Posted by Honore on June 30, 2007, at 9:56:55
In reply to Re: Nothing suggests Vitamin b destroys Nardil » Honore, posted by GWA on June 30, 2007, at 9:33:53
I If you could point me to an article that primarily concerns the chemical effects of vitamin b6 on Nardil, in general or specifically with respect to its possible metabolism into hydrazone, I'd be grateful.
I did acknowledge the point that you're making in my last responses. I specifically said that vitamin b6 could possibly affect the amount of nardil in the tissues-- but that this must, by inference, not usually interfere with nardil's effect.
(What I said:
"I see some articles which suggest that vitamin b6 can, in some extreme instances, somewhat reduce the amount of isozianid or even phenelzine in the tissues. This is mostly with megadoses of vitamin b6, used in cases of neurotoxicity or overdose. I see nothing that suggests that this occurs in normal dietary, or even vitamin supplemental, doses.
So whatever the effect, which you might have had as a result of a pretty rare condition or type of metabolism of nardil vs. vitamin b6, it's as yet not at all appropriate to counsel other people to avoid vitamin b6 when they take nardil. ")
I'm not denying that you might have had an usual reaction to vitamin b6 in the presence of Nardil, which could have cause the Nardil to become inactive. I'm also not denying that vitamin b6 might not --possibly-- in megadoses, reduce to some degree the effect of Nardil. (This remains, in my mind, to be established, but seems possible. However, that's different from its impact in normal doses or vitamin supplements)
The articles I've read disagree about whether vitamin b6 reduces Nardil (or isozionid, where vitamin b6 deficiency seems to more a more acute problem), or whether the peripheral neuropathy one finds with Nardil is produced entirely by loss of vitamin 6, and not at all by the Maoi.
You focus on one word in a sentence. I'm not a chemist-- although I do understand the concept of a chemical reaction, by the way.
I'd be happy to read any chemical text that bears directly and clearly on the question of the effect of vitamin b6 in reducing the effectiveness of Nardil as an AD, however.
In the absense of some concrete and openly argued scientific research connecting vitamin b6 with loss of AD effect in Nardil, I'd be very concerned about advising people to restrict vitamin b6.
Do you think it's possible you might have had a unusual reaction to vitamin b6? And that therefore others might not have the problem that you did?
Honore
poster:Honore
thread:765488
URL: http://www.dr-bob.org/babble/20070630/msgs/766850.html