![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 725 to 749 of 10407. Go back in thread:
Posted by JahL on March 31, 2001, at 10:37:05
In reply to Re: Started Effexor XR Today, posted by SLS on March 31, 2001, at 9:49:21
Posted by SLS on March 31, 2001, at 15:43:32
In reply to Re: Study » SLS, posted by JahL on March 31, 2001, at 10:37:05
Thanks Jah.
Like all other currently used antidepressants, Effexor isn't for everyone. I'm sorry it wasn't for you, Jah.
Since this has been such a long thread about such a critical topic, I decided to invest a little more bandwidth and post the entire article as it appears on the PR Newswire website.
It is important to note that the study concludes that:
1. Effexor gets more people well than SSRIs.
2. Effexor produces a greater improvement than SSRIs. More people experienced a complete remission of depression with Effexor.
Dr. Thase, the principal investigator, has authored or co-authored 180 articles appearing in the Medline database.
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New University of Pittsburgh Depression Study Shows Venlafaxine Significantly Superior to SSRIs
- Virtual Elimination of the Symptoms of Depression with Novel Antidepressant - Could Have Substantial Public Health Implications -PITTSBURGH, March 1 /PRNewswire/ -- Results of a new study published today in the "British Journal of Psychiatry" shows that significantly more patients with depression who were treated with venlafaxine (Effexor(R)) or venlafaxine extended-release capsules (Effexor XR(R)) become virtually symptom free than patients treated with selective serotonin reuptake inhibitors (SSRIs) or a placebo(1). The study demonstrated consistent evidence that remission rates with venlafaxine were approximately 10 percentage points higher than those observed with SSRIs. To put this in perspective, this represents a 30 percent increase in the probability of remission with venlafaxine vs. SSRIs. This difference is thought to be because venlafaxine is a selective serotonin and norepinephrine reuptake inhibitor, which may result in two modes of action.
Antidepressant efficacy traditionally has been measured by an ability to reduce depressive symptoms by 50 percent. This is the typical mandatory benchmark that has been established in order to gain approval by regulatory authorities like the U.S. Food and Drug Administration (FDA)(2). A higher standard of efficacy measurement is known as "remission," or the virtual elimination of all symptoms of depression. When patients achieve full remission they are less likely to relapse(3) and are fully restored to normal psychosocial functioning(4) -- in other words, they are able to return to activities previously enjoyed before the onset of depressive symptoms.
"For the millions of people who suffer from depression, the study results are very exciting," said Michael E. Thase, M.D., professor of psychiatry, University of Pittsburgh School of Medicine, and lead author of the study. "Given the high global prevalence of depression, coupled with its staggering associated costs, this difference represents a potentially tremendous clinical and economic advantage. This certainly is the strongest evidence yet that all antidepressants are not equally effective."
The new data comes from eight double-blind trials that were pooled to compare remission rates of 2,045 patients with major depressive disorder who were treated with venlafaxine or venlafaxine extended-release capsules, an SSRI, or placebo. In the study, overall venlafaxine remission rates were 45 percent, compared to 35 percent for SSRIs, and 25 percent for placebo (p< 0.001 for all comparisons).
"I struggled with depression for many years and tried many different antidepressants that simply were not working," said Shelia Singleton, a depression sufferer. "But Effexor XR was the one that saved my life and got me to fully recover from depression. I'm excited to hear about the findings of this study and maybe now patients who are not getting well with other medications will be motivated to seek better treatment, and at least give them hope that it is possible to lead a happier, more productive life."
As a selective serotonin and norepinephrine reuptake inhibitor, venlafaxine simultaneously effects both serotonin and norepinephrine neurotransmitters implicated in depression and in anxiety(5,6). The extended-release formulation of venlafaxine (Effexor XR(R)) is the first and only antidepressant approved by the FDA and 33 countries worldwide to treat depression and generalized anxiety disorder (GAD). GAD, the most common anxiety disorder, is a long-term condition marked by overwhelming, chronic, and excessive worry, anxiety, and tension that persists for at least six months. Effexor XR has the proven ability to work long-term to achieve and sustain remission in GAD and in depression, helping patients not only get relief from their symptoms, but also helping them to maintain a complete recovery from their disease.
