Psycho-Babble Medication Thread 13781

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Re: Effexor XR - Some Advice Desperately Needed.HELP.

Posted by Chandelen on December 31, 2003, at 0:56:04

In reply to Effexor XR - Some Advice Desperately Needed.HELP., posted by Gummybear on December 28, 2003, at 14:59:56

> Hi, I am 23 years old and have developped GAD and major depression about 4 weeks ago. I have since been on Effexor XR at 37.5mg for one week, 75mg for another week, and now 150mg.
>
> When I increased my dose from 75mg to 150mg, I have started to get uncontrollable muscle twitches. It's really scaring me.... Do these go away????? They are not major but the worst part is that they are uncontrollable... have I messed up my nervous system somehow??? Please help....
>
> Also, I wake up constantly during the night - I think this is from the Effexor XR.... does this also go away???? Will I ever be able to sleep again???
>
> The Doctor has prescribed 25mg of Seroquel at night, which I have been taking... can this drug have serious side effects on such a low dose??? it's an anti-phsycotic drug which I am very reluctant in taking.
>
> Please any help would be greatly appreciated??? Do this problems go away with time??? It's only been 4 weeks.... thanks,
>
> G. Bear.

Hi Gummy Bear!,...First, this is very important: please IMMEDIATELY QUIT taking the Seroquel if you have any twitching! And please tell your doctor about the twitching. If he keeps you on Seroquel at that point, it's time to find another doctor.

For me, the Effexor side effects went away
in a few weeks, but if they would have persisted I would have switched back to Serzone for anxiety disorders. I am now on Wellbutrin/Serzone plus 2.5mg Buspar 2X/day. The Wellbutrin stimulation counteracts the Serzone tiredness. Anxiety greatly improved!
The sleep problem went away with Effexor for me, but I quit due to a rare side effect of kidney
pain/stone. So it was back to Serzone alone, which is great for sleep, but really ...zoned me out during the day. The Wellbutrin has been awesome.

As for Seroquel, I would immediately stop taking it, as it can cause permanent tardive dyskinesia, a terrible condition, and tell your doctor about the twitches. Sorry to shout up at the top, but that and be an extremely dangerous high risk drug, and there are much better drugs to help you sleep with no risk of a horrible permanent condition.

Take care,
Chandelen

 

Re: Effexor XR - Some Advice Desperately Needed.HELP.

Posted by joeyD on December 31, 2003, at 8:09:23

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP., posted by Chandelen on December 31, 2003, at 0:56:04

Hey guys sorry about taking up time here. I hope I'm posting in the right place. I have a few questions. I have just started taking 75 mg of Effexor XR about a week ago for GAD and mild depression. Since I started I have not been able to sleep, however I have been able to function surprisingly well. As of last night I have been having some extreme OCD symptoms!! I could not even think about going to sleep last night so I took 1mg of Klonopin and when I woke up this morning the OCD is still here but even worse! Its driving me crazy! I never had these feelings before and its really bothering me. BTW, they are not dangerous in any way to others or myself. Could the Effexor be causing this? Also, does this med generally cause extreme aggitation? I've been getting angry extremely easilly for a few days now. Sorry to bother you guys about this stuff but my doctor wont talk to me over the phone and my appointing is not until another two weeks. And yes, I am currently looking for a new one.

Thanks in advance!!

Joey

 

Re: Effexor XR - Some Advice Desperately Needed.HELP. » Gummybear

Posted by Zellie on December 31, 2003, at 8:24:55

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP., posted by Gummybear on December 28, 2003, at 19:25:08

Hi, Gummybear. Cool name.

The twitches you are experiencing are likely intesified by the quick titration upwards (dosage increase) of the Effexor. My doc had one full month between the increments, so my body had time to adjust to each new dosage level. Many docs have a one-week titration of Effexor. It intensifies the side-effects that way.

I still have twitches as I am falling off to sleep, and during my sleep (I had the odd twitch before the Effexor, too...my husband has the odd twitch, too, as he is falling off to sleep, and he has never taken any meds and has no psychological issues). So, twitching per se is normal, I think. I just twitch a little more now than previously.

As for altering one's personality, I can only speak here for myself when I say that the Effexor has not altered my personality....it was the anxiety and depression, OCD and ADHD that altered my personality!! Now that I have been on Effexor since last spring, I am able to be who I really am, and NOT be edgy, irritable, annoyed, tense, worried all the time, over-controlling, etc. etc. etc. It's been wonderful for me.

I am on 150 mg Effexor XR, and 100 mg Wellbutrin. The Wellbutrin is to further target the ADHD, and to counter the sexual side-effects of the Effexor.

I still feel slight depression during PMS for a week each month, but it sure beats feeling it to the max, 365 days a year, all my life!!

