Posted by Larry Hoover on January 21, 2007, at 12:42:59
In reply to Re: pergolide, cabergoline: heart pathology via 5-, posted by linkadge on January 12, 2007, at 14:34:03
Jumping in......
Shows that fluoxetine is considered antagonistic at 5-HT2b, and that trazodone parent overwhelms agonism of mCPP:
http://circ.ahajournals.org/cgi/content/full/102/23/2836
A little off point, but an overview of cardiac/circulatory events even potentially associated with SSRIs does not reveal valvulopathy as an issue.
http://www.theannals.com/cgi/content/full/38/7/1197I also studied the complete 5-HT2b binding affinity table at PDSP http://kidb.cwru.edu/pdsp.php, and found no listed SSRIs with any appreciable agonism at this receptor.
Cabergoline was one of the most potent agonists listed.
Do you have other evidence, link?
Lar
poster:Larry Hoover
thread:720797
URL: http://www.dr-bob.org/babble/20070119/msgs/724802.html