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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 25 of 68. This is the beginning of the thread.
Posted by SLS on September 1, 2006, at 7:29:58
What side effects can I expect from Lyrica?
One person reported significant memory impairments at 600mg. Has anyone else experienced this?
- Scott
Posted by MidnightBlue on September 1, 2006, at 9:32:31
In reply to Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 1, 2006, at 7:29:58
I have heard blurred vision, weight gain, and memory/cognitive problems. Also do NOT take if you are pregnant, want to become pregnant, or want to father a child soon.
My son tried it for nerve pain and didn't like the way it made him feel.
MB
Posted by Crazy Horse on September 1, 2006, at 10:06:10
In reply to Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 1, 2006, at 7:29:58
> What side effects can I expect from Lyrica?
>
> One person reported significant memory impairments at 600mg. Has anyone else experienced this?
>
>
> - ScottHi Scott,
The only side effect i have had on Lyrica was some sedation/drowsiness at low dose, when the dose got up to 3-400 mgs. this disappeared and was replaced with an increase in energy. At 600 mgs. a day, i have no side effects and my memory is excellent...much better than my wifes, who is very intellegent and 8 years younger than i am.:)
I am excited you are taking the "Lyrica Plunge" Scott, and hope and will pray that it works well for you!
-Monte
Posted by Phillipa on September 1, 2006, at 11:09:36
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by Crazy Horse on September 1, 2006, at 10:06:10
It's designed for nerve pain right? An offshoot is the calming effect I read. Love Phillipa
Posted by willyee on September 1, 2006, at 12:44:33
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by Crazy Horse on September 1, 2006, at 10:06:10
> > What side effects can I expect from Lyrica?
> >
> > One person reported significant memory impairments at 600mg. Has anyone else experienced this?
> >
> >
> > - Scott
>
> Hi Scott,
>
> The only side effect i have had on Lyrica was some sedation/drowsiness at low dose, when the dose got up to 3-400 mgs. this disappeared and was replaced with an increase in energy. At 600 mgs. a day, i have no side effects and my memory is excellent...much better than my wifes, who is very intellegent and 8 years younger than i am.:)
>
> I am excited you are taking the "Lyrica Plunge" Scott, and hope and will pray that it works well for you!
>
> -Monte
Your killing me with this lyrica,i am regreting i let my doc off so easy refusing to try it.I believe you said ....its so different than Nuerontin that it shouldent be mentioned togther,wow thats quite a statement,have u taken Nuerontin,i ask because rather than let me try lyrica which i asked 3 times for,she stock piled the Nuerontin to over 3 grams which i dont take,so i ask in your opinion do you believe there is any way i could get the Nuerontin to mimick the effect of lyrica in anyway??
I cant believe this new doc,shes shot down every idea of mine,ever since my old doc retired ive gotten less then no where.
Posted by SLS on September 1, 2006, at 13:26:43
In reply to Re: Lyrica (pregabalin) - Side Effects ? » Crazy Horse, posted by willyee on September 1, 2006, at 12:44:33
Perhaps you can begin to collect stuff regarding the use of pregabalin in fibromyalgia (FMS) and chronic fatigue syndrome (CFS) and demonstrate the overlap of symptomology with depression - energy, mood, etc.
- Scott
Posted by SLS on September 1, 2006, at 13:28:41
In reply to Re: Lyrica (pregabalin) - Side Effects ? » willyee, posted by SLS on September 1, 2006, at 13:26:43
> Perhaps you can begin to collect stuff regarding the use of pregabalin in fibromyalgia (FMS) and chronic fatigue syndrome (CFS) and demonstrate the overlap of symptomology with depression - energy, mood, etc.
Also its use in generalized anxiety disorder (GAD).
- Scott
Posted by ed_uk on September 1, 2006, at 15:16:13
In reply to Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 1, 2006, at 7:29:58
Scott, have you started Lyrica yet? If so, what dose are you taking and how are you finding it?
Ed
Posted by SLS on September 1, 2006, at 15:29:08
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by ed_uk on September 1, 2006, at 15:16:13
Hi Ed.
> Scott, have you started Lyrica yet? If so, what dose are you taking and how are you finding it?
I started Lyrica last night with a single 25mg dose. I will take my second 25mg dose tonight. I slept well. Today has been better than the several days previous. It is difficult to assess the contribution of Lyrica to this. I did feel something different early in the day, though. It was not unpleasant. I might move up to 50mg tomorrow.