I am a candidate for never coming of the meds. I had an early onset of all my disorders, for sustained periods. Should I ever have the need to switch from the Effexor, I shall heed the warnings of the postings here to go reeeeeeally slowly titrating off (several months at each decreased dosage), to minimize the side-effects.

Hope all goes well with you.

Kindest regards,
Zellie

> Hey drangonfly and maxx, thanks for your input. The Effexor XR HAS actually helped me since I'm doing 10X better than I was 3 weeks ago where I couldn't get out of bed all day and was crying everyday. Now I'm not crying anymore and am starting to do day to day activities again... though I still have anxiety and attacks and then get down about them. But progress has been made and that's why I'm hopefull and sticking to them.
>
> The twitches really freak me out though... anybody else on Effexor XR experience them and did they ever go away????
>
> And what did you mean that these meds can alter a person's personality permanently???? that's sooo scary??? Has anybody noticed their personality change???? I've changed but that's a result of my sudden bout of anxiety and depression not the meds.... also, my "core" self I still believe is the same.
>
> I'm really reluctant to be taking the Seroquel (anti-phycosis med.) - the DR. told me to take 25mg at night to rid me of my constant worrying thoughts... but it makes me feel like their is a void in my head, or just emptiness and in the morning I am groggy. But I'll be stopping the Seroquel this week.....
>
> Please share any experiences you've had with Seroquel and Effexor XR side effects - like the twitching....
>
> Thanks a millionn,
> G. Bear.

 

Re: Effexor XR - Some Advice Desperately Needed.HELP.

Posted by maxx44 on December 31, 2003, at 15:06:43

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP., posted by joeyD on December 31, 2003, at 8:09:23

odd your dr. won't talk, save in person. he probably wants to look you over, or is perhaps not the right dr. if you're on medicare or any sort of 'bargain' treatment funding, that usually results in a lower level of care vs. cash. i'm termed 'the fine-print man',if there's a paradoxical rare reaction, it often gets me. sounds like the med is not for you. don't just quit, but if my dr. refused contact with such adverse effects i'd lower the dose myself. wellbu made me aggressive within an hour of 1st intake--actually it made me 'dangerous'---i hit the nearest 'big-bucks' er. i have insurance. as for klonopin, watch out. some may need a benzo, just to function, but the current thinking is 'short-term use only' for the average client. check out www.benzos.org.uk and see what i mean. you're 'adverse reactions' deserve immediate attention. given your state i feel no ethical dr. would refuse contact, with rare exceptions.

 

Re: Effexor XR - Some Advice Desperately Needed.HELP.

Posted by maxx44 on December 31, 2003, at 15:46:35

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP., posted by Chandelen on December 31, 2003, at 0:56:04

well, maxx here--thank you chandelin. both minor tranqs (benzos) and major ones (neuroleptics)may become trouble. TD may show up rapidly, but usually after long-term neuroleptic use. however, the newer 'atypicals' as zyprexa, risperdal, etc., or the old ones, haldol, thorazine, etc. may produce 'neuroleptic malignant syndrome'. at any time, as TD, but often hit 'affective disorder' people more than 'thought disorder' folk. classic NMS has swift onset and requires immediate hospitalization. as for the 'atypicals', i was hit by risperdal-induced 'atypical neuroleptic malignant syndrome'--a slower deal, i had incontinence in 24 hours, intermittent high fever, and increasing leg rigidity. 'ANMS' was an apparent 'unknown' during my 90 day trial for refractory depression. my drs. thought i looked better, calmer,less hypomanic and ignored my bitching about being 'out-cold' for 18 hours/day, incontinence, loss of mental status, rigidity and odd 'flu-like' fevers that came and went. only when i showed them a print-out on atypical neuroleptic syndrome and its 'spectrum' aspect vs. classic NMS did they understand. 3 years later i have yet to recover full mental status. harm was done. your advice to stop a major tranq, IMHO was well-put in this case.

 

Re: Anyone had success on Effexor XR?

Posted by maxx44 on December 31, 2003, at 15:59:14

In reply to Re: Anyone had success on Effexor XR? , posted by Chandelen on December 31, 2003, at 0:38:23

interesting on inderal---it is often used by 'classical pianist'and others the night before a performance, to deal with 'hand-tremor'. just knocked me out for 24 hours. the 'unique' aspects of every single nervous system should always be considered. snowflakes all make the ground white--yet each snowflake is unique----savvy?

 

Joey

Posted by Jaynee on December 31, 2003, at 16:03:47

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP., posted by joeyD on December 31, 2003, at 8:09:23

Hi Joey, I tried Effexor XR for about 4 to 5 weeks, when I finally quit I was taking 75mg. I had really bad anxiety and insomnia, plus constipation, blurred vision, dehydration, felt awful basically. I decided to quit and go back to Celexa and have been fine since.

