Posted by Conundrum on May 26, 2010, at 8:12:50
In reply to Re: Atomoxetine(Strattera) versus Reboxetine(Edronax), posted by SLS on May 26, 2010, at 5:20:35
I don't know either, seems like it would be a new combo on this board. I mean if two things work moderately well, why not combine them and see what happens? I think desipramine would keep her from getting too hungry and too tired. Mirtazapine would potentiate the amount of norepinephrine and dopamine released. Also to Helena24, its important to know that even selective reuptake of norepinephrine by desipramine increases dopamine 3 fold. Mirtazapine, also increases DA via its antagonistic effects at the 5 HT2A/C, 5HT3, and Alpha-2 adrenergic receptors. I think the worst thing that could happen with this regimen is it could be too stimulating.
http://www.springerlink.com/content/e860538255551m32/
Chronic desipramine and fluoxetine differentially affect extracellular dopamine in the rat prefrontal cortex
ianluigi Tanda1, Roberto Frau1 and Gaetano Di Chiara1
(1) Department of Toxicology and CNR Centre for Neuropharmacology, University of Cagliari, Viale A. Diaz 182, I-09126 Cagliari, Italy
Received: 8 December 1995 Accepted: 25 March 1996Abstract The effect of chronic administration of desipramine or fluoxetine (10 mg/kg IP once a day for 2 weeks) on extracellular noradrenaline, serotonin and dopamine in the rat prefrontal cortex was studied by transcerebral microdialysis. Chronic desipramine increased extracellular noradrenaline and dopamine by three-fold as compared to saline controls. Acute challenge with 10 mg/kg desipramine increased by more than three-fold extracellular noradrenaline and dopamine in saline controls, but failed further to increase extracellular noradrenaline and dopamine in rats chronically administered desipramine. Chronic fluoxetine more than doubled the extracellular concentrations of serotonin but failed to change the extracellular concentrations of dopamine as compared to saline controls. Challenge with 5 mg/kg fluoxetine while almost doubling extracellular serotonin and dopamine concentrations in saline controls, failed further to increase extracellular serotonin and did not change extracellular dopamine in rats chronically exposed to fluoxetine. In contrast, challenge with 10 mg/kg desipramine normally increased extracellular dopamine in rats chronically exposed to fluoxetine. Therefore, chronic fluoxetine is associated with normal presynaptic dopamine transmission in the prefrontal cortex as a result of tolerance to fluoxetine-induced increase of extracellular dopamine; in contrast, chronic desipramine is associated with an increase of pre-synaptic dopamine transmission in the prefrontal cortex up to a level that cannot be further elevated by acute desipramine challenge. The results suggest that prefrontal cortex dopamine plays a different role in the antidepressant properties, of desipramine and fluoxetine.
Post-SSRI syndrome: iatrogenic anhedonia, memory and concentration problems, sexual dysfunction. [NOTE no sadness or anxiety]
Location:USA
Currently taking 25mg Lamictal.
poster:Conundrum
thread:941507
URL: http://www.dr-bob.org/babble/20100524/msgs/948953.html