Posted by rovers95 on October 19, 2009, at 14:29:55
In reply to Re: amisulpride-how to avoid insomnia etc.?, posted by Brainbeard on October 18, 2009, at 14:44:48
> > Having used amisulpride 25mg for 5 days I have had to quit due to increasing insomnia and irritability?
> >
>
> Weird. You take it in the morning, I presume? It never gave me insomnia, nor irritability. It does tend to boost my libido.
>
> > Does anyone think amisulpride could be effective at a quarter tab (6.25mg) and perhaps, as others have suggested the side effects of this drug may dissipate over time?
>
> Anything below 50mg seems to be effective when you're using amisulpride as a pro-dopaminergic drug (through blocking of presynaptic dopamine autoreceptors).
>
> Not only may these side-effects dissipate, the impressive boost of the first day(s) will dissipate sooner rather than later. After that, amisulpride's effects will be more subtle.
>
> In fact, to counter irritability and insomnia, you might be better off taking MORE than 25mg, perhaps even more than 50. If your dopamine is going overboard, amisulpride's higher dose D2-antagonism could quiet things down. At some point though, the benefits of presynaptic autoreceptor blockade will be lost. That point probably lies somewhere between 100 and 400mg.
>
> According to an age old thread here, if one continues using the drug, its effects may seem to disappear for a couple of weeks, but after that an anxiolytic (anxiety relieving) and moodlifting effect will emerge. I haven't used the drug long-term on a daily basis myself, so I can't corroborate this.
>Thanks for your advice....yeah i took it in the morning, its been nearly 5 days off it and my sleep still isnt yet back to "normal" and i still feel quite stressed out.
Bit scared to give a retrial but i think you could be right about going up rather than down, im also 6ft 6 and a reasonable build so perhaps i would need a larger dose!
But i think my ultimate goal would be to achieve downregulation of acetylcholine receptors (i believe mine are up-regulated) and improved dopamine through that!
Thanks again
Rover
poster:rovers95
thread:921165
URL: http://www.dr-bob.org/babble/20091012/msgs/921573.html