Posted by dessbee on December 13, 2006, at 8:51:17
In reply to Re: Article on Biological Basis of Depression, posted by linkadge on December 12, 2006, at 20:23:36
I think the single gene theory in the article should not be taken too seriously.
The article is pro 'serotonin hypothesis'. I myself believe SSRI is not the true cure for depression, it only works partially through alleviating HPA-axis dysfunction.For sure, the etiology of depression is some evil gene/genes, an evildoer, that makes you vulnerable to stress. The pathogenesis of depression seems long term. HPA-axis is a feedback system that if not controlled can increase cortisol levels and cause hippocampus shrinkage, which aggrevate symptoms and stress sensitivity.
poster:dessbee
thread:712494
URL: http://www.dr-bob.org/babble/20061212/msgs/713202.html