sri, dopamine

Posted by med_empowered on April 9, 2007, at 23:52:53

In reply to Re: RLS, Akathisia + Dopamine D-2 receptors? » hgi698, posted by cache-monkey on April 9, 2007, at 18:45:28

well, sris sometimes cause TD. Apparently its been observed in long-term prozac and I think some effexor patients. Also, just as some researchers think patients "need" neuroleptics long-term only b/c of D2 supersensitivity secondary to long-term neuroleptic use, so too it appears that some patients "need" antidepressants long-term b/c of brain changes caused by long-term, high-dose antidepressant use. I personally think the dopamine effect with sris is probably also a big part of their effects--the mild stimulant/agitation from pumped up serotonin, the dulling from reduced dopamine, plus the additional effects of either mild sedation or mild stimulation from secondary effects on other neurotransmitters...SRIs seem to me to be kind of like low-dose neuroleptics PLUS (other milder effects). Just my thoughts.

Thread

Fellow pharm-geeks: a question about terminology cache-monkey 4/7/07
Re: Fellow pharm-geeks: a question about terminology » cache-monkey saturn 4/7/07
Re: Fellow pharm-geeks: a question about terminology » cache-monkey Larry Hoover 4/8/07
RLS, Akathisia + Dopamine D-2 receptors? cache-monkey 4/9/07
Re: RLS, Akathisia + Dopamine D-2 receptors? hgi698 4/9/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » hgi698 cache-monkey 4/9/07
sri, dopamine med_empowered 4/9/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » cache-monkey Larry Hoover 4/12/07
Re: sri, dopamine » med_empowered cache-monkey 4/12/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » Larry Hoover cache-monkey 4/12/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » cache-monkey Larry Hoover 4/13/07
Re: RLS, Akathisia + Dopamine D-2 receptors? linkadge 4/14/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » Larry Hoover cache-monkey 4/14/07

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