Posted by phidippus on August 28, 2012, at 20:03:21
In reply to help- trazodone stopped working, posted by novelagent on August 22, 2012, at 2:11:31
Mirtazapine is an antagonist/inverse agonist at the following receptors:[64][65]
5-HT1A receptor (Ki=18nM; IC50=1,000nM) [66]
5-HT2A receptor (Ki = 69 nM)
5-HT2B receptor (Ki = ? (~20-fold lower than for 5-HT2A/2C))[67]
5-HT2C receptor (Ki = 39 nM)
5-HT3 receptor (Ki = ? (similar to 5-HT2A/2C (mouse neuroblastoma cell)))[68]
5-HT7 receptor (Ki = 265 nM)
α1-adrenergic receptor (Ki = 608 nM (rat))
α2A-adrenergic receptor (Ki = 20 nM)
α2B-adrenergic receptor (Ki = ? nM (likely similar to α2A/α2B-adrenergic))[citation needed]
α2C-adrenergic receptor (Ki = 18 nM)
H1 receptor (Ki = 1.6 nM)
mACh receptors (Ki = 794 nM (rat))
Dopamine D1 receptor (Ki=4,167nM) [69]
Dopamine D2 receptor (Ki=1,460nM) [70]
Dopamine D3 receptor (Ki=5,723nM) [71]
Dopamine D4 receptor (Ki=25nM)In contrast to mirtazapine, the SSRIs, SNRIs, MAOIs, and some TCAs increase the general activity of the 5-HT2A, 5-HT2C, and 5-HT3 receptors leading to a host of negative changes and side effects, the most prominent of which include anorexia, insomnia, sexual dysfunction (loss of libido and anorgasmia),
In addition, mirtazapine's antagonism of the 5-HT2A and 5-HT2C receptors has beneficial effects on anxiety, sleep and appetite, as well as sexual function regarding the latter receptor
Eric
poster:phidippus
thread:1023891
URL: http://www.dr-bob.org/babble/20120818/msgs/1024360.html