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11+#946;-HSD1 inhbitors for anxiety

Posted by linkadge on August 16, 2018, at 10:41:28

11beta-HSD1 is an enzyme that converts cortisone to cortisol. By inhibiting 11beta-HSD1 you can lower cortisol levels.

A quick google search for 11beta;-HSD1 inhibitors reveled:

-green tea (medium)
-curcumin (strong)
-emodin

and others. I wonder if some of the antidepressant effect of curcumin is through a direct cortisol lowering effect.
I wonder if specific cortisol blockers would augment antidepressants? The HPA normalizing effect of traditonal antidepressants can take weeks, and often involves interaction with monoamines.

Linkadge

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URL: http://www.dr-bob.org/babble/20180728/msgs/1100372.html