Posted by willyee on August 21, 2006, at 11:46:16
This i came across when i have so much conflicting information of whether caffiene was of any benifit or counter benifit on the brain,unfortunaly i dont believe i have at my disposal the postive articles i collected,but this one here describes caffiene as a tolerant in ocd and toxic effect on the brain,this is not my opinion just a article with references i found on the net.
Editor:
With toxicity progressing, simultaneously or after manifesting as attention deficit hyperactivity disorder (ADHD), ongoing caffeine anaphylaxis continues poisoning the brain and generates the repetitive, obsessive behavior noted in obsessive-compulsive disorder (OCD). Obsessive-compulsive disorder commonly affects persons diagnosed with ADHD.
Several factors are involved with OCD. First, caffeine anaphylaxis poisons the prefrontal cortex. Obsessive-compulsive disorder is due to dysfunction of the prefrontal area. (1-3)
Caffeine, a monoamine oxidase inhibitor (MAOI), generates an increase of catecholamine (noradrenaline, adrenaline, and dopamine) production and delays catecholamine reuptake. Monoamine activity, (4), (5) including an increase in dopamine activity, (4) is believed involved with OCD.
Due to caffeine's MAOI properties, caffeine delays serotonin breakdown. A deficiency in serotonin metabolism is involved with OCD. (6), (7)
Caffeine anaphylaxis reduces cerebral oxygen. Anaphylactic shock causes circulatory failure, resulting in decreased blood flow and oxygen. Caffeine reduces cerebral oxygen, (8), (9) and hyperventilation, a symptom of anaphylaxis, (10-12) contributes to oxygen deprivation. Commonly, patients diagnosed with OCD suffer a decrease in cerebral blood flow. (13-15)
Ongoing caffeine anaphylaxis encourages a person to repeat thoughts. An overly stimulated poisoned brain generates thoughts of small dilemmas, generally not catastrophic, revolving repetitively in the mind.
The caffeine allergic individual never suspects a toxic brain. The chemical reactions of caffeine anaphylaxis masking allergic symptoms, and brain poisoning prevent a caffeine allergic person from recognizing symptoms of caffeine anaphylaxis, and memory impairment prevents the ability to recognize repetition. Persons with prefrontal cortex damage focus on the immediate.
Repetitively tying a sneaker until the loop seems perfect, a caffeine allergic person may think, "Not good enough, have to fix this loop--make it equal to the other one. Not good enough ...." A person may obsess about a relationship, or an action that goes against the individual's principles. An allergic person can easily dwell on how to get back at someone.
Like amphetamine and cocaine users, an allergically toxic person repeats actions. The person might lock and unlock a door, and lock it again, or, after leaving the house, dash back inside to see if the coffee pot, or iron was shut off.
Similarly, persons diagnosed with OCD dwell on issues which mentally healthy individuals may consider insignificant. They also repeat actions.
Obsessive-compulsive disorder usually begins in early adulthood and affects approximately 5 million Americans. (16) Comorbidity between OCD and the other mental disorders exists. Obsessive-compulsive disorder affects patients with anxiety, panic, bipolar disorder, depression, and schizophrenia.
Researchers believe that adolescents and young adults diagnosed with OCD who have previously used stimulants are more likely to develop bipolar disorder. (17) Symptoms of OCD accompany several physical disorders. Obsessive compulsion can accompany brain injury, (18-20) and drug toxicity. (21) Obsessive compulsive behavior affects stimulant users. (22), (23)
A high percentage of the world's population ingests caffeine in quantities that can produce substantial effects on the organs, including the brain. A toxin, caffeine presents a risk for generating psychological disorders. And chronic exposure to a drug presents the risk of developing an allergy.
Caffeine anaphylaxis fight or flight toxicity is a recently discovered disorder that generates a cascade of chemical imbalances. This cascade of imbalances accelerates neurotransmission, poisons the brain, and causes a progressively deteriorating dementia, which includes obsessive-compulsive symptoms.
The author wishes to thank the public library staff of Falmouth, Massachusetts.
References
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(2.) Leocani L, Locatelli M, Bellodi L, et al. Abnormal pattern of cortical activation associated with voluntary movement in obsessive-compulsive disorder: an EEG study. Am J Psychiatry 2001;158: 140-2.
