Posted by SLS on November 24, 2009, at 16:40:25
In reply to Re: lamotrigine, posted by ColoradoSnowflake on November 24, 2009, at 14:44:47
> I also think Parnate is kicking in my R.A. I have felt it since the git-go but the Parnate was working so well I felt it was worth it. As the R.A. gets worse and worse I'm beginning to wonder.
>
> Geeze, it's always something!
I'm really sorry to hear this.I have read that MAOIs can actually drive R.A. into remission. From your research, do any treatments worsen symptoms first and improve them later?
- Scott
--------------------------------------------Int J Immunopharmacol. 1983;5(4):353-7.
Remission of rheumatoid arthritis and other disorders of immunity in patients taking monoamine oxidase inhibitors.Lieb J.
Elevated levels of prostaglandin E2 (PGE2) play an important role in rheumatoid arthritis and other disorders of immunity. By inhibiting the release of arachidonic acid from cells, monoamine oxidase inhibitors (MAOI's) inhibit PGE2 synthesis. MAOI's appear to be capable of remitting the symptoms of rheumatoid arthritis and may have the potential to arrest it. MAOI's also appear to be effective in other disturbances of immunity in which excessive synthesis of PGE2 plays a role.
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Abstract
IgA nephropathy (IgAN), characterized by renal mesangial deposits of antibodies (of the IgA subtype), is the most common glomerulonephritis worldwide. The cause of IgAN is not known. IgAN can often lead to end stage renal disease (ESRD), and there is no known treatment proven to prevent ESRD in IgAN. Long term use of steroids or other immunosuppressant drugs carry severe toxicities and other risks. IgAN patients have high serum levels of tumor necrosis factor-α (TNF). Increased monoamine levels, via increased cellular cyclic AMP, can decrease TNF elaboration. Monoamine oxidase inhibitors (MAO-Is) have been found effective in case studies for a number of diseases, e.g. rheumatoid arthritis and Crohns disease, characterized by high TNF levels. Here I suggest that MAO-Is might be of utility in IgAN by decreasing TNF levels.
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poster:SLS
thread:926711
URL: http://www.dr-bob.org/babble/20091117/msgs/926858.html