Study Findings
Remission frees sufferers from the symptoms of depression and allows them to participate in and enjoy their normal activities. In studies of depression, it is determined clinically by a score of < ,= 7 on the 17-item Hamilton Rating Scale for Depression (HAM-D).*
Data from eight comparable randomized, double-blind studies were pooled to compare remission rates of 851 people with major depressive disorder who were treated with venlafaxine or venlafaxine extended-release, 748 patients who were treated with SSRIs (Prozac(R) (fluoxetine), Paxil(R) (paroxetine), and Luvox(R) (fluvoxamine)) and 446 patients treated with placebo (from four studies), for up to eight weeks.
Significant differences in final remission rates were observed between patients given venlafaxine and patients given an SSRI or placebo. The significant difference between venlafaxine and the SSRIs started at week two, whereas the difference between the SSRIs and placebo reached significance at week four. Additional analyses confirmed that the findings were not dependent on any one study, nor were they limited to any particular definitions of remission.
"I believe the dual-action mechanism of action conveyed by venlafaxine increases the chances of patients obtaining the best treatment outcome -- the ability to achieve remission. This, in turn, may enhance their chances of long-term recovery," said Dr. Thase.
About Depression
Major depressive disorders, which include depression, affect an estimated 340 million people worldwide(7). The World Heath Organization recently concluded that depression is the world's fourth greatest public health problem. If left untreated, the effects of depression can be devastating, robbing people of the energy or motivation to perform everyday activities and, in some cases, leading to suicide. Symptoms of the disorder include feelings of sadness or emptiness, lack of interest or pleasure in nearly all activities, and feelings of worthlessness or inappropriate guilt. In addition to the personal costs of depression, the disease also results in more than $40 billion annual costs in the United States alone due to premature death, lost productivity and absenteeism.
About The University of Pittsburgh School of Medicine
The University of Pittsburgh School of Medicine is consistently ranked among the nation's leading medical schools. It is one of the university's six Schools of the Health Sciences, which include the schools of Nursing, Dental Medicine, Pharmacy, Health and Rehabilitation Sciences and the Graduate School of Public Health. Their combined mission is to train tomorrow's health care specialists and biomedical scientists, engage in groundbreaking research that will advance the understanding of the causes and treatments of disease and to participate in the delivery of care as a partner with the UPMC Health System. Among the many areas for which its faculty and programs are internationally recognized are oncology, psychiatry, genetics, transplantation and public health.
REFERENCES
(1) "Remission Rates During Treatment with Venlafaxine or SSRIs" abstract,
Thase et al.
(2) Thase ME, Entsuah AH, Rudolph RI. "Br J Psych." Remission Rates During
Treatment with Venlafaxine or SSRIs". In Press.
(3) Judd LL, Akiskal HS, Paulus MP. "J Affect Disorder." The role and
clinical significance of subsyndromal depressive symptoms (SSD) in
unipolar major depressive disorder. 1997;45:5-18.
(4) Sulser F. J "Clin Psychiatry." Serotonin-norepinephrine receptor
interactions in the brain: implications for the pharmacology and
pathophysiology of affective disorders. 1999;60:213-214.
(5) Dubovsky SL. "J Clin Psych." Beyond the Serotonin Reuptake Inhibitors:
Rationales for the Development of New Serotonergic Agents. 1994.
(6) Brunello N, Racagni G. "Human Psychopharmacology." Rationale for the
Development of Noradrenaline Reuptake Inhibitors. 1998.
(7) World Health Organization. The Newly Defined Burden of Mental
Problems. WHO website: http://www.who.int/inf-fs/en/fact217.html.
Accessed September, 2000.* HAM-D is a common psychiatric scale on which the severity of depressive symptoms is measured to determine treatment efficacy.
SOURCE University of Pittsburgh School of Medicine
Posted by JaneB on March 31, 2001, at 16:40:20
In reply to Re: Study, posted by SLS on March 31, 2001, at 15:43:32
> >"Effexor XR has the proven ability to work long-term to achieve and sustain remission in GAD and in depression, helping patients not only get relief from their symptoms, but also helping them to maintain a complete recovery from their disease."
