Posted by Jay on October 21, 2006, at 9:02:29
In reply to Re: neuroleptics+depression..(and apathy), posted by linkadge on October 20, 2006, at 18:22:40
> Well, perhaps my statement was a bit of an overgeneralization. I suppose some people do find them effective for depression. Some people find that they make their depression worse.
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> Zyprexa was ok for sleep for me, but it seemed like such a high price to pay the next day, just for a med that got you to sleep.
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> One other consideration I heard somebody call into question was the following: While it is true that blockade of serotonin 5-ht2a/2c receptors will result in dopamine release in certain areas of the brain, the neuroleptic itself is going to block the some of the actions of that released dopamine, through dopamine receptor antagonism. So what is the net effect on receptor activation? I don't think we know.
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> Linkadge
Linkadge:I found Zyprexa works great with some of the more "stimulating" AD's, such as Effexor, but better with Prozac + Nortriptyline for me. Now, after a month or so use of it, up to the 10 mg mark, (which I take at bedtime), it seems to really help with my morning "dread", which is a kind of apathy. No, I am not no manic, "Whooopeee" type in the morning now, but I can get through things without feeling like ending it all right then and there, which was a symptom that has gone back many years. Even when I was a teen, early mornings where like swallowing shreds of glass while lugging around a 1 ton metal ball, and being peppersprayed right in the eyes at the same time.Add in the feeling like someone jared a pair of scissors into my back and kidneys, and made me drink a bottle of 120 proof vodka, and I think we are close.
Anyhow...you understand..I'm sure. :-) Even with the science, the mechanisms are at best, very loose and messy theories, obviously. Like you pointed out about the serotonin blockade and feedback loop. But, there is still some kind of "muking around" going on up there that seems to have some benefit, sometimes. The only evidence I honestly need, for anyone, is that if it relieves your symptoms, then it's done it's job. These meds are not mean't as, and are far from, a "cure". So I can have 5 out of 7 good days a week, rather then one single day, that's fine with me. But I would still try to reach for seven. Not "manic" days...just hum-ho days, with good and bad and all, but not falling to pieces. That is what I think some people gotta learn. Meds should not be used to induce some "manic" state, as I have seen happen on here.(And no, I don't mean with you, Linkadge. :)
Just IMHO...
Jay
poster:Jay
thread:696107
URL: http://www.dr-bob.org/babble/20061020/msgs/696488.html