Posted by sowhysosad on May 20, 2009, at 5:45:00
In reply to Re: Avoid serotonergics after bad SRI reaction? » sowhysosad, posted by yxibow on May 19, 2009, at 23:41:19
> Zoloft is one of the few SSRIs known to cause things like akathisia because it has a slight blockade at D2.
That's interesting Jay. I understand depleted dopamine can play a part in akathisia, so maybe Zoloft makes it worse by blocking the D2 receptors?
> Not in my belief... there are a fair number of SSRI/SRI/SNRIs out there and you just may not be on the right one. They're definitely not all created equal.
My pdoc doesn't want to try me on a new med yet, which I think might be a good judgement call. I've also been off supplements for a few days and feel a little better.
> They can possibly after a while downregulate dopamine actually. Something that may have contributed to help in my case, but that's another story.
Dopamine release or receptor sensitivity? As I understand it, most SRI's (although obviously not Zoloft!) sensitise D2 receptors.
poster:sowhysosad
thread:896671
URL: http://www.dr-bob.org/babble/20090515/msgs/896763.html