- Scott
Posted by Crazy Horse on September 1, 2006, at 16:57:42
In reply to Re: Lyrica (pregabalin) - Side Effects ? » Crazy Horse, posted by willyee on September 1, 2006, at 12:44:33
> > > What side effects can I expect from Lyrica?
> > >
> > > One person reported significant memory impairments at 600mg. Has anyone else experienced this?
> > >
> > >
> > > - Scott
> >
> > Hi Scott,
> >
> > The only side effect i have had on Lyrica was some sedation/drowsiness at low dose, when the dose got up to 3-400 mgs. this disappeared and was replaced with an increase in energy. At 600 mgs. a day, i have no side effects and my memory is excellent...much better than my wifes, who is very intellegent and 8 years younger than i am.:)
> >
> > I am excited you are taking the "Lyrica Plunge" Scott, and hope and will pray that it works well for you!
> >
> > -Monte
>
>
> Your killing me with this lyrica,i am regreting i let my doc off so easy refusing to try it.
>
> I believe you said ....its so different than Nuerontin that it shouldent be mentioned togther,wow thats quite a statement,have u taken Nuerontin,i ask because rather than let me try lyrica which i asked 3 times for,she stock piled the Nuerontin to over 3 grams which i dont take,so i ask in your opinion do you believe there is any way i could get the Nuerontin to mimick the effect of lyrica in anyway??
>
> I cant believe this new doc,shes shot down every idea of mine,ever since my old doc retired ive gotten less then no where.
>
>
>I was on Neurontin back in 1999 for 6 months. I took 1200 mgs. a day and felt absolutely NOTHING! In my opinion, there is no comparison between Lyrica and neurontin. Lyrica (for me) is a miracle drug! Okay, bottom line..I LOVE LYRICA..LOL!
-Monte
Posted by Phillipa on September 1, 2006, at 21:05:58
In reply to Re: Lyrica (pregabalin) - Side Effects ? » Crazy Horse, posted by willyee on September 1, 2006, at 12:44:33
Scott your old doc retired? I'm sorry . Love Phillipa
Posted by Cairo on September 3, 2006, at 9:49:53
In reply to Re: Lyrica (pregabalin) - Side Effects ? » ed_uk, posted by SLS on September 1, 2006, at 15:29:08
My only suggestion is to ramp up Lyrica slowly. I had extreme unsteadiness, spaciness and almost a euphoric feeling when I tried to increase the dose quickly. I was told to wait one week before a dose increase, but I'm pretty sensitive to meds.
I can't take Lyrica during the day, however, because of the unsteadiness and feelings of depersonalization. I do experience some anti-anxiety effect. Muscle relaxation, which is the main reason I started it, poops out pretty quickly for me. This also happened with Neurontin.
I definitely like it as an adjunct to trazodone for sleep. A repeat sleep study with me on 150mg Lyrica and 50mg trazodone showed a great sleep profile.
As for Fibromyalgia pain, much of my pain comes from muscle tightness and trigger points. Lyrica helps some initially, then goes away, as I've said. But I know of someone who says it has made all the difference in the world for her FMS pain. I have anxiety/panic issues going on now, so I may be a different subset of FMS.
Good luck.
Cairo
> I started Lyrica last night with a single 25mg dose. I will take my second 25mg dose tonight. I slept well. Today has been better than the several days previous. It is difficult to assess the contribution of Lyrica to this. I did feel something different early in the day, though. It was not unpleasant. I might move up to 50mg tomorrow.
>
>
> - Scott
Posted by Crazy Horse on September 3, 2006, at 10:15:52
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by Cairo on September 3, 2006, at 9:49:53
> > I started Lyrica last night with a single 25mg dose. I will take my second 25mg dose tonight. I slept well. Today has been better than the several days previous. It is difficult to assess the contribution of Lyrica to this. I did feel something different early in the day, though. It was not unpleasant. I might move up to 50mg tomorrow.
> >
> >
> > - Scott
>
>As always, psych. meds effect different people differently. It's definately not an all for one type of situation w/these meds.
For me, an every 3rd day titration/addition of 50 mgs worked beautifully. Also, now at 300 mgs b.i.d., for 2.5 months, i have not developed any tolerance at all. This dosing schedule works great to aleviate depression and anxiety, with the additional benefits of increased energy a pro-social effect, and mood elevation. For me, in 26 years of depression, anxiety, some ocd and social anxiety, i have found NOTHING BETTER, and that includes my once beloved Parnate that i had to stop due to intolerable side effects.