I know it works wonders for some but the side-effects were just too much for me, and I felt if it wasn't making things better in 4 weeks, and actually making things worse, then there was no point in taking it. You might want to give it more time, but remember there are other meds out there that may not give you as much trouble with side-effects.

Good luck.

ps, Celexa was the first AD I ever tried, it is not perfect, but my symtoms got better in the first week, not worse, like they did with effexor.

 

Re: Joey

Posted by maxx44 on December 31, 2003, at 18:11:09

In reply to Joey, posted by Jaynee on December 31, 2003, at 16:03:47

wise advice--when 'side-effects' are that intense, IMHO most drs. would switch you. re:celexa---seems there is 'new' version i read of. 'improved'. it's basically 1/2 the molecule of celexa. do a search, you'll find the data. my expertise is the old tcas, maois, trazadone ADs. tried others--got trouble---ssris knock me out. re: your AD adverse reactions, i advise a dr. call. why? even sudden stopage of the 'wrong' drug is known to cause problems---you're dr. will advise you of any such risk. and search the net, in case he doesn't. you may need days or weeks of lowering dose, then a 'washout' period---then the new AD. good luck and be careful.

 

twitching and doc contact

Posted by Lyrical13 on January 1, 2004, at 9:17:32

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP. » Gummybear, posted by Zellie on December 31, 2003, at 8:24:55

OK..this is a 2-part response to several messages. First re: twitching. My legs usually twitch/jump in the evening..I just can't keep them still and it's very annoying. But it seems to happen regardless of whether I have taken my meds yet. (I take 225mg Effexor, 50mg Seroquel at bedtime and 100mg Synthroid in AM) It usually happens when I'm laying on the couch vegging out and winding down around 10PM or so. But I've had this leg twitching stuff before when I wasn't on my meds. It seemed to happen when my blood sugar was out of whack. So I don't know for sure if it has to do with the meds or not. When it was happening before these meds, it was once in a blue moon. Now it is almost every night. But once I take meds and go to bed, no problems. Anyone have any thoughts about this? It seems to have started since I started Seroquel. I have been on Effexor for a year and just started Seroquel a couple months ago.

Now, re: joey's doc. I hope you are successful in finding a new doc. I just went through a similar experience and changed docs and am SOOOO happy that I did. I had my previous doc kind of by default. I was working with a doc (we'll call him Dr. T.) for a few years and then he moved to the other side of the state. He gave me a list of all the docs in my town..I asked him to narrow it down to the 1 or 2 that he thought I would work well with. Dr. M. was one that he recommended. So I started with Dr. M. in fall of 2001. He was a nice doc when things were going well and he did get me off Serzone (the 'zone' part of that med was accurate for me...) and onto Effexor which has been wonderful for me. But when I was having a crisis he wasn't very responsive. He was very inconsistent in getting back to me. He would talk to me on the phone but sometimes he called back right away..sometimes it was 3 days. That's not good enough when you're in a crisis. I'm sure all of you know that when you're feeling desperate and falling apart an hour can feel like an eternity. His voicemail said go to the ER or call the psych nurse if it's an emergency..well I didn't think it was that much of an emergency that I needed to go to the ER...I live in a small town. everyone knows everyone else's business...I really didn't feel like entering gossip central for the way I was feeling at that time, but I definitely needed assistance. All I needed was for him to tell me how to adjust my meds to feel better. That shouldn't require an ER visit.

Well, I put up with it for the first major crisis in fall of 2002. I couldn't get in to see him for a month and I was falling apart at work. I missed 10 days of work between Sept and Dec. My original doc (Dr. T) would have squeezed me in for an appt within a few days if I was having such a crisis. This doc couldn't even consistently return a phone call. Well, this fall when I started having problems I decided enough was enough. In aug the depression started and I had an appt within a couple weeks so I just went to the appt and we increased the effexor from 75 to 150. It helped for a while but as soon as work started (I work at a school) the anxiety went through the roof. He said to take Attivan (0.5 to 1mg every 6 hrs) which helped some. 3 weeks after upping Effexor dose I was falling apart at work. He said to give it another week. So I did. fAlling apart even worse. Crying jags at work, difficulty being alone at all, starting to having suicidal thoughts...he said "give it another week" again. I was saying I needed to up the dose. Now, I am soemone who is usually very cautious about meds and wants to be on as low a dose as possible. I rarely ask to up the dose. That I was begging to up the dose should have clued him in if he was paying attention. He was very condescening to me on the phone saying that 150 was the dose that worked last year and it should still work and that time of year shouldn't matter (for the past 10 years my worst time has been sept thru jan. 150 was a great dose from jan thru april. after that 75 worked wonderfully...got a little hypomanic around march..but that's another story)

