Posted by Bob on January 5, 2012, at 0:08:09
In reply to Re: Adding Parnate and prazosin. » Bob, posted by SLS on January 4, 2012, at 23:39:33
> > I'm still lost. Is causing NE alpha-1 receptors to downregulate a desired effect
>
> Apparently, it is. It should reduce NE activity, thereby reducing anxiety.
>
> > Logically it would seem to me that if you are blocking the receptors it would reduce the available NE to the brain?
>
> Prazosin does not reduce the amount of norepinephrine neurotransmitter in the brain.
>
> When NE attaches to a receptor, that receptor is stimulated to perform a function (either excitatory or inhibitory). Blocking this receptor using an antagonist or using an inverse agonist serves to prevent this function. Prazosin is an antagonist at excitatory NE alpha-1 receptors, thus reducing the number of receptors available for stimulation.
>
> I hope this helps. Maybe I'm confusing things.
>
>
> - Scott
It would seem to me that the effect you're describing would possibly reduce anxiety, but might also take away energy to function as well.
poster:Bob
thread:1005781
URL: http://www.dr-bob.org/babble/20111226/msgs/1006372.html