Is this "complete recovery from their disease" a recovery while using the medication or recovery to the extent that antidepressants are no longer necessary--is the illness cured??? I want to be cured!! Celexa is not taking the depression or anxiety completely away. Should I switch to Effexor? I know, ask my pdoc. But what is this study saying about being recovered (cured)? JaneB
Posted by JahL on March 31, 2001, at 18:10:50
In reply to Re: Study--Is the illness cured?, posted by JaneB on March 31, 2001, at 16:40:20
> > >"Effexor XR has the proven ability to work long-term to achieve and sustain remission in GAD and in depression, helping patients not only get relief from their symptoms, but also helping them to maintain a complete recovery from their disease."
> Is this "complete recovery from their disease" a recovery while using the medication or recovery to the extent that antidepressants are no longer necessary--is the illness cured???
There is no cure as such 4 depression-the best you can hope for is complete control of symptoms.
I think the 'complete recovery' refers to remission whilst *on* Effexor itself.
After a suitable period of time, some (lucky!) individuals can wean off ADs w/o reoccurrence of their depression. However you need only ask Scott to appreciate the potential pitfalls of discontinuing a med that works...
J.
Posted by Canuck on April 1, 2001, at 3:13:08
In reply to Can't decide. PLEASE help!, posted by Michele on March 27, 2001, at 13:20:29
> Hi everybody,
> I am trying to make a desion. I have been on effexor xr for 3 weeks. 37.5,75,150. I have not felt any POSITIVE from this yet.... but many side effects that are scaring the *#*# out of me. Is it possible to tell if a drug is going to work for you in this amount of time? I've never taken an AD before... and I think if I want to stop them, now is the time, before I'm on it too long? I'm pulling hair out of my head trying to decide what to do. I can stop now, with hopefully minimal effects... or hang on and see what happens? If it's not the drug for me, I'd rather stop now and get it over with, since I'm out of work for 2 weeks. Any advice would be GREATLY appreciated. I'm sooo tired of these side effects.. they are messin' with my mind!!!! Thanx guys....... MicheleHello Michele,
I started to see results at about the three week mark. My physician says it can take up to six weeks to see an improvement though. I am like you, I had never taken an AD before this med (or any med, for that matter). It is frightening to finally decide that you are at the point where you need outside help. I think if you are comfortable continuing the med, then do so, at least until you have reached the six week mark to see if it is really working for you. You should also consult your doctor and share you concerns with him/her. If you are truly not comfortable with taking the med, don't quit cold turkey. As you know from this sight, there can be severe consequences. Speak to you doctor, and he/she can help you taper off the med. Good like in your struggle. Thank you for your time.
Canuck
Posted by Canuck on April 1, 2001, at 3:22:09
In reply to Re: Another satisfied customer! » Canuck, posted by Seraphim on March 28, 2001, at 10:36:48
> Seraphim,
Your points are well taken. You are correct, I have not gone off the med and cannot contest to how my body will react. I will have to cross that bridge when I come to it. I will keep you posted when I do make that decision. Wish me luck! Thank you for your time and kind words. Take care.