Anyway, I called him back the next day, (after talking to him on the phone on a tues eve and he's being condescending and saying to just give it another week...I'm sobbing uncontrollably and he's saying "wait") Wed I called back and of course he wasn't available so I left a voicemail saying that I had talked to my husband and close friends who had seen how well I did on 150 last year and I wasn't nearly that good right now and i was trying to be pro-active, shouldnt' have to have a total breakdown before I got help and that I felt it was time for a medical intervention..time to increase Effexor. He didnt' call back for 3 DAYS...In fact, I showed up at his office with my husband on Fri afternoon. All of a sudden his tune changed and upping the Effexor was a good idea...but he thought I should enter the day treatment program. At this point I was already trying to set up an appt with another doc. When he saw we weren't going for the day treatment thing (I really didnt' trust him or respect him at this point...why waste my time and miss all that work plus it would bill as a hospitalization....and the whole small town thing again...) All of a sudden he was available for weekly appts. Where the heck were weekly appts last year when I was falling apart and missing so much work?!!!! I agreed to weekly appts and we upped my meds. To make a short story long..... I changed to Dr. Z within a few weeks...just bided my time with weekly appts with Dr. M. until I could get set up with a new doc and make sure I felt comfy with new doc....Best move I ever made in my life. It's hard to make a big change like that when you are in a crisis but if your gut says that you aren't getting the treatment you think is appropriate, your gut is probably right. I should have listened to my gut a year ago.

Dr. Z. explained chronic major depressoin and treatment options to me...augmentation etc. Laid out all my options and pros and cons of various meds and then asked me what I wanted to do. Admittedly, it was info overload but he was cool with me taking a week to think about it. When I came back and told him what i'd like to try, he gently pushed me in a direction that I was a bit wary about (Seroquel...he wanted me to try it short-term because it would boost the Effexor and get me feelign better quickly..plan was that I also start Synthroid..it would take a while to get to a level..once it was up, then stop Seroquel...this plan has since changed...at last appt based on info I gave him he now thinks I'm BP2 and not GAD/depression...funny I brought up same concerns with Dr. M last spring..he labeled it hypomanic but blew it off!....if he had expressed concern like Dr. Z. and responded with approp treatment I could have saved us hundreds of dollars in spending sprees.......

Anyway, when I see Dr Z in a couple weeks we plan to d/c Seroquel and I think Synthroid also and start Lamictal.. Eventually will start backing off slowly from Effexor...his predicted end result med combo is either Lamictal alone or with a low dose of Effexor for depression aspect. (we talked about this at dec appt but I didn't want to mess with my meds over the holidays and be all whacked.

HOpefully Joey can get with a different doc. It doesn't sound like your current doc is very responsive. Shouldn't be blowing you off esp when you're having such scary side effects. BTW I only missed a total of one day of work this fall. (2 half days)Big difference.

Good luck.
L13

 

Re: twitching and doc contact

Posted by maxx44 on January 1, 2004, at 17:31:33

In reply to twitching and doc contact, posted by Lyrical13 on January 1, 2004, at 9:17:32

well put---'restless-leg' syndrome is well-known.if you search 'medicinal caanabis', which stops it cold, you will find the 1998 harvard abstract expressing strong regret that the legal aspects hinder research on this plant's known therapeutic uses. as for seroquel? barring 'NMS', no AP should be stopped abruptly. if your dr. is 'up-to-date', he'll know you must titrate down. why? abrupt cessation may produce the symptoms a neuroleptic was designed for---the schizophrenias. this appears a greater risk for 'affective disorder clients'---do not expect your dr. to be aware of this. 1st, bad drs. abound. you seem to have found a good one. 2nd, even great drs. are so busy treating clients all day, they simply don't have time to rush home, hit the net, and sacrifice their 'family or personal free-time' for your, and other's interest alone. furthermore, even if they did such, the blizzard of data is deep. as i've posted, a trial of the atypical neuroleptic risperdal clearly produced 'slow' 'atypical neurolepic malignant syndrome' in me. after 3 month's of incontinence, odd high fevers, and becoming so 'rigid', i could not stoop or cycle, i knew these symptoms were trouble. i titrated down on my own, and too quickly, and my bp1 became schizophrenia---for months i awoke to terror no bipolar may imagine. you don't want that. 2 years later 'atypical NMS' was finally recognised in the lit. only 3 months ago my shrink, who also teaches at the U of Virginia, returned from a 'dr. conference' which in great part focused on ANMS---a slower titration may have saved me the experience of 'temp' schizophrenia'---go easy,, good luck

 

re: atypical NMS

Posted by Lyrical13 on January 1, 2004, at 18:31:21

In reply to Re: twitching and doc contact, posted by maxx44 on January 1, 2004, at 17:31:33

thanks for the info re: titrating down on Seroquel. When my doc and I talked about the med change I asked about how we would d/c the seroquel and he said "just stop it". I will have to talk to him about the atypical NMS. I'd like to find out more about it before my appt and maybe have an article to reference or pass along (he seems like the type of doc who would be OK with this..he gives me info and tells me to check it out for myself...seems like he promotes active patient participation in tx decisions.)

