Posted by Conundrum on October 28, 2010, at 12:06:47
In reply to Re: Thinking of coming off meds » bleauberry, posted by Maxime on October 14, 2010, at 21:27:57
I agree with everyone else that nortriptyline is probably causing the weight gain.
Many people do not realize it, but nortriptyline is not only an antihistamine, but also at 5 HT2C antagonist, with an inhibition constant of approximately 7.0. Antagonizing the 5HT2C receptor can cause massive weight gain. For instance Zyprexa and Remeron block this receptor and are also antihistamines and both can cause huge weight gain.
Parnate due to its preference of MAO-B inhibition should increase stimulating hormones. Taking this along with adderall, I would imagine would cause a net weight loss, in the absence of nortriptyline that is.
Also nortriptyline can cause retention of water in the body which could be causing the puffyness, which is different from weight from fat.
I remember how you were a few months ago and you seem much better now. I wouldn't let someones comments about how you look derail the progress you have made.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. )
Country:USACurrently taking Lamictal, mirtazapine.
Does humor belong in depression?
poster:Conundrum
thread:965683
URL: http://www.dr-bob.org/babble/20101020/msgs/967228.html