Posted by Marty on August 15, 2008, at 11:53:13
In reply to Re: finding agolmelatine » Marty, posted by Negcreep on August 15, 2008, at 8:59:25
> Yeah I agree with Marty. To be honest Id give it up trying to find combinations of other drugs to approximate the effect of Agomelatine. Its a totally new mechanism of action, and poly-pharmacy will usually just increase unwanted side effects.
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Exactly. and we dont' even start talking about the fact that what we know about the mechanism of action of a drug is very often suspected to be simplistic in theory and more complex in practice; many years from now we could find that Agomelatine act also on another familly of receptor/transporter/second messenger etc etc... You can't emulate a drug that you don't know well enough. Damn... even SSRI between them aren't often interchangeable depending of your condition. If Celexa can't emulate Paxil and Paxil can't emulate Prozac .. good luck emulating Agomelatine with a strong and dull atypical antipsychotic + the only other med that you know interact with Melatonin Receptors beside Agomelatine!> Also it seems as though getting hold of this drug before its approved will be next to impossible. Im not saying its not worth trying, but dont get your hopes up. Id say the best bet is think back through everything youve tried so far and find something that helps and has bearable side effects (trying to get by on a lower dose could help too) then just hold out untill this agomelatine is released.
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> It sucks but we're just gonna have to be patient.
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Did I read well about the possibility that Agomelatine approval in Europe could be in September 2008 ? I'm waiting for something like this since 16 years with intensive trial since 10 years... I, for one, can wait another couple months! .. but I know it's not the case for everyone and I feel sorry for them./\/\arty
poster:Marty
thread:835001
URL: http://www.dr-bob.org/babble/20080814/msgs/846380.html