Posted by Phillipa on September 6, 2008, at 19:20:31
In reply to Re: Glycine As a Primary Antipsychotic » ILADVOCATE, posted by Quintal on September 6, 2008, at 18:30:17
Sounds dangerous to me as compared to ketamine and pcp per wiki. Phillipa
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For the plant, see Glycine (plant).
Glycine
Systematic (IUPAC) name
aminoethanoic acid
Identifiers
CAS number 56-40-6
PubChem 750
Chemical data
Formula C2H5NO2
Molar mass 75.07 g/mol
SMILES NCC(O)=O
Complete data
Glycine (abbreviated as Gly or G)[1] is the organic compound with the formula NH2CH2COOH. It is the smallest of the 20 amino acids commonly found in proteins, coded by codons GGU, GGC, GGA and GGG. Because it has specialized structural properties in protein architecture, this compact amino acid is often evolutionarily conserved. For example, cytochrome c, myoglobin, and hemoglobin all contain conserved glycines.[citation needed] Glycine is unique among the proteinogenic amino acids in that is not chiral. Most proteins contain only small quantities of glycine. A notable exception is collagen, which contains about 35% glycine.[2] In its solid, i.e., crystallized, form, glycine is a free-flowing, sweet-tasting crystalline material.Contents [hide]
1 Production
2 Biosynthesis
3 Degradation
4 Physiological function
4.1 As a biosynthetic intermediate
4.2 As a neurotransmitter
4.3 As A Potential Antipsychotic
5 Industrial Uses
6 Antidumping tariffs
7 Presence in the interstellar medium
8 References
9 External links
[edit] Production
Glycine is manufactured industrially, either by treating chloroacetic acid with ammonia:ClCH2COOH + NH3 → H2NCH2COOH + HCl
or via the Strecker amino acid synthesis.There are two producers of glycine in the United States. Chattem Chemicals, Inc. and GEO Specialty Chemicals, Inc., who purchased the glycine production facilities of Hampshire Chemical Corp.[3] [4]
[edit] Biosynthesis
Glycine is not essential to the human diet, since it is biosynthesized in the body from the amino acid serine, which is in turn derived from 3-phosphoglycerate. In most organisms, the enzyme Serine hydroxymethyltransferase catalyses this transformation by removing one carbon atom; pyridoxal phosphate is also necessary:[5]Serine + tetrahydrofolate → Glycine + N5,N10-Methylene tetrahydrofolate + H2O
In the liver of vertebrates, glycine synthesis is catalyzed by glycine synthase (also called glycine cleavage enzyme). This conversion is readily reversible:[5]CO2 + NH4+ + N5,N10-Methylene tetrahydrofolate + NADH + H+ → Glycine + tetrahydrofolate + NAD+
[edit] Degradation
Glycine is degraded via three pathways. The predominant pathway in animals involves the catalysis of glycine cleavage enzyme, the same enzyme also involved in the biosynthesis of glycine. The degradation pathway is the reverse of this synthetic pathway:[6]Glycine + tetrahydrofolate + NAD+ → CO2 + NH4+ + N5,N10-Methylene tetrahydrofolate + NADH + H+
In the second pathway, glycine is degraded in two steps. The first step is the reverse of glycine biosynthesis from serine with serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase.[6]In the third pathway of glycine degradation, glycine is converted to glyoxylate by D-amino acid oxidase. Glycoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate in an NAD+-dependent reaction.[6]
[edit] Physiological function[edit] As a biosynthetic intermediate
Glycine is a building block to numerous natural products. In higher eukaryotes, D-Aminolevulinic acid, the key precursor to porphyrins, is biosynthesized from glycine and succinyl-CoA. Glycine provides the central C2N subunit of all purines.[7]
[edit] As a neurotransmitter
Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an Inhibitory postsynaptic potential (IPSP). Strychnine is a strong antagonist at ionotropic glycine receptors, whereas bicuculline is a weak one. Glycine is a required co-agonist along with glutamate for NMDA receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behaviour is facilitated at the (NMDA) glutaminergic receptors which are excitatory. The LD50 of glycine is 7930 mg/kg in rats (oral),[8] and it usually causes death by hyperexcitability.
