Posted by SLS on December 27, 2011, at 21:02:49
In reply to Re: lithium 5-ht1b + gsk-3b » SLS, posted by linkadge on December 27, 2011, at 20:30:14
Thanks for this, Linkadge. I'll need to reread it a few dozen times in order for it to stick.
- Scott
> Gsk-3b inhibitors have *some* antidepressant effects. GSK-3b is increased by dopaminergics (d2 activation) (i.e. psychostimulants) and decreased by serotonergics. In mice lacking trytophoan hydroxylase, gsk-3b is upregulated. The behavioral dysregulation in these mice can be reversed with selective gsk-3b inhibitors.
>
> Schizophrenic symptoms appear to be ameleorated in mice with selective gsk-3b inhibitors.
>
> Also, gsk-3b inhibitors have substantial neurotrophic effects. Selective gsk-3b inhibitors mimic many of the trophic effects of lithium and valproate.
>
> I think I remember reading one study that said fluoxetine was a gsk-3b inhibitor. Oh here it is...It also shows that imipramine, clorgyline and fenfluramine indirectly inhibit gsk-3b.
>
> http://www.nature.com/npp/journal/v29/n8/full/1300439a.html
>
> Anyhow, gks-3b is an interesting target for certain mood disorders because it interacts with circadian genes, as well as the regulation of the 5-ht1b receptor, which is critical in the control of limbic serotonin.
>
>
>
>
>
>
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1005569
URL: http://www.dr-bob.org/babble/20111226/msgs/1005687.html