Canuck
> > > >Canuck,
> I too wish you the best. I must say that I know none of us here would have wanted to do you or anyone else a disservice of any kind by speaking of the fear and suffering we have been, or are currently going through due to side effects and withdrawal. I am very glad you stumbled upon this discussion group. You are able to make an informed decision and hopefully will take the warnings about missed or late doses very seriously. I wish I had known to be more careful, it would have saved me a lot of pain. I truly think that most of us just feel that all of the information on Effexor, especially withdrawal (you have no idea how horrid it is), should have been disclosed to us prior to our decision to start taking it. That is what I would like to see happen. If you are feeling happy again, then I cheer you on! Happy and Healthy are what we are all striving towards. Good luck :-)
> Seraphim
> > > >
> > > > Just a quick note to say that I have had great results with Effexor XR. I did have a few side effects in the first three days. I had nausea for the first few hours after taking the drug. I also had a hard time sleeping for the first few nights, but I was having a hard time sleeping before the med anyway. And then there was the constant yawning that I could not control. (That could be guite comical depending on where I was.) But I am happy to say that all of that has ended now and I am feeling great. I am feeling more and more like my old self every day. I don't pretend to think that this drug will have the same effect on everyone, but it has done wonders for me. I do wonder, however; if the reason that there are far more unhappy people than happy ones posting on this web sight is because the happy ones aren't looking for a forum to sing Effexor XR's praises. If you are taking the medication and are having good results, why would you bother looking for a sight on the internet? I only found this sight purely by chance one night when I first started taking the med. Let me say, had I read many of the postings before I started taking the drug, I would not have taken it. This would have done me a great disservice. I have always just checked in on this sight and read the postings, but today I feel compelled to share my "good" Effexor XR story. Thank you for your time.
> > > >
> > > > Canuck
> > >
> > > Canuck,
> > > Once again, you are talking about FXR while you are "on" it, please don't be fooled it is the scariest thing I have experienced "GOING OFF" it. I loved it while on it, it did wonders for me. Information is good and you are right about this site with no one reporting good stuff. I would love to read just "ONE" positive about the withdrawals's.... JUST ONE! It might give me hope, but in the meantime, keep reading so you become aware. Our society likes the quick fix (as did I) so we tend to hide our head in the sand if it does the job, quickly. My life will never be the same (knowledge and appreciation for my previous good health)) as for my health, I pray everyday for a full recovery from this drug. I have other detailed info if yo haven't already read. Please don't dismiss what you read, these are real people, with real suffering going on. This site helped me tremedouly knowing that I wasn't the only one and wasn't going crazy.
> > > God Bless and I will pray for your success,
> > > Pamela
> >
> > I do not believe that I am being "fooled". My head is not hidden "in the sand". I spoke at length with my physician before starting this medication and she was very clear that I would experience side effects when coming off of the drug. I also spoke to a friend and also a co-worker who have both been on the med and are now both off of it. Both complained of extreme headaches when tapering off, but have had no other adverse reactions. I don't pretend to say that there are not patients who go through extreme withdrawl, but to be back to my old self again, I was willing to take the chance. I did not make this decision blind folded. I am extremely comfortable with my decision and when I feel strong enough to go off Effexor XR, I will do so with an open mind and a positive attitude knowing that I made my decision with my eyes wide open. Thank you for your time.
> >
> > Canuck
Posted by Canuck on April 1, 2001, at 3:40:36
In reply to Started Effexor XR Today, posted by Cam W. on March 29, 2001, at 21:04:08
> Today I start Effexor XR (37.5mg daily and increasing to at least 300mg or more - depending on response - over the next 3 months).
>
> Thank goodness I know the difference between case studies, case series, post marketing surveillance, restospective studies, naturalistic studies, randomized placebo controlled trials, and other types of articles written about medications and disease states. I also know the merits and limitations of each.
>
> Thank goodness I have extensively studied all aspects of all antidepressants available in Canada (and most of those available in other parts of the world).
>
> Thank goodness I understand physiology (physical and chemical processes in the body), pharmacology (preparation, properties, uses, and actions of drugs), pharmacodynamics (how an antidepressant acts in the body , including duration of response relative to plasma concentration), pharmacokinetics (including absorption, onset of action, distribution, biotransformation, metabolite action, and excretion route), and pharmacogenetics (including the effects and differences of antidepressant action in different people). Otherwise partial explanations of these factors involving a small subset of people who did not withdraw from the drug in a proper manner, might scare me into not taking this drug.
>
> Even if I do happen to get withdrawl symptoms while being weaned from this drug, I know of several strategies to minimize these withdrawl effects. Most of which have been posted several times on this site. In the past, this drug has not been understood as well as it is today, although I and my colleagues knew of the withdrawl syndrome and it's extent in a minority of people, for at least the past 3 years and we have dealt with it appropriately. Withdrawl syndrome still occurs in some of our patients, but this is almost always due to nonadherence to the treatment regimen.
