Posted by zeugma on April 1, 2006, at 14:17:15
In reply to Re: melatonin, REM, Parkinson's disease » zeugma, posted by linkadge on April 1, 2006, at 11:44:06
i'm afraid to take choline because I think my cholinergic system is completely messed up.
The issue of sleep and seizures is so complicated. For example it appears that norepinephrine is anticonvulsant, because NET KO mice had a lower seizure susceptibility.. but it seems one way they induce seizures in mice is by administering pilocarpine, which is a cholinergic agonist, so maybe it's predictable that NE blocks seizures in these mice.
And a friend with epilepsy is almost as religious about going to sleep early as I am, because he becomes increasingly seizure-prone with loss of sleep.
I read that valproate fails to exert an antiseizure effect in micelacking dopamine beta hydroxylase (the enzyme that synthesizes NE from DA).
-z
poster:zeugma
thread:626219
URL: http://www.dr-bob.org/babble/20060329/msgs/627517.html