(3.) Mac Master FP, Keshavan MS, Dick EL, et al. Corpus callosal signal intensity in treatment-naive pediatric obsessive compulsive disorders. Prog Neuropsychopharmacol Bio Psychiatry 1999;23:601-12.
(4.) Oades RD, Ropcke B, Eggers C. Monoamine activity reflected in urine of young patients with obsessive compulsive disorder, psychosis with and without reality distortion and healthy subjects: an explorative analysis. J Neural Transm Gen Sect 1994;96:143-59
(5.) McDougle CJ. Update on pharmacologic management of OCD: agents and augmentation. J Clin Psychiatry 1997; 58 (S12):11-7.
(6.) Molina V, Montz R, Perez-Castejon MJ, et al. Cerebral perfusion, electrical activity and effects of serotonergic treatment in obsessive-compulsive disorder. A preliminary study. Neuropsychobiology 1995;32:139-48.
(7.) Bastani B, Arora RC, Meltzer HY. Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients. Biol Psychiatry 1991;30:131-9.
(8.) Perod AL, Roberts AE, McKinney WM. Caffeine can affect velocity in the middle cerebral artery during hyperventilation, hypoventilation, and thinking: a transcranial Doppler study. J Neuroimaging 2000; 10: 33-8.
(9.) Mathew RJ, Wilson WH, Tant S. Caffeine-induced cerebral blood flow changes in schizophrenia. Eur Arch Psychiatry Neurol Sci 1986;235:206-9.
(10.) Stewart AG, Ewan PW. The incidence, aetiology and management of anaphylaxis presenting to an accident and emergency department. QJM 1996;89:859-64.
(11.) Theissen JL, Zahn P, Theisseri U, et al. Allergic and pseudo-allergic reactions in anesthesia. I: Pathogenesis, risk factors, substances. Anasthesiol Intensivmed Notfallmed Schmerzther 1995; 30: 3-12.
(12.) Revenas B, Smedegard G, Arfors KE. Anaphylaxis in the monkey: respiratory mechanics, acid-base status and blood gases. Acta Anaesthesiol Scand 1979;23: 278-84.
(13.) Busatto GF, Buchpiguel CA, Zamignani DR, et al. Regional cerebral blood flow abnormalities in early-onset obsessive-compulsive disorder: an exploratory SPECT study. J Am Acad Child Adolesc Psychiatry, 2001;40:347-54.
(14.) Lucey JV, Costa DC, Bun 4 et al. Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography. Psychiatry Res 1997; 74:25-33.
(15.) Crespo-Facorro B, Cabranes IA, Lopez-Ibor Alcocer MI, et al. Regional cerebral blood flow in obsessive-compulsive patients with and without a chronic tic disorder. A SPECT study. Eur Arch Psychiatry Clin Neurosci 1999; 249:156-61.
(16.) Ratey JJ. Shadow Syndromes. New York: Pantheon, 1997; 283-286.
(17.) DelBello MP, Soutullo CA, Hendricks W, et al. Prior stimulant treatment in adolescents with bipolar disorder association with age at onset. Bipolar Disord 2001;3:53-7.
(18.) Berthier ML, Kulisevsky JJ, Gironell A, et al. Obsessive compulsive disorder and traumatic brain injury: behavioral, cognitive, and neuroimaging findings. Neuropsychiatry Neuropsychol Behav Neurol 2001;14:23-31.
(19.) Childers NK, Holland D, Ryan MG, et al. Obsessional disorders during recovery from severe head injury: report of four cases. Brain Inj 1998;12:6134.
(20.) Max JE, Smith WL Jr, Lindgren SD, et al. Case study: obsessive-compulsive disorder after severe traumatic brain injury in an adolescent. J Am Acad Child Adolesc Psychiatry 1995;34: 45-9.
(21.) Bick PA. Obsessive-compulsive behavior associated with dexamethasone treatment. J Nerv Ment Dis 1983;171:253-4.
(22.) Koizumi HM. Obsessive-compulsive symptoms following stimulants. Biol Psychiatry 1985;20: 1332-3.
(23.) Kotsopoulos S, Spivak M. Obsessive-compulsive symptoms secondary to methylphenidate treatment (letter). Can J Psych. Feb. 2001. URL: http://www.cpa#apc.org/Publications/Archives/CJP/2001/FeblLetters4.asp. [Cited June 2003].
Ruth Whalen, MLT
592 Sandwich Road
E. Falmouth, Massachusetts 02536 USA
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