>
> Since I know how to wean myself from this drug if and when need be, I am very confident the this drug has the ability resolve my depressive symptoms and PTSD so that I may be able to lead a more productive and "normal" life, again. I see this drug as a useful tool, not an evil demon.
>
> Sincerely - CamCam,
A positive attitude! I love it!
Canuck
Posted by Michele on April 1, 2001, at 3:59:42
In reply to Re: Can't decide. PLEASE help! » Michele, posted by Canuck on April 1, 2001, at 3:13:08
Canuck.. Hi...
Thanks for the advice.... I posted that last week, and I did continue to take it. I notice some small things.. but not a lot yet... but at least the side effects are gone. How long have you been on it?
>
> Hello Michele,
> I started to see results at about the three week mark. My physician says it can take up to six weeks to see an improvement though. I am like you, I had never taken an AD before this med (or any med, for that matter). It is frightening to finally decide that you are at the point where you need outside help. I think if you are comfortable continuing the med, then do so, at least until you have reached the six week mark to see if it is really working for you. You should also consult your doctor and share you concerns with him/her. If you are truly not comfortable with taking the med, don't quit cold turkey. As you know from this sight, there can be severe consequences. Speak to you doctor, and he/she can help you taper off the med. Good like in your struggle. Thank you for your time.
> Canuck
Posted by Quasibarbidoll on April 1, 2001, at 4:38:02
In reply to Re: The Tip of the Iceberg.............., posted by Quasibarbidoll on March 29, 2001, at 14:25:03
I may have missed some of the exchanges that Pam was involved in, but I KNOW She's frustrated and suffering. It's exasperating for someone to question the validity of a nightmare.
Withdrawel from effexor has been like an out of body experience. I went from strong/cogent to a foggy, crying, irritated, ANGRY mess for Months, with no idea what or how to get out of it. My Dr. could only helplessly, follow the existing protocol. I finally got out of it with Same' and a small dose of Prozac. (The Same worked better than the prozac) good luck to all!
Posted by Jacklyn on April 1, 2001, at 14:20:21
In reply to Anyone had success on Effexor XR? , posted by jp on October 24, 1999, at 14:59:14
Hello,
I have been on Effexor XR 150 mg. for about 3 years. Seven years ago I was diagnosed with severe Fibromyalgia...there were many days that I could not get out of bed because the pain and fatigue were so severe. I was and am a divorced, single parent who was unable to work. Getting my son to and from school was a challenge on many days. If it weren't for my son, I would have committed suicide, because my life seemed impossible to live. I was treated by a team that included an Internist, Psychiatrist, and Rheumatologist, and tried many combinations of medications unsuccessfully over a 4 year period. (I had negotiated medical insurance to be paid by my ex during the divorce proceedings because he could afford it, and I thank god for the medical and prescription coverage that I have.) I finally arrived at a combination of meds that has made my life manageable/bearable...Effexor XR 150mg each day, and 1 mg of Clonapin plus 100 mg of Trazadone every night. Yes, this is a lot of medication, and yes, there are side-effects, and yes, I hate being so dependent on meds. My life is much smaller than it was 7 years ago, and I am much bigger (a lot of weight gain). But I no longer have debilitating pain, or fatigue, and therefore have the emotional and mental resources to cope with life's ups and downs. I teach full-time, plus tutor, to make ends meet. I never go out at night, because I am worn out and in bed by 8 p.m. I used to be an athlete, and now I take walks when I can. I have brain fog, memory loss,
and vision problems, but as I am 45, I think that this is due to both age and the meds. I was very angry for the first few years that I was sick..I went from being a Type A personality to an invalid, and neither friends or family understood, or quite believed, what was happening to me. I have tried getting off the meds a couple of times, and I went through terrible withdrawal and got very sick, very fast. So a couple of years ago, I just surrendered. I am here for my son, I like my work, and I have a pain-free little life. If this it the best that I will ever have, I can live with it. Hope my experience helps someone.Jacklyn
