Posted by doxogenic boy on October 24, 2013, at 10:58:21
In reply to abilify questions, posted by marcus1968 on October 23, 2013, at 9:37:13
> Hello I have been given some suggestions to add abilify to my pooping out Lexapro... I am clueless as to what abilify even does at low dose to help augment an ssri. can anyone explain how this works? also anxiety is a big part of my problem (gad) so would abilify help that or hinder? od should I just try an snri (which I have never tried)always ssri's
Here is a study with aripiprazole (Abilify) as adjunctive therapy to paroxetine or sertraline:
http://www.ncbi.nlm.nih.gov/pubmed/22813840Prog Neuropsychopharmacol Biol Psychiatry. 2012 Dec 3;39(2):355-7. Epub 2012 Jul 17.
Comparison of the efficacy between paroxetine and sertraline augmented with aripiprazole in patients with refractory major depressive disorder.
Yoshimura R, Kishi T, Hori H, Ikenouchi-Sugita A, Katsuki A, Umene-Nakano W, Iwata N, Nakamura J.
SourceDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu 8078555, Japan. [email protected]
Abstract
OBJECTIVE:Only two-thirds of depressive patients respond to antidepressant treatment. In recent years, addition of an atypical antipsychotic drug to ongoing treatment with an antidepressant has been considered effective and well-tolerated. In the present study, we compared the efficacy between paroxetine and sertraline augmented with aripiprazole in patients with refractory major depression.
SUBJECTS AND METHODS:Twenty-four patients who met the DSM-IV criteria for major depressive disorder who did not at least two different classes of antidepressants were enrolled in the study. Nine were male and thirteen were female, and their ages ranged from 28 to 66 (mean±SD=39±12) years. Patients were prescribed paroxetine (n=11) or sertraline (n=13) for 4weeks. Then, those whose scores on the 17-item Hamilton Rating Scale for Depression (HAMD17) decreased below 50% received adjunctive therapy of aripiprazole for 4weeks.
RESULTS:Although the use of either combination treatment decreased the HAMD17 scores compared to the respective monotherapy, there was no significant difference in HAMD17 scores between the paroxetine plus aripiprazole group and sertraline plus aripiprazole group.
CONCLUSION:Aripiprazole augmentation therapy with paroxetine or sertraline was equally effective and tolerated in patients with refractory major depressive order.
Quote end.Abilify can cause anxiety and insomnia, so I would have tried adding Seroquel to Lexapro (or another SSRI) first. If that doesn't work, you may add Abilify (to an SSRI) instead.
- doxogenic
Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine
poster:doxogenic boy
thread:1052865
URL: http://www.dr-bob.org/babble/20130930/msgs/1052924.html