Posted by NegCreep on July 24, 2008, at 12:35:58
In reply to Re: Agomelatine- Anyone tried it? Share your Info pls! » Negcreep, posted by Marty on July 24, 2008, at 10:29:33
Hi Marty....off the top of my head.....
I havent tried melatonin, as whenever I couldnt sleep on SSRIs Id either reach for Nytol, Zoplicon or "insert downer here". As a result Ive never really paid it that much attention untill now ive started reading about Agomelatine. I suspect that Melatonin has secondary action on other neurotransmiter recptors that could account for the depression you spoke of.
As for the anxiety you experienced from ingesting precursors like trytophan. I would put this down to the unselective action of natural serotonin. Ie your increasing overall levels of serotonin in all synapses and all types of serotonin receptors at once. Certain types of 5HT receptors are know to increase anxiety when stimulated. Indeed, this is why many ppl experience increased anxiety when first starting on an SSRI, although this reduces after about 2 weeks when the recptors desensitise to the increased serotonin in the synapse. Another thing to note is that selective serotonin reuptake inhibitors are called so because they are selective and only target a few types of 5HT recptors. This could account for improvement over precursors and older ' less selective' drugs.
So yeah now we have Agomelatine, something totally new. This drug primary acts on the M1 and M2 receptors as an agonist, helping you reset your body clock and get some sleep. I personally am not really interested in this aspect of the drug....yeah ok its cool if I sleep well but its not so much of a problem for me. Im much more interested in the drugs secondary acion as a 5-HT2C antagonist, and 5-HT2B antagonist. Its this action which indirectly accounts for the drugs alledged antidepressant/anxiolytic effects minus all the regular side effects of antidepressants to date....Brilliant! I just hope it lives up to the hype. Of the 2 reports Ive read online both were very positive, and I cant wait to give it a go. :)ps I wouldnt worry this aint no melatonin. :)
poster:NegCreep
thread:841653
URL: http://www.dr-bob.org/babble/20080718/msgs/841786.html