Posted by doxogenic boy on October 22, 2013, at 12:46:02
Hi.
In this thread I would like to hear from those of you who have experienced that long-term use of antidepressants has worsened your depression and/or made you treatment-resistant. Did you feel better before you started with antidepressants?
I am satisfied with my meds, but it seems that there are a lot who dont get better.
There is some research that indicates that antidepressants worsen depression for some antidepressant users.
http://www.ncbi.nlm.nih.gov/pubmed/20728491
Excerpt from abstract above:Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1593-602.
Epub 2010 Aug 20.
The mechanisms of tolerance in antidepressant action.
Fava GA, Offidani E.
There is increasing awareness that, in some cases, long-term use of antidepressant drugs (AD) may enhance the biochemical vulnerability to depression and worsen its long-term outcome and symptomatic expression, decreasing both the likelihood of subsequent response to pharmacological treatment and the duration of symptom-free periods.
Quote end.Do you feel antidepressants have had this effect on you? How did they change your condition, and how long had you used antidepressants when your depression worsened?
- doxogenic
Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine
poster:doxogenic boy
thread:1052784
URL: http://www.dr-bob.org/babble/20130930/msgs/1052784.html