Posted by halcyondaze on December 20, 2006, at 13:44:53
In reply to Halcyondaze ... IC?, posted by TrishP on December 20, 2006, at 6:14:00
I'm currently taking Parnate, which has basically cured my IC symptoms. I'm borderline, so tricyclic made me angry/irritable and have a history of anorexia, so the weight gain I experienced on various tricycics was not the best, either.
My primary symptoms were: bed wetting (happens only on meds, not at baseline), urinary frequency/urgency (started on meds, now happens at baseline too), and bladder pain (again, started on meds and now happens at baseline).
For a long time, I was delicately balancing on Nortriptyline or Desipramine and Seroquel and Trileptal. Raising the Seroquel/Trileptal caused bladder symptoms, so it meant titrting the TCA, which got annoying after a year.
Drugs that have caused nighttime urinary incontinence for me include: All SSRIs/SNRIs (you name 'em, I've been on 'em - even Cymbalta, supposedly effective for bladder symptoms, caused enuresis), Lamictal, Trileptal, Zonegran, Topamax, Seroquel, Risperdal, Zyprexa, Ambien, Lunesta.
The only drugs that have "cured" me of this are Adderall (could take anything with Adderall and it had zero effect on my bladder; however, I was abusing it in supra-therapeutic doses and it was not prescribed so not a real option for me in any sense) and Parnate (with which I now take Seroquel and Lunesta for sleep and have absolutely zero bladder problems.
I think that there is something curative about Adderall and Parnate; perhaps it has to do with dopamine. IC is so poorly understood but I have found research on amphetamines and IC:
1: Clin Exp Obstet Gynecol. 2005;32(4):247-9. Links
A novel highly effective treatment of interstitial cystitis causing chronic pelvic pain of bladder origin: case reports.
Check JH, Katsoff B, Citerone T, Bonnes E.
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.PURPOSE: To determine if a very effective therapy for idiopathic orthostatic cyclic edema--dextroamphetamine sulfate--would alleviate symptoms of chonic pelvic pain of bladder origin/interstitial cystitis. METHODS: Two women with interstitial cystitis that had been refractory to various therapies were treated with dextroamphetamine sulfate (20 mg/day) without any other treatment. The diagnosis of idiopathic edema was made by abnormal water load test and interstitial cystitis diagnosed by elevated scores on the pelvic pain and urgency and frequency symptom scale. RESULTS: Both patients quickly improved their bladder symptoms and all pain and urgency was gone within a week. The interstitial cystitis remained in remission as long as the women stayed on their medication. One woman proved Koch's postulates by stopping the medication because of forgetting it and symptoms resumed quickly only to disappear again upon resuming therapy. CONCLUSIONS: Dextroamphetamine sulfate can be a very effective therapy for recalcitrant cases of interstitial cystitis. Prospective placebo controlled studies are needed to determine what percentage of patients with this debilitating condition have concomitant idiopathic edema as determined by abnormal water load test and how well a larger series will respond to this novel therapy.
I'm thinking that there must be some correlation. At any rate, I'm just happy to have found a drug that enables me to live without IC controlling my life.
poster:halcyondaze
thread:713182
URL: http://www.dr-bob.org/babble/20061217/msgs/715229.html