs, someone could say, yes, that's rather bright, but it would be gone -- for myself, the "psychic pain" and the non-screening out of these items make them more miserable. Palinopsia does occur in the dark, like seeing images of cellphones, bright car consoles, bright TVs briefly for a snap to one direction or another. Haloform auras sometimes develop on objects at night briefly. When this first started, if someone took a flash picture of me, the flash would remain for 15 minutes. And I would be wearing sunglasses in nightclubs.
But I digress anyhow -- visual effects are something that can happen with Lyrica, I forget, around 5 or 10% maybe.
I wish you luck with it if you are still continuing on.-- tidings
Jay
Posted by SLS on September 16, 2006, at 2:55:16
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by yxibow on September 15, 2006, at 23:20:18
Hi Jay.
Thanks for sharing so much.
I always appreciate when you do.
I am just starting to contemplate "returning to society" despite my condition. I am working with a counselor to help me make this transition. I have not completely committed myself to this yet, but I am entertaining the thought.
> I wish you luck with it if you are still continuing on.
Thank you.
- Scott
Posted by TJO on September 16, 2006, at 6:14:30
In reply to Re: Lyrica (pregabalin) - Side Effects ? » yxibow, posted by SLS on September 16, 2006, at 2:55:16
> Hi Jay.
>
> Thanks for sharing so much.
>
> I always appreciate when you do.
>
> I am just starting to contemplate "returning to society" despite my condition. I am working with a counselor to help me make this transition.
I think thats GREAT!!!!!!!I have not completely committed myself to this yet, but I am entertaining the thought.
Keep thinking!!!
>
> > Tammy
Posted by ed_uk on September 16, 2006, at 9:53:52
In reply to Re: Lyrica (pregabalin) - Side Effects ? » yxibow, posted by SLS on September 16, 2006, at 2:55:16
>I am just starting to contemplate "returning to society" despite my condition. I am working with a counselor to help me make this transition. I have not completely committed myself to this yet, but I am entertaining the thought.
I think it's vital Scott. It could be highly beneficial for your condition.
Ed
Posted by SLS on September 16, 2006, at 10:38:55
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by ed_uk on September 16, 2006, at 9:53:52
> >I am just starting to contemplate "returning to society" despite my condition. I am working with a counselor to help me make this transition. I have not completely committed myself to this yet, but I am entertaining the thought.
>
> I think it's vital Scott. It could be highly beneficial for your condition.Thanks, Ed. It is helpful to get feedback from you.
- Scott
Posted by TJO on September 16, 2006, at 12:19:12
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by ed_uk on September 16, 2006, at 9:53:52
Hi Scott,
It is incredible the self-esteem boost, the feeling of being a productive member of society, and the loss of a feeling of isolation that one can get even from a volunteer job-that is what I gained from work yesterday for putting in only a few hours. Go for it!!!!!!!!And also you might want to consider a job coach to help ease the transition, as well as your counselor.
Tammy
Posted by SLS on September 17, 2006, at 16:25:28
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by TJO on September 16, 2006, at 12:19:12
Crap.
I've been taking 3 times as much of this stuff as I am supposed to. My doctor and I agreed verbally that I should be taking 25mg t.i.d. at an earlier visit. What was dispensed to me was 75mg t.i.d. The script was written that way. My doctor wrote the script in error. I never bother to check the bottle. When we agreed to 75mg t.i.d. at my most recent visit. Insurance wouldn't pay for it. So I figured they wanted me to finish what I had left of what I thought were 25mg. So I've been taking 3 pills t.i.d. I moved up pretty quick too. That's 675mg.
I feel a little dopey. A little intoxicated. That's about it.
I wish I could say that I were feeling batter. I don't.
I have to reduce my dosage now. I'm screwed, though. I won't have enough to make it until my next refill. Insurance won't cover a premature request. I hope this is a fun ride.
- Scott
Posted by yxibow on September 17, 2006, at 18:42:57
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 17, 2006, at 16:25:28
> Crap.
>
> I've been taking 3 times as much of this stuff as I am supposed to. My doctor and I agreed verbally that I should be taking 25mg t.i.d. at an earlier visit. What was dispensed to me was 75mg t.i.d. The script was written that way. My doctor wrote the script in error. I never bother to check the bottle. When we agreed to 75mg t.i.d. at my most recent visit.Insurance wouldn't pay for it. So I figured they wanted me to finish what I had left of what I thought were 25mg. So I've been taking 3 pills t.i.d. I moved up pretty quick too. That's 675mg.
3 pills 75mg t.i.d. should be 225mg.. are you taking more than 3 75mg t.i.d. ? Oh.. good grief now I see what is going on... you're taking 225mg t.i.d. or "75mg 3 caps t.i.d."
>
> I feel a little dopey. A little intoxicated. That's about it.At 675mg from 75mg and 225mg I would say completely intoxicated :( but survivable.
> I wish I could say that I were feeling batter. I don't.
I'm sorry to hear this -- I think the feeling better part is about the dosage now, because any time you spike a dosage in certain medications you can get nausea, all sorts of psychoactive side effects.
> I have to reduce my dosage now. I'm screwed, though. I won't have enough to make it until my next refill. Insurance won't cover a premature request. I hope this is a fun ride.
Insurance -- I dont know about yours, perhaps they aren't as nice (and dont reveal their name online to protect your rights on HIPAA in your answer), usually will pay about a 3-4 day leeway in filling to account for any lost pills, month changes (e.g. averaging for February, etc.).I would ask your pharmacist to see if they can push your insurance to agree to a shift, if anything on the grounds that it is an AED and one should not withdraw from any AED "cold turkey".
I'm gathering you see your doctor once or twice a month then because if it was once a month you should certainly be able to refill the medication unless you get 90 day refills, and even then I am sure you can convert to 30 day? I'm just posturing here.
I wouldn't have the pharmacist tell them how much you're taking now (675), but you're certainly entitled to a proper dose through a dosage error.
I hope you feel better- Jay
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Dr. Bob is Robert Hsiung, MD,
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