So, to further that end...what does NMS stand for? Thanks
L13

 

re: atypical NMS

Posted by maxx44 on January 1, 2004, at 19:34:37

In reply to re: atypical NMS, posted by Lyrical13 on January 1, 2004, at 18:31:21

ok---seroquel is an atypical neuroleptic. basically a 'super-benzo'---zyprexa info sheets 1st termed it a 'thio-benzodiazapine'. if you've been on seroquel, even weeks, and if the dose is high enough to show effects, IMHO you'd best taper, as you must with a benzo---or you will see trouble. maybe your dr. knows something very new. or has a plan, such as countering the probable precipitation of even acute psychosis, in many, with a high dose of a non AP benzo for a month. then a short taper off it. but if you just quit and go bonkers and this dr. says, 'see there---you need this med'? walk. this data is all over the net---'supersensitive psychcosis', etc. look.
the usual sudden withdrawal (save NMS crisis)of any major or minor tranqilizer may be lethal. so people will be peeved with that statement of fact. poor, poor scary me! and i don't have time for 'spell-check.'---there's more to this, if you have interest, post back-----

 

Re: Anyone had success on Effexor XR?

Posted by biogurl on January 1, 2004, at 22:10:42

In reply to Re: Anyone had success on Effexor XR? , posted by Chandelen on December 31, 2003, at 0:38:23

I also take propronalol for anxiety. I am extremely shy and when I am around more than 4 people I start shaking and sweating and my blood pressure increases. My old doc (from when I still had insurance) prescribed it and I only take it when needed. It's also really great for public speaking. I had to do a biology seminar at school (i'm a bio major) and I took propronalol before it and I did great. I was hardly nervous at all when every other public speaking I had ever done had been horrible. I'm so happy he suggested this. He also told me to research it on the net.
Since then I turned 23 and don't have insurance through my dad anymore so I have this free insurance where I can NEVER see the same doc more than once. So I have to go over everything everytime I see a doc. It's ridiculous.

 

Re: Effexor XR - Some Advice Desperately Needed.HELP.

Posted by Johnlund on January 1, 2004, at 22:32:10

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP., posted by joeyD on December 31, 2003, at 8:09:23

> Hey guys sorry about taking up time here. I hope I'm posting in the right place. I have a few questions. I have just started taking 75 mg of Effexor XR about a week ago for GAD and mild depression. Since I started I have not been able to sleep, however I have been able to function surprisingly well. As of last night I have been having some extreme OCD symptoms!! I could not even think about going to sleep last night so I took 1mg of Klonopin and when I woke up this morning the OCD is still here but even worse! Its driving me crazy! I never had these feelings before and its really bothering me. BTW, they are not dangerous in any way to others or myself. Could the Effexor be causing this? Also, does this med generally cause extreme aggitation? I've been getting angry extremely easilly for a few days now. Sorry to bother you guys about this stuff but my doctor wont talk to me over the phone and my appointing is not until another two weeks. And yes, I am currently looking for a new one.
>
> Thanks in advance!!
>
> Joey


Joey;

First, you will probably feel irritable for the first view weeks. That is normal. Then about the third or fourth week you should feel a calm come all of a sudden. At least, that was my experience.
Second, take some klonopin to help you sleep for the first few weeks. The sleeplessness should pass after that.
Third, you will probably experience some sexual disfunction, or lack of sex drive. This is one of the bad side effects of Effexor. I take Viagra. That seems to help.
Fourth, don't give up on the Effexor until you have tried it for 2 months at least. It takes that long to get adjusted to it.

Take care;
John

 

Re: Anyone had success on Effexor XR?

Posted by maxx44 on January 1, 2004, at 22:51:59

In reply to Re: Anyone had success on Effexor XR? , posted by biogurl on January 1, 2004, at 22:10:42

the rediculous killing of minds when not appropriate, rather money-driven', that bothers me. if you may control the drug and use infrequently as intended---3 cheers. inderal? why do you think so many pop music icons have died from heroin? same deal. super-anxiety relief. right? or so they claim. put me to sleep for 26 hours--scripted to lessen lithium/imipramine 'tremor'. i'd still watch it and use only when a known need is overpowering.
it's like being a smoker---you'd best know cigs (a 'street-med as alcohol') or meds may be lethal and have 'cumulative' effects way down the line. if you close the deal, and infrequent inderal helps? great---start using it for every stressor, trouble you don't want to ever see, nor should you. IMHO.