-Monte
Posted by SLS on September 3, 2006, at 10:24:25
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by Cairo on September 3, 2006, at 9:49:53
Hi Cairo.
Thanks for the suggestions and the well-wishes.
> As for Fibromyalgia pain, much of my pain comes from muscle tightness and trigger points. Lyrica helps some initially, then goes away, as I've said. But I know of someone who says it has made all the difference in the world for her FMS pain. I have anxiety/panic issues going on now, so I may be a different subset of FMS.
Well, that really stinks. Despite my adverse experience with it, I have seen a video demonstrating the effectiveness of sibutramine (Meridia) in the treatment of FMS on actual patients. The doctor who advocates its use here is Peter Mueller, MD in Princeton, NJ. On a simplistic level, it is an SNRI like Effexor or Cymbalta (both of which I'm sure you've explored). It does separate itself from those two drugs pharmacologically, though. One person who responded favorably showed dramatic improvements in pain and trigger points, energy, cognition, and depressed mood and dysphoria.
Peter S Mueller Pa
601 Ewing St # B3
Princeton, NJ 08540
(609) 924-4061
- Scott
Posted by SLS on September 3, 2006, at 10:37:42
In reply to Re: Lyrica (pregabalin) - Side Effects ? » Cairo, posted by Crazy Horse on September 3, 2006, at 10:15:52
Hi Monte.
> For me, in 26 years of depression, anxiety, some ocd and social anxiety, i have found NOTHING BETTER, and that includes my once beloved Parnate that i had to stop due to intolerable side effects.
Can you describe in more detail what your depression is like?
Thanks.
Mine comprises anergia, anhedonia, loss of interest, amotivation, low libido, psychomotor retardation, cognitive slowing and impairment in concentration, impaired memory, hyperphagia, and hypersomnia.
- Scott
Posted by Crazy Horse on September 3, 2006, at 10:48:54
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 3, 2006, at 10:37:42
> Hi Monte.
>
> > For me, in 26 years of depression, anxiety, some ocd and social anxiety, i have found NOTHING BETTER, and that includes my once beloved Parnate that i had to stop due to intolerable side effects.
>
> Can you describe in more detail what your depression is like?
>
> Thanks.
>
> Mine comprises anergia, anhedonia, loss of interest, amotivation, low libido, psychomotor retardation, cognitive slowing and impairment in concentration, impaired memory, hyperphagia, and hypersomnia.
>
>
> - ScottMy Depression: Very low energy, overwhelming sadness and negativity, no motivation, anti-social, excessive sleep (12-14) hours a day, suicide ideation, anxiety, ruminations, anger and fear, overwhelming feeling of worthlessness, inability to take on daily responsibilites, low libido and an over-all lack of interest in life and all activities. In a nutshell: Hell on earth.
-Monte
p.s. this is a small list..lol.
Posted by SLS on September 3, 2006, at 11:10:31
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by Crazy Horse on September 3, 2006, at 10:48:54
Hi Monte.
> > Can you describe in more detail what your depression is like?
> >
> > Thanks.> My Depression: Very low energy, overwhelming sadness and negativity, no motivation, anti-social, excessive sleep (12-14) hours a day, suicide ideation, anxiety, ruminations, anger and fear, overwhelming feeling of worthlessness, inability to take on daily responsibilites, low libido and an over-all lack of interest in life and all activities. In a nutshell: Hell on earth.
>
> -Monte
>
> p.s. this is a small list..lol.
Ouch.I'm glad you have been freed from these things. They really are shackles upon one's consciousness and mobility.
- Scott
Posted by anhedonic on September 3, 2006, at 14:08:18
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 3, 2006, at 10:37:42
I share the same symtoms as you Scott. 100%
Have you tried Emsam yet? It's next on my list, and have seen some good responses from people on here w/ similar symptoms.Shane
> Hi Monte.
>
> > For me, in 26 years of depression, anxiety, some ocd and social anxiety, i have found NOTHING BETTER, and that includes my once beloved Parnate that i had to stop due to intolerable side effects.
>
> Can you describe in more detail what your depression is like?
>
> Thanks.
>
> Mine comprises anergia, anhedonia, loss of interest, amotivation, low libido, psychomotor retardation, cognitive slowing and impairment in concentration, impaired memory, hyperphagia, and hypersomnia.
