Re: Lithium mechanism and side effects?

Posted by linkadge on June 20, 2006, at 18:59:15

In reply to Re: Lithium mechanism and side effects?, posted by bipolarspectrum on June 20, 2006, at 18:42:02

There are many different mechanisms attributed to lithium. As bipolarspectrum pointed out, it affects the metabolism of inositol.
Some of the others are,
PKC inhibition,
GSK-3b decrease,
BDNF, NGF increase,
PIP2 modulation,
archonidic acid modulation,
sodium channel modulation,
5-ht1b autoreceptor antagonism,
glutamate stabilization (reuptake stabilization)
BCL-2 increase (neuroprotective protein)
MAP kinase modulation
The list goes on. Researchers believe certain targets, are more important to the theraputic action than others.
Linkadge

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Lithium mechanism and side effects? blueberry 6/20/06
Re: Lithium mechanism and side effects? bipolarspectrum 6/20/06
Re: Lithium mechanism and side effects? linkadge 6/20/06
Re: Lithium mechanism and side effects? bipolarspectrum 6/20/06
Re: Lithium mechanism and side effects? » bipolarspectrum Phillipa 6/20/06

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