 

Re: Effexor XR - Some Advice Desperately Needed.HELP.

Posted by maxx44 on January 1, 2004, at 23:20:05

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP., posted by Johnlund on January 1, 2004, at 22:32:10

re: john's well meant response---when you enter the realm of 'dangerous thoughts', as i did only hours after wellbu intake, you are experiencing 'pschycosis'---any reputable dr. should be told immediately and probably That med stopped. there are dozens you have to 'shop' thru. this is but one. 'one man's meat is another man's poison'. i don't feel john has been in your shoes. i have---scared the shit out of me, fear of 'loss-of-control' over my body, and 3 daughters and wife sleeping, at my mercy---sir, do you understand? sometimes you will get a med-reaction that makes you 'the mother in clearlake, texas'---it happens. ideas are not to be ignored. drugs which produce nasty ideations are not for you. or any such. obviously, giving any 'dangerous ideation' drug a continued trial is both irresponsible and potentially catastrophic. report these thoughts to your dr., or hit a good er, if it comes to that. don't end up 'film-at-11'. savvy?

 

re: atypical NMS

Posted by Lyrical13 on January 2, 2004, at 5:31:48

In reply to re: atypical NMS, posted by maxx44 on January 1, 2004, at 19:34:37

OK Maxx...scary but worth checking out. Personally I think all meds should be titrated off slowly to avoid bad effects. But I still don't know what the initials NMS stand for. I know Seroquel is an atypical antipsychotic and they really don't know what long-term effects it will have because it is much newer than other meds. I'll check out "supersensitive psychosis". NMS=???????

 

Re: joey d and effexor XR and your pdoc

Posted by helenag on January 2, 2004, at 17:03:15

In reply to Re: Effexor XR - Some Advice Desperately Needed.HELP., posted by joeyD on December 31, 2003, at 8:09:23

> Hey guys sorry about taking up time here. I hope I'm posting in the right place. I have a few questions. I have just started taking 75 mg of Effexor XR about a week ago for GAD and mild depression. Since I started I have not been able to sleep, however I have been able to function surprisingly well. As of last night I have been having some extreme OCD symptoms!! I could not even think about going to sleep last night so I took 1mg of Klonopin and when I woke up this morning the OCD is still here but even worse! Its driving me crazy! I never had these feelings before and its really bothering me. BTW, they are not dangerous in any way to others or myself. Could the Effexor be causing this? Also, does this med generally cause extreme aggitation? I've been getting angry extremely easilly for a few days now. Sorry to bother you guys about this stuff but my doctor wont talk to me over the phone and my appointing is not until another two weeks. And yes, I am currently looking for a new one.
>
> Thanks in advance!!
>
> Joey

Joey: Doesn't your pdoc have a nurse in the office that you can talk to??? Usually you can leave a message about meds with the nurse and she will talk to the doctor for you and call you back. Have you tried that?? If you just asked for the doctor without telling the office why, it is usually no wonder you wouldn't get a call back.
I find it very strange that you would receive no help with a med question or problem from a pdoc's office. Very strange. Try calling again and this time tell whomever answers the phone why you are calling (if you didn't before) and that you need someone to call you back asap. If you did do this and no one responded, try again. If you get the same result, it seems like this is quite an unusual office here.....hope you are feeling better soon. helen. and if you have no luck with this doctor, find a new one pdq!!!

 

re: atypical NMS

Posted by maxx44 on January 2, 2004, at 18:18:18

In reply to re: atypical NMS, posted by Lyrical13 on January 2, 2004, at 5:31:48

search 'neuroleptic malignant syndrome' (NMS), and 'atypical NMS'---when drs. speak of any neuroleptic they use a phrase, 'dopamine and/or dopamine serotonin' BLOCKADE---this is a misnomer as these drugs don't 'block' anything, rather Demolish the deep-brain production facilities and receptors of these key elements of 'self'. that's why those having used benzos or worse, neuroleptics, usually long-term but often even briefly, suffer the fate of always needing the drug. their born 'hardware' has been 'wiped'. scary? please, don't kill the messenger, as many would.

 

Re: Max, stop being so negative! » maxx44

Posted by Mercedes on January 2, 2004, at 21:28:06

In reply to Re: Anyone had success on Effexor XR? , posted by maxx44 on January 1, 2004, at 22:51:59

Geesh! you seem to have a negative response to everything. You respond and contradict others' 'good' or 'helpful' advice/intentions and manage to make everything so negative. This response and many you have posted are totally unacceptable, "killing of minds". Your opinion was not asked for. I know it's a 'free board' but for heaven's sake, don't scare people. We already have enough anxiety without having to hear our med's are "poisons".

