Posted by Conundrum on September 15, 2010, at 22:05:47
http://www.ncbi.nlm.nih.gov/pubmed/9786103
Combination of clomipramine and nortriptyline in the treatment of obsessive-compulsive disorder: a double-blind, placebo-controlled trial.
Noorbala AA, Hosseini SH, Mohammadi MR, Akhondzadeh S.Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Iran.
Abstract
OBJECTIVE: There is growing interest in investigating noradrenergic functions in obsessive-compulsive disorder (OCD) because some antidepressants with strong effects on serotonin reuptake blockade fail to relieve obsessive-compulsive symptoms. We undertook a trial to investigate whether the combination of clomipramine with nortriptyline was more effective than clomipramine alone.METHOD: Thirty patients who met the DSM-IV criteria for OCD completed the study. Patients were allocated in a random fashion, 15 each to clomipramine 150 mg/ day plus nortriptyline 50 mg/day and clomipramine 150 mg/day plus placebo.
RESULTS: Although both protocols significantly decreased the scores of the Yale-Brown obsessive-compulsive scale over the trial period, the combination of clomipramine and nortriptyline showed a significant superiority over clomipramine alone in the treatment of OCD.
CONCLUSION: As this study indicates, a rapid onset of action is one of the advantages of this combination. This study supports further investigation of the noradrenergic-serotonergic hypothesis in OCD.
PMID: 9786103 [PubMed - indexed for MEDLINE]
Iatrogenic post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. (not a formal DX)
Country:USA
Currently taking Lamictal, mirtazapine, and abilify.
poster:Conundrum
thread:962550
URL: http://www.dr-bob.org/babble/20100908/msgs/962550.html