Posted by g_g_g_unit on September 18, 2010, at 21:27:30
In reply to Re: Leg jerks on serotonergic meds. . . » g_g_g_unit, posted by ed_uk2010 on September 18, 2010, at 16:30:08
> 100mg isn't that low, clomipramine is powerful stuff. It can certainly be effective at 100mg, so I would avoid any further increases, at least for the next month or so.Ah okay. My impression was that 100mg is insufficient in treating OCD.
>
> Twitching of the legs seems to result from excessive increases in serotonin. It is particularly likely with combinations of more than one serotonergic drug. I think it is a sign that 100mg is more than enough.
>Hmm. There are accounts in the archives where people experienced twitching for a week or so on Lexapro, Effexor, etc., but then it subsided. However, would 100mg of clomipramine be providing far more serotonin reuptake inhibition than an equivalent therapeutic dose of, say, Effexor? I'm just curious because that was my psychiatrist's first recommendation to me and I'm wondering if I could bypass a lot of these intrusive s/e's by switching.
poster:g_g_g_unit
thread:962688
URL: http://www.dr-bob.org/babble/20100917/msgs/962945.html