Posted by Tomatheus on November 8, 2010, at 7:39:58
In reply to Re: One person's argument for Escitalopram » Tomatheus, posted by ggggg123 on November 8, 2010, at 6:18:28
ggggg123,
My response to SSRIs was hardly a good one. I experienced rapid cycling on Paxil and Prozac and felt significantly more depressed than usual on Zoloft. The point that I was trying to make was that even though I never responded consistently to any SSRI, I did not experience any apathy, anhedonia, or zombie-like effects on the medications. Just because a person did not experience those side effects from SSRIs does not mean that their response was necessarily good.
Although I do not agree that nobody with severe clinical depression will respond favorably to an SSRI, I think that you have the right idea in stating that those with severe clinical depression tend to respond best to medications that target multiple neurotransmitters. I know that personally the only antidepressant that successfully treated my anergic depression (which used to be very severe and probably still would be if it weren't for all of my treatments) for more than a few days was Nardil. From what I understand, it is not unheard of for patients to go through one reuptake inhibitor after another with no success only to find success with an MAOI. Additionally, one review article that examined the effectiveness of the RIMA moclobemide found that moclobemide was as effective as the SSRIs, but less effective than the MAOIs Nardil and Parnate, which would seem to suggest that Nardil and Parnate are generally more effective than SSRIs.
I appreciate the time that you take to write your posts, and although I don't agree with everything that you write, I do think that you put forth some intriguing ideas and should continue to do so. I look forward to reading more of your posts.
Tomatheus
Diagnosed with schizoaffective disorder. Currently taking 5 mg Abilify, 12.5 mg Lamictal, 2.25 mg Hydergine, and four supplements.
poster:Tomatheus
thread:968886
URL: http://www.dr-bob.org/babble/20101107/msgs/969141.html