Posted by bleauberry on April 9, 2018, at 13:25:32
In reply to CB1 agonism 5-ht1a autoreceptor desensitization, posted by linkadge on March 30, 2018, at 18:18:54
I don't know what this means clinically. In my experience I have not seen armchair quarterbacking pay off good dividends very often.
But I can tell you for sure there is high potential in marijuana for psychiatric patients. I know 2 people personally who were psychiatric basket cases, including psychiatric wards and institutionalization. They have nearly normal lives today - work, hobbies, everything - and their only medication is marijuana.
They failed meds, inpatient treatment, and everything. But their lives were almost fully restored rapidly - and still enduring now, years later - with marijuana.
It deserves note that their doses are high - they both smoke frequently during the day and they consume edibles also - their tolerance so high that they don't get high anymore, their eyes do not get red or glassy. They just get normal.
So while the armchair quarterbacking on cannabis and psychiatry is interesting to talk about, I have seen it work miracles that I did not see happen in psychiatry.
15% of the population has a gene that makes them susceptible to depression/anxiety/schizo from marijuana. But everyone else could find benefit.
imo
> https://www.ncbi.nlm.nih.gov/pubmed/22133541
>
> The sustained activation of monoaminergic neurons by cannabinoid drugs can also be related to changes in the function of presynaptic inhibitory α(2)-adrenoceptors or 5-HT(1A) receptors (autoreceptors and heteroreceptors), whose sensitivity is downregulated or upregulated upon chronic CB(1) agonist exposure.
poster:bleauberry
thread:1097856
URL: http://www.dr-bob.org/babble/20180331/msgs/1098040.html