Posted by linkadge on July 2, 2007, at 18:43:48
In reply to Re: Gepirone has not dissapeared!, posted by Maximus on July 2, 2007, at 16:15:35
>I don't know if Gepirone is a potent Alpha 2 >antagonist? On paper it looks good but in a day >to day usage alpha 2 antagonists produce rage >and/or irritability on a lot of patients.
I think the ratio of 5-ht1a to alpha-2 is much higher for gepirone than for buspirone.
>Moreover several studies found that gepirone >increases plasma corticosterone levels, which >is "generally" bad.Short term administration of 5-ht1a agonists will increase cortistol, just as short term SSRI administration will increase cortisol via 5-ht1a.
Long term administration, supposedly has a favorable impact on HPA axis functioning. The cortisol response will downregulate, and the system will be less sensitive to environmental stressors. (at least in theory)
Linkadge
poster:linkadge
thread:767192
URL: http://www.dr-bob.org/babble/20070630/msgs/767241.html