Posted by Marilyn on April 1, 2001, at 15:50:26
In reply to To Pamela, posted by Fish on March 30, 2001, at 10:44:32
Hi Pamela,
Please contact me ! You have every right to be angry as many of us are. Please e-mail me at
[email protected]Marilyn
Posted by Marilyn on April 1, 2001, at 15:55:36
In reply to Re: Anyone had success on Effexor XR? , posted by Jacklyn on April 1, 2001, at 14:20:21
http://www.jeffersonhospital.org/news/show.asp?durki=7423
Marilyn
Posted by DavidHIFI on April 1, 2001, at 22:13:53
In reply to Re: Can't decide. PLEASE help! » Michele, posted by Canuck on April 1, 2001, at 3:13:08
Michele,
I just started, too. It's been a couple of weeks and I've decided to stay at 37.5 to see how it goes and so far, so good. Talk to your doctor, it sounds like you increased dosages pretty quickly for a drug widely seen to take as much as 6 weeks to kick in. Maybe you can taper back to 37.5 until your body gets used to it. Good Luck
Posted by Ryan on April 2, 2001, at 2:06:51
In reply to Are WE the real guinea-pigs?, posted by Marilyn on April 1, 2001, at 15:55:36
Hi
Just thought everyone should be aware that the SSRI"s have been shown to change the shape of serotonin receptors in rat brains after only 14 DAYS of extremely high doses. This was the result of a recent study. No one knows the consequences of this, if it even occurs in humans, or if the mutations are permanent. Common sense tells me these drugs could be dangerous. They elevate serotonin to ABNORMALLY high levels in the brain. It makes me extremely angry that these studies haven't been performed until now...decades after release. I have been on and off high doses of them for years. I just completely stopped Effexor XR 300mg per day when I saw this study. Some may say I'm overreacting, but that information should have been available BEFORE I began treatment. The drugs in the study were Prozac, Zoloft, Meridia, and Pondimin. I am now looking for other, more conservative ways of treating my depression,OCD, and social phobia. If anyone has any information that couuld help me find treatment please post.
Thanks
Posted by Seraphim on April 2, 2001, at 10:42:08
In reply to Are WE the real guinea-pigs?, posted by Marilyn on April 1, 2001, at 15:55:36
Thanks Marilyn. Scary stuff. If you come across more, please share it.
Also, I agree with you in your message to Pamela. I too am angry and feel betrayed by the doctors and drug companies I trusted with my life. The withdrawal I am going through is so awful. I can't wait to get this "poison" out of me completely. It's just so hard. I wish you the best. Take care.
Seraphim
http://www.jeffersonhospital.org/news/show.asp?durki=7423
>
> Marilyn
Posted by Canuck on April 2, 2001, at 14:59:16
In reply to Re: Can't decide. PLEASE help!, posted by Michele on April 1, 2001, at 3:59:42
Canuck.. Hi...
> Thanks for the advice.... I posted that last week, and I did continue to take it. I notice some small things.. but not a lot yet... but at least the side effects are gone. How long have you been on it?
> >
> > Hello Michele,
> > I started to see results at about the three week mark. My physician says it can take up to six weeks to see an improvement though. I am like you, I had never taken an AD before this med (or any med, for that matter). It is frightening to finally decide that you are at the point where you need outside help. I think if you are comfortable continuing the med, then do so, at least until you have reached the six week mark to see if it is really working for you. You should also consult your doctor and share you concerns with him/her. If you are truly not comfortable with taking the med, don't quit cold turkey. As you know from this sight, there can be severe consequences. Speak to you doctor, and he/she can help you taper off the med. Good like in your struggle. Thank you for your time.
> > CanuckHi Michele,
I have been on the med for about 4 months. I am hoping to only stay on it for about eight months in total. I had kind of set that goal in my mind when I started. I don't have long term depression, just a bout of short term depression...or so I hope. Take care.
Canuck
Posted by DavidHIFI on April 2, 2001, at 18:27:37
In reply to Re: Are WE the real guinea-pigs?, posted by Ryan on April 2, 2001, at 2:06:51
I thought EffexorXR wasn't a SSRI.
