Posted by psychobot5000 on February 5, 2007, at 11:50:00
In reply to Re: Why don't they make a transdermal Nardil? » ed_uk, posted by Phillipa on February 3, 2007, at 19:10:15
> Why? Love PJ O
The reason is because Nardil is an unselective, irreversible inhibitor of MAO. It's inhibiton, on both types of the enzyme, is just too powerful. Even without sending the chemical through the digestive track directly, it would still snap up too much MAO.
It's selegiline's relative weakness (and reversability) at blocking MAO-a, combined with avoiding the gut (by skin delivery), that makes EMSAM so much safer about tyramine.
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