Posted by bulldog2 on November 3, 2008, at 17:21:08
In reply to Re: Reuptake/ihibition/enzyme degradation » Questionmark, posted by JadeKelly on November 3, 2008, at 14:52:48
> > Good point, practically speaking. However-- and sorry to be technical, but-- Nardil does not affect GABA *reuptake* at all as far as we know, it inhibits the enzyme (GABA-transaminase I believe) that degrades GABA, the end result probably essentially being the same thing as if it inhibited its reuptake-- namely, more synaptic GABA available. So, you're still right that one may not need as much if any benzo while on Nardil, potentially.
>
> 1st, sorry for my limited knowledge, its why I'm here. Are you saying that reuptake inhibition, and inhibition (or destruction) of enzymes that degrade, have essentially the same end result? If thats an absurd interpretation, sorry!
>
> If not, why then do MAOI's work so much better than say, SSRI's? (I know, not true for many but a lot, me for one. MAOI's only AD ever touched my depression). Just curious. Thanks!
>
> Jade
>
>Maois work on the big three..se,ne and da...not necessarily in equal amounts but still that could be one reason why the seem to work better
poster:bulldog2
thread:860399
URL: http://www.dr-bob.org/babble/20081027/msgs/860597.html