Posted by McGuyver on April 3, 2001, at 12:37:19
In reply to Re: Are WE the real guinea-pigs?, posted by Seraphim on April 2, 2001, at 10:42:08
Effexor for Hypocondria? I think not!
> Thanks Marilyn. Scary stuff. If you come across more, please share it.
>
> Also, I agree with you in your message to Pamela. I too am angry and feel betrayed by the doctors and drug companies I trusted with my life. The withdrawal I am going through is so awful. I can't wait to get this "poison" out of me completely. It's just so hard. I wish you the best. Take care.
>
> Seraphim
>
>
> http://www.jeffersonhospital.org/news/show.asp?durki=7423
> >
> > Marilyn
Posted by Quasibarbidoll on April 3, 2001, at 13:39:59
In reply to Re: Effexor for Hypocondria?, posted by McGuyver on April 3, 2001, at 12:37:19
Very nice sarcasm Mcguyver......walk a mile in someones shoes before you judge.
Effexor for Hypocondria? I think not!
>
>
>
>
>
>
>
>
>
>
>
> > Thanks Marilyn. Scary stuff. If you come across more, please share it.
> >
> > Also, I agree with you in your message to Pamela. I too am angry and feel betrayed by the doctors and drug companies I trusted with my life. The withdrawal I am going through is so awful. I can't wait to get this "poison" out of me completely. It's just so hard. I wish you the best. Take care.
> >
> > Seraphim
> >
> >
> > http://www.jeffersonhospital.org/news/show.asp?durki=7423
> > >
> > > Marilyn
Posted by JoniJ on April 3, 2001, at 15:18:27
In reply to Re: withdrawal, posted by Rhonda on April 28, 2000, at 7:17:12
I was lucky enough to have a friend on Paxil at the same time I was so all the funky side effects I was having he was having as well. My husband finally got to the point he couldn't handle my sexual dysfunction and disinterest. At this point I swapped the paxil for Effexor. I went cold turkey off Paxil and was immobilized due to possitional vertigo. I literally could not move my head. Effexor is not nearly as good for panic disorder as Paxil so I decided to just give the whole drug thing a rest. I tapered the dose, and although I did it slowly I still had what I called brain explosions, at one point so bad I had one every time my eyes went from one side to the other, buzzing in my ears, and the worst, which are persistant after 6 weeks off the drug, hot flashes and flop sweats. Discontinuing this drug should only be done when closely monitored by a doc. but it most certainly can be done. And dont expect the average MD to know ANY of this stuff.
Joni, free at last
Posted by Seraphim on April 3, 2001, at 15:28:32
In reply to Re: Effexor for Hypocondria?, posted by McGuyver on April 3, 2001, at 12:37:19
>I don't think I quite understand your implications. Why don't you spell it out for me? It seems to be your forte.
Effexor for Hypocondria? I think not!
>
>
>
>
> > Thanks Marilyn. Scary stuff. If you come across more, please share it.
> >
> > Also, I agree with you in your message to Pamela. I too am angry and feel betrayed by the doctors and drug companies I trusted with my life. The withdrawal I am going through is so awful. I can't wait to get this "poison" out of me completely. It's just so hard. I wish you the best. Take care.