[edit] As A Potential Antipsychotic
Dr. Daniel Javitt a clinical researcher had studied people who were addicted to PCP (angel dust) and Ketamine (PCP) (Javitt, DC, Negative Schizophrenic Symptomatology and the Phencyclydine (PCP) Model of Schizophrenia, Hillside Journal of Psychiatry 1987 9:12-35. Their brains had been damaged by the use of this drug. In studies, it was found that their glutamate receptors had been damaged. Since, use of PCP and ketamine creates psychosis similar to schizophrenia, it was hypothetisized that giving glycine to people with schizophrenia would potentially reduce their psychotic symptoms. In a controlled study people with schizophrenia who were given glycine had their symptoms reduced in a measurable sense, primarily in the area of negative and cognitive symptoms when used as an adjunct to current antipscyhotics. There have been some psychiatrists who have used it out of study as a primary antipsychotic with benefits on positive as well as negative and cognitive symptoms. Glycine's primary drawback is its required use in powdered format. However, as an NMDA receptor modulator, it is part of a class of antipsychotics in study that do not cause tardive dyskinesia or diabetes, the current long term side effects of dopaminergic antipsychotics as well as not creating extra pyramdial side effects (movement disorders), weight gain or sedation. These medications along with other new classes of medications in study may eventually replace the current antipsychotics which from Thorazine to Abilify have all been based on the dopamine hypothesis and in depleting the levels of dopamine create tardive dykinesia and other Parkinsonian movement disorders and potentially tardive psychosis which is still in study. Glycine, is part of a promising new class of treatment for schizophrenia that may promote a full recovery without debilitating physical side effects.
[edit] Industrial Uses
Glycine is used as a sweetener/taste enhancer, buffering agent, reabsorbable amino acid, chemical intermediate, metal complexing agent, and dietary supplement as well as in certain pharmaceuticals. [9]
[edit] Antidumping tariffs
Glycine imported from China to the United States has been subject to antidumping duties since March, 1995. [10]In 2007, a United States manufacturer of Glycine, GEO Specialty Chemicals, Inc. filed petitions requesting that antidumping duties also be imposed on Glycine imported from Japan, the Republic of Korea, and India. On September 7, 2007 the Department of Commerce announced its affirmative preliminary determinations in the antidumping duty investigations on imports of glycine from Japan and the Republic of Korea (Korea). On October 29, 2007 the Department of Commerce announced its affirmative preliminary determination in the antidumping duty investigation on imports of glycine from India.
[edit] Presence in the interstellar medium
In 1994 a team of astronomers at the University of Illinois, led by Lewis Snyder, claimed that they had found the glycine molecule in space. It turned out that, with further analysis, this claim could not be confirmed. Nine years later, in 2003, Yi-Jehng Kuan from National Taiwan Normal University and Steve Charnley claimed that they detected interstellar glycine toward three sources in the interstellar medium.[11] They claimed to have identified 27 spectral lines of glycine utilizing a radio telescope. According to computer simulations and lab-based experiments, glycine was probably formed when ices containing simple organic molecules were exposed to ultraviolet light.[12]In October 2004, Snyder and collaborators reinvestigated the glycine claim in Kuan et al. (2003). In a rigorous attempt to confirm the detection, Snyder showed that glycine was not detected in any of the three claimed sources.[13]
Should the glycine claim be substantiated, the finding would not prove that life exists outside the Earth, but certainly makes that possibility more plausible by showing that amino acids can be formed in the interstellar medium.
poster:Phillipa
thread:850659
URL: http://www.dr-bob.org/babble/20080903/msgs/850692.html