Posted by SLS on October 13, 2013, at 7:30:38
In reply to Re: 450mg Effexor - seems to be helping slightly. Q » SLS, posted by TriedEveryMedication on October 13, 2013, at 1:22:44
> > Add Wellbutrin or nortriptyline?
> >
> >
> > - Scott
>
> Thanks, Scott.
>
> I'd love to add a tricyclic, but effexor blocks CYP3d6 I think which breaks down all of the TCAs.
>
> I added desipramine a couple of times at a lower effexor dose and it wasn't exactly fun.
>
> I guess wellbutrin is an option.
>Nortriptyline is generally "smoother" and more tolerable than desipramine.
I experienced an improvement while taking a combination of Effexor 300 mg/day and nortriptyline 75 mg/day. I think I could have benefited from going even higher with the nortriptyline. I am an extensive metabolizer (2D6). Perhaps you can start nortriptyline at 10 mg/day and go up slowly while using blood tests to guide you. I think it is doable.
Effexor 300 mg/day OR Pristiq 100 mg/day in combination with Wellbutrin 300 mg/day is worth a try in my estimation.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1052096
URL: http://www.dr-bob.org/babble/20130930/msgs/1052111.html