> >
> > Seraphim
> >
> >
> > http://www.jeffersonhospital.org/news/show.asp?durki=7423
> > >
> > > Marilyn
Posted by Kym on April 3, 2001, at 21:32:43
In reply to Long term effects of Effexor/permanent , posted by Leo on February 13, 2001, at 11:55:34
> I have been taking Effexor since 1997. At first, I thought this was a wonder drug. I started feeling much better. Now, after all these years, I think I've been wrong. I just recently began to ween myself off of this drug. I have experienced all the withdrawl side effects but even more so, have experienced additonal effects of Effexor that have recently come to light and that may be permanent. I would like to caution all of you on this drug. I strongly reccemend that you look into this drug before you commit yourself to another perscription. Of the posts that I have read, many of you seem to be on very high doses of this drug. I'm not so sure that the dosage taken plays into what happens when you try to get away from this med. I have been taking only 37.5mg and the withdrawl effects are as severe as those of you taking those massive doses. My fear is for those of you that are are taking these large daily doses. I can't imagine what you will experience or what permenant damage has been done when you try to get off of this stuff. I have also determined, through my own personal experience, that Effexor isn't what you may think it is in the beginning. It masks things. It effects your thought process. It adversly effects
> your memory. As I fight my way out of the withdrawl and during the periods when the side effects don't have me flat on my back, I feel fantastic. I'm ambitious and motivated. I suggest that you go to some of the sights that appear to be uncovering the truth about this drug. I visited the effexorfx.com that someone else posted on this sight and found it to be right on the money with everything that is says. Don't waste your time with the others. I sincerely hope, for all of us that have been taking this drug that we haven't been some drug company's money making lab rats. I am going to launch an investigation into the drug and the company that developed and manufactured this drug. My reasons for doing this are not financial. I am a surviving cancer patient. I went through one year of pure hell being treated for that 15 years ago. I'll be damned if I'm going to let some drug company that has been hiding the truth about Effexor get away with possibly degrading the quality of my life any further than it already has been. Take some advice from someone who's been where you are. Get off this drug. Get you doctor to prescribe something else. Ask questions and get answers and then get well. I don't think Effexor is going to get you where you want to go.
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I agree with you totally, I tried to quit cold turkey 3 times until finally, I took only one pill every 3 days and let me tell you by then I was ready to just stop the "terrible" way I felt. But I stuck with it and after 2 months of that I went to 5 days for a month and then I just stopped altogether, I have been off now for 2 months but I still feel lightheaded and sick sometimes and I have gained 20 pounds, I have never had any kind of problem with weight and all of a sudden I can't seem to get rid of this weight, I am constantly bloated, which started when I started to quit, Does anyone have any idea, how long these "after effects" last?
Posted by Amy 5452 on April 3, 2001, at 22:19:08
In reply to Re: Effexor for Hypocondria? » McGuyver, posted by Seraphim on April 3, 2001, at 15:28:32
I started taking Effexor XR only a week ago at 37.5mg. Tomarrow I move up to 75mg. I have been battling depression for about 2 years and finally decided to give meds a try to help. At first I heard such great things about this drug and now to be honest, you all are scaring me with what could happen (which I understand in some cases is your intent) Is anyone happy with their results??? I am sorry for what some of you are going through and I wish you the best of luck, I just don't understand if the bad happens to everyone or only a small percent of the people who take this drug? Should I give Effexor a try and see how it works or try to switch to something else? Thanks for your help
Posted by Nailhead on April 4, 2001, at 2:46:14
In reply to Re: Case Studies......More FACTS to come...... » McGuyver, posted by Leo on March 29, 2001, at 12:21:43
I just started taking this two days ago. Im supposed to be taking 75mg a day, but i seem to taking it every 12-16 hours instead. The first day, i really didn't have the urge to smoke. I liked this, as I'm trying to quit anyway. However, yesterday and today, my habit was back to normal. I think it might have been the nausea... smoking made it worse. Can anyone give me any information or personal feelings on this? Thank you very much.
Posted by Quasibarbidoll on April 4, 2001, at 6:39:52
In reply to Curious, posted by Amy 5452 on April 3, 2001, at 22:19:08
I beleive everyone is different and react to drugs and withdrawel in their own way. I had no real "issues"(Felt fine) on the drug besides weight gain in a really ugly way. (Thick around the middle.)
I was given Effexor for Fibromyalgia. 37.5 mg then 75mg. When they tried to up the dosage, I was in another universe. eventually the drug seemed to sear off. I got off the drug at the behest of my Dr. who has a "better" drug for fibro, soma.
It's now been 6 weeks and I still struggling to regain my former cognitive thought processes and resiliance. I have had Raiki, massage, chiro etc to try and expedite this AWFUL process.My challenge is that I truly beleive I have lost memeory and cognitive skills. If I had it to do over: I would have declined my rheumatologists kind offer of effexor and gone straight to the body work. good luck!
Should I give Effexor a try and see how it works or try to switch to something else? Thanks for your help
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