If a person makes a comment on what med has worked for them, please don't say things like "death" or "letal". Like I said, we have enough anxiety/depression and don't need to hear sh*t like that. Keep those to yourself. IMHO

*************************************

> the rediculous killing of minds when not appropriate, rather money-driven', that bothers me. if you may control the drug and use infrequently as intended---3 cheers. inderal? why do you think so many pop music icons have died from heroin? same deal. super-anxiety relief. right? or so they claim. put me to sleep for 26 hours--scripted to lessen lithium/imipramine 'tremor'. i'd still watch it and use only when a known need is overpowering.
> it's like being a smoker---you'd best know cigs (a 'street-med as alcohol') or meds may be lethal and have 'cumulative' effects way down the line. if you close the deal, and infrequent inderal helps? great---start using it for every stressor, trouble you don't want to ever see, nor should you. IMHO.

 

Re: Max, stop being so negative! » Mercedes

Posted by Zellie on January 2, 2004, at 22:48:02

In reply to Re: Max, stop being so negative! » maxx44, posted by Mercedes on January 2, 2004, at 21:28:06

I, too, would like to see more encouraging talk here. Yes, we all have concerns...we surely can help one another in many ways...but I don't believe that any of us ought to take on the responsibility of trying to warn everyone about every imaginable thing that is either a real, a potential or a presumed hazard. I agree with Mercedes here.

Kindest regards,
Zellie


> Geesh! you seem to have a negative response to everything. You respond and contradict others' 'good' or 'helpful' advice/intentions and manage to make everything so negative. This response and many you have posted are totally unacceptable, "killing of minds". Your opinion was not asked for. I know it's a 'free board' but for heaven's sake, don't scare people. We already have enough anxiety without having to hear our med's are "poisons".
>
> If a person makes a comment on what med has worked for them, please don't say things like "death" or "letal". Like I said, we have enough anxiety/depression and don't need to hear sh*t like that. Keep those to yourself. IMHO
>
> *************************************
>
> > the rediculous killing of minds when not appropriate, rather money-driven', that bothers me. if you may control the drug and use infrequently as intended---3 cheers. inderal? why do you think so many pop music icons have died from heroin? same deal. super-anxiety relief. right? or so they claim. put me to sleep for 26 hours--scripted to lessen lithium/imipramine 'tremor'. i'd still watch it and use only when a known need is overpowering.
> > it's like being a smoker---you'd best know cigs (a 'street-med as alcohol') or meds may be lethal and have 'cumulative' effects way down the line. if you close the deal, and infrequent inderal helps? great---start using it for every stressor, trouble you don't want to ever see, nor should you. IMHO.
>
>

 

Re: Max, stop being so negative!

Posted by maxx44 on January 2, 2004, at 22:50:16

In reply to Re: Max, stop being so negative! » maxx44, posted by Mercedes on January 2, 2004, at 21:28:06

let dr. bob decide my printable content---i feel your response inappropriate, or perhaps you just don't read throroughly---either the clearly stated risks on every shrink-med, or my posts'. i only deal with what i know, from myself and very numerous others. this is serious biz---you wish me flippant? not likely. not in your interest. savvy?

 

Re: Max, stop being so negative!

Posted by maxx44 on January 2, 2004, at 22:58:31

In reply to Re: Max, stop being so negative! » Mercedes, posted by Zellie on January 2, 2004, at 22:48:02

this is a med-board. i won't pat your back---i will tell you the med-negatives abounding on the net and experienced---in hopes you do not 'find yourself' gone. i've said 'if it works,it works', but i address those showing problems. i consider your response as 'flameing'.

 

Re: Max, stop being so negative!

Posted by maxx44 on January 2, 2004, at 23:21:25

In reply to Re: Max, stop being so negative! » maxx44, posted by Mercedes on January 2, 2004, at 21:28:06

as i said---my concern centers on 'do no harm'. meds can and do. as i concentrate on those with negative symptoms should i look like 'George Burns' and be a comedian on a med-board? i have a 26 year-old daughter on zyprexa for 2 years. she has diabetes---you make 'light' of this? i've expressed positives on many things. but the potential of crisis or life-long dependency matter to me more than your opinion---which does matter and is well taken. if nothing's hurting you, fine. if it is, i'm going to report from the net, observed experience of many others, and myself--it is no more negative than advising Grand Canyon campers to carry a flashlight, when walking the edge, at night. savvy?

