Posted by SLS on October 20, 2014, at 8:55:26
In reply to Re: My insomnia cure » linkadge, posted by Phil on October 20, 2014, at 8:24:39
> My doctor told me to take Melatonin three hours before bedtime. Whether he's right is a different story.
Believe it or not, there is some variability as to what time is best to take melatonin for improving sleep. Some people respond best to it when they take it in the early afternoon. There are actually quite a few internal "clocks" that are essential to maintain healthy circadian rhythms. (endocrine, neural, intracellular, etc.). These clocks interact with each other. Although the hypothalamic suprachiasmic nucleus is generally referred to as the "master clock", the timing of neuroendocrine release and suppression might be desynchronized in mood illness. I don't see anyone taking Rozerem (ramelteon), though. It acts as an agonist (fake melatonin) at M1 and M2 melatonin receptors. Perhaps the ratio of M1/M2 agonism is not properly balanced by Rozerem. It is conceivable, but I have not seen anything that would indicate this.
Lithium is unique as a psychotropic medication in that it can help correct the intracellular clocks that ultimately regulate biological cycles. It is thought that this might explain some of its therapeutic activity in bipolar disorder (and perhaps schizoaffective disorder).
But I digress...
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1072526
URL: http://www.dr-bob.org/babble/20141017/msgs/1072545.html