Posted by blueberry on November 24, 2005, at 6:10:33
In reply to Re: Best med for complete lack of motivation? » blueberry, posted by Meri-Tuuli on November 24, 2005, at 3:57:28
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> > I'm not sure, but do you have the antipsychotic amisulpride (also known as deniban or solian) in your country?
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> Very interesting.....I'm going to add it to my list of things to try and ask the doc for. How does it differ from say, the stimulants etc which are involved with dopamine?How does amisulpride differ from stimulants? Actually, quite a bit. Stimulants create an accelerated release of dopamine and norepinephrine and a little serotonin, and also have dopamine and norepinephrine reuptake inhibition. And all this goes on in many parts of the brain and body.
Amisulpride only creates an accelerated release of dopamine, with no effect at all on norepinephrine or serotonin, and no reuptake inhibition. And this goes on in only very specific parts of the brain, in the mesolimbic area, associated with mood, pleasure, and motivation. It has no effect anywhere else.
St Johns Wort can be dangerous with other meds because it either increases or decreases the blood levels of other ongoing meds significantly, either causing adverse reactions from increased plasma levels or decreased efficacy from decreased plasma levels. Sjw affects the metabolism significantly for many meds, partially through liver enzyme activity and partially through gut enzyme activity. Amisulpride however I think would be safe, because it is not broken down in the liver, and much of it is actually passed through urine as unchanged drug.
poster:blueberry
thread:581526
URL: http://www.dr-bob.org/babble/20051119/msgs/581827.html