>
>
> - Scott
Posted by SLS on September 3, 2006, at 19:09:54
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by anhedonic on September 3, 2006, at 14:08:18
Hi Shane.
> I share the same symtoms as you Scott. 100%
> Have you tried Emsam yet?No. I am having a difficult time choosing between Emsam or going back to Nardil and trying to augment it with other drugs.
Have you tried any MAOI yet?
- Scott
Posted by anhedonic on September 4, 2006, at 13:06:52
In reply to Re: Lyrica (pregabalin) - Side Effects ? » anhedonic, posted by SLS on September 3, 2006, at 19:09:54
Hi Scott,
I haven't tried any MAO yet, other than oral Selegaline years ago to no effect. I think most pdocs today don't consider them much anymore, or just don't want to take the risk. I see a new pdoc on Sept. 11th, my first one in 3 years. Hopefully he is open to suggestions. I am not taking anything right now, how about yourself? I'm also considering ordering Tianeptine (Stablon), if I don't get the Emsam for some reason.Shane
> Hi Shane.
>
> No. I am having a difficult time choosing between Emsam or going back to Nardil and trying to augment it with other drugs.
>
> Have you tried any MAOI yet?
>
>
> - Scott
Posted by SLS on September 4, 2006, at 15:42:41
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by anhedonic on September 4, 2006, at 13:06:52
> I am not taking anything right now, how about yourself?
I'm currently taking:
Lamictal 150mg
nortriptyline 100mg
Abilify 10mg
Topamax 100mg
Lyrica 75mg
> I'm also considering ordering Tianeptine (Stablon), if I don't get the Emsam for some reason.I keep forgetting about that drug. It's on my list, but I haven't spoken to my doctor about it yet.
I hope this new doctor works out well for you.
- Scott
Posted by Anhedonic on September 4, 2006, at 16:34:11
In reply to Re: Lyrica (pregabalin) - Side Effects ? » anhedonic, posted by SLS on September 4, 2006, at 15:42:41
Scott,
do you have an epileptic condition as well? Three of the meds you take are used as anti-seizure meds as well as off label. I actually am on one medication, Keppra, which works great for my epilepsy. I don't know that it has any mood altering affect though. Maybe a mild stablizer.
I'm not sure where your located, but if it's the USA, you're gonna have to order the Tianeptine from overseas as it's patent has run out over here.Shane
> I'm currently taking:
>
> Lamictal 150mg
> nortriptyline 100mg
> Abilify 10mg
> Topamax 100mg
> Lyrica 75mg
>
>
Posted by SLS on September 4, 2006, at 19:57:07
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by Anhedonic on September 4, 2006, at 16:34:11
> Scott,
> do you have an epileptic condition as well?No. Just bipolar disorder.
> Three of the meds you take are used as anti-seizure meds as well as off label. I actually am on one medication, Keppra, which works great for my epilepsy.
I tried Keppra. I found it to be destabilizing and depressogenic at higher dosages while being somewhat antidepressant at lower dosages.
Lyrica made me feel kind of dopey and really impaired my memory for awhile today. I wasn't too happy with that. I hope this is just a passing side effect.
Thanks for the info on tianeptine.
- Scott
Posted by hattree on September 5, 2006, at 12:59:06
In reply to Re: Lyrica (pregabalin) - Side Effects ? » Anhedonic, posted by SLS on September 4, 2006, at 19:57:07
I've been taking Neurontin for several years with some minor success. About to try Lyrica. Do you think I need to stop the Neurontin first? Substitute a dose of Lyrica for the Neurontin? Take them both at the same time?
?
Posted by Crazy Horse on September 5, 2006, at 14:09:30
In reply to Neurontin/Lyrica together, posted by hattree on September 5, 2006, at 12:59:06
> I've been taking Neurontin for several years with some minor success. About to try Lyrica. Do you think I need to stop the Neurontin first? Substitute a dose of Lyrica for the Neurontin? Take them both at the same time?
>
> ?The Lyrica will replace the neurontin. Think of the Lyrica as a new improved neurontin, that is basically what it is. It is 3-10 times more powerful than neurontin. Lyrica mimics GABA. My prediction is eventually neurontin will become obselete, as Lyrica is so way more effective then neurontin, in all forms of treatment potential. I'm talking from experience as well, as i have been on both of these medications. For me, Lyrica works very well, neurontin did nothing for me.
-Monte
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