Posted by SLS on August 26, 2015, at 22:20:25
In reply to wellbutrin combined with AP/AAP drugs, posted by Christ_empowered on August 26, 2015, at 20:10:05
> I've read on here that Haldol+Wellbutrin is a nightmare. I take Abilify+Wellbutrin, and its been good to me. What's the difference?
As a partial agonist of dopamine D2/D3 receptors, Abilify will stimulate these receptors when the concentration of synaptic dopamine is low. That's the idea, anyway. Perhaps the two drugs act synergistically, since Wellbutrin is supposedly a dopamine reuptake inhibitor.
> Do you think it affects the TD risk? Is it just a low potency stimulant, sort of like the poor man's Ritalin?
Abilify is not without risk of producing TD according to several anecdotal reports. However, it may be less apt to produce TD and more apt to produce akathisia than the other atypical neuroleptics.
> I've been taking it for a while, and my anxiety and weird mood swings within depression (if that makes sense) have both gotten better. I'm more stable overall and I have somewhat improved concentration and less agitation. Good times. But...why should an AD that's stimulating do a lot of things that SSRIs do, but without turning me into a zombie?Perhaps it doesn't matter too much which domino is tipped first by a drug, as long as the path of falling dominos reaches the same end-point.
> If Wellbutrin works this well, why aren't there me-too drugs for wellbutrin...maybe ones without the seizure risk?Wellbutrin is perhaps the least understood antidepressant. Even if there were a series of bupropion-like drugs synthesized, I doubt any drug company would be interested in developing a compound whose patent has already expired or that does not have sufficient therapeutic advantage.
> Thanks in advance.I really haven't offered you anything more than conjecture.
There is a drug called cariprazine that might be approved by the U.S. FDA soon. It acts much like Abilify, but is supposed to be more selective for D3 receptors. It might thus act more potently as an antidepressant and a therapy for the negative symptoms of schizphrenia. I'm hoping that the FDA decision comes within the next six months. It is my understanding that the FDA has acknowledged that cariprazine is safe and effective. They just wanted more data on dosing.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1081783
URL: http://www.dr-bob.org/babble/20150806/msgs/1081788.html