 

re: atypical NMS » maxx44

Posted by Larry Hoover on January 3, 2004, at 10:49:26

In reply to re: atypical NMS, posted by maxx44 on January 2, 2004, at 18:18:18

> search 'neuroleptic malignant syndrome' (NMS), and 'atypical NMS'---when drs. speak of any neuroleptic they use a phrase, 'dopamine and/or dopamine serotonin' BLOCKADE---this is a misnomer as these drugs don't 'block' anything, rather Demolish the deep-brain production facilities and receptors of these key elements of 'self'. that's why those having used benzos or worse, neuroleptics, usually long-term but often even briefly, suffer the fate of always needing the drug. their born 'hardware' has been 'wiped'. scary? please, don't kill the messenger, as many would.

Well, I have no intention in killing the messenger, but I hope you won't mind if I challenge your declarations, and seek further information from you.

Quite contrary to what you declare above, neuroleptic malignant syndrome is generally associated with any drug which binds to the D2 dopamine receptor. There are exceptions, and those cases are considered to be idiosyncratic (due to factors present in the individual).

The total incidence of NMS is estimated to be 2 cases in 1000 (for all antipsychotic meds), and is generally accepted to be substantially less for the newer, so-called atypical antipsychotics, although data have not yet been sufficient for a numerical estimate.

NMS occurs 2/3 of the time within the first week of treatment, and almost without exception, within the first 30 days of treatment. Moreover, with appropriate medical care, the condition is considered to be fully reversible, upon discontinuation of the offending drug. There seems to be a trait susceptibility factor at work, so that those subjects having had one such occurence are substantially more likely to have another.

For more details, see:
http://www.nmsis.org/general_information.shtml

The immediate occurrence of NMS (upon initiation of drug therapy) argues very much against your proposed "Demolish(ing of) the deep-brain production facilities and receptors of these key elements of 'self'", as does the immediate recovery therefrom. Moreover, neurotransmitters cannot, by any stretch of the language, be construed to be "key elements of 'self'".

Your experience with drugs in this class may well have been horrific, and I deeply sympathize with you. However, you cannot generalize from your experience to the population as a whole. In fact, despite more than forty years of observation and study of NMS, we still do not know what causes it, or why it strikes the individuals that it does.

I do appreciate that informed consent requires, obviously, that one become informed. However, disseminating hyperbole and exaggeration does not qualify. In the context of the experience of the population as a whole, NMS remains a rare occurrence. It is a risk of neuroleptic treatment (and a few other drugs, as well), and if patients read the information kit that should accompany any new prescription, they will be fully apprised of the symptoms of concern, as well as the need to seek emergency treatment should those symptoms occur. After one month has passed, one can reasonably stand down from that guarded stance.

Now, as to having the "hardware wiped".....

The hardware, receptors and neurotransmitters etc.???

I'm not even sure of what you speak of.

The only way that a permanent change can be effected is to have the DNA destroyed, or changed. All cells are constantly interacting with their environment. Everything outside an individual cell is environment to it.

Within a cell, everything is environment to the DNA.

The DNA actively modifies its environment, via mechanisms not yet known to us. Some genes will become more active, while others become less so, due to environmental clues. Unless the cell dies (Parkinson's disease is the death of very specialized dopamine-secreting cells in the substantia nigra, for example), it will respond to external clues in accordance with its own genetic complement.

If there is a sudden external change (drug initiation, or drug withdrawal, for example), there will be a lag time between the way the cell was set up to deal with the environment, until it can find a new comfortable way to deal with the environment. During that period of adaptation, there can be some (very) unpleasant experiences. In so many words, it takes time for the DNA to figure out what's going on external to it, and to adapt the cell to the new parameters.

Now, let's consider the use of benzodiazepines. Let's also assume they're used by someone with a reasonable argument for using them in the first place, e.g. anxiety interfering with their quality of life.

For many such people, long-term benzo use is the norm. But, over time, efficacy can diminish, or medical situations may develop, such that discontinuation of the med is required. (I'll ignore the presently commonplace benzophobia overcoming the medical establishment. That is an issue worthy of an essay, in and of itself.)

A person undergoing such withdrawal is very likely to have profound symptoms, characteristic of the opposite of the effects of the drug itself, so-called rebound phenomena. There may also be other unique effects of withdrawal.

Now, that person will not go back to being "normal" after withdrawal. They were, after all, experiencing quality of life (anxiety) issues in the first place. Moreover, it is entirely possible that their "disease" (I think the word is appropriate, as 'disease' arises from the Old French, diseasu, "not at peace"), can reasonably have progressed (the anxiety likely worsened over time, causing the individual to seek treatment initially, and aging has occurred during treatment), despite medical intervention, via benzos. There is ample reason to expect that such a person will be particularly uncomfortable after withdrawal of the benzo medication. To attribute such an experience to, how did you say it?, 'hardware' (having) been 'wiped', is without foundation, and smacks of fear-mongering.

Please do provide any information that you can about hardware wiping and demolished deep-brain production facilities, as I would very much like to become an informed consumer myself.

Regards,
Lar


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