Posted by rod on April 2, 2006, at 5:35:46
In reply to Re: EMSAM-YEAH. SELEGINE-NOT SO GOOD. uh!?? » rod, posted by MARTY on April 1, 2006, at 12:46:08
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> > By using a patch you bypass first pass metabolism (the liver)... no metabolites means no nasty side effects because the metabolites are some amphetamines which very often cause anxiety and insomnia....
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> Bypassing First pass is a good thing indeed. But if SELEGILINE isn't worth much, what you got in the end is a 'poor antidepressant with less side-effects' and no MAOI diet ONLY on low dose. This would make the SELEGILINE patch an AD one step under Moclobemide.Well, i am neither a pdoc nor a psychopharmacologist but in my opinione the amphetamine metabolites totally cancel out the therapheutic effect of Selegiline. Good and restfull sleep is crucial in depression I think.
Anyway. Oral selegiline sucked, but the sublingual is great.... The Patch isnt available where I am..
over and out.
Roland
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> That said I think the coming of EMSAM is a very good thing overall. Even with all I said I'm very excited by this medical advance and I'm looking forward to see many people on this forum telling us it is a godbless for them.
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> Whatever I may think about EMSAM I wish I'll be prooved wrong in place and time.
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> Marty
poster:rod
thread:627408
URL: http://www.dr-bob.org/babble/20060329/msgs/627708.html