Posted by linkadge on May 10, 2006, at 17:28:16
In reply to Re: suicide and AD effect » linkadge, posted by Larry Hoover on May 10, 2006, at 11:39:18
I understand. Psychiatry is at a crossroads at this point. There is always a lag period between the recognition of a problem, and an accurate explaination of that problem.
We know people will complain unsucessfully for a number of years about a given side effect, until an accepted explaination arrives.
The idea, for instance, that excessive 5-ht2c stimulation leads to sexual dysfunctions seems to come from the ability of 5-ht2c antagonists to reverse this behavior.
There are also many studies suggesting the roles of 5-ht2c in agitation, learning (declaritive memory), and appetite.
5-ht2c agonists are seem to be usefull appetite supressants, while antagonists like periactin are usefull for low appetite.
Experimentally administered 5-ht2c agonists also seem to cause extreme restlessness in normals and hence these receptors have been canditate for ADHD type conditions.
So no, I guess these ideas are not really all my own, I was simply trying to link these findings to some of common complaints SSRI's users have.
Linkadge
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URL: http://www.dr-bob.org/babble/20060510/msgs/642285.html