Posted by cache-monkey on March 29, 2005, at 14:05:59
In reply to Please help me if you've taken trazodone ........., posted by ed_uk on March 28, 2005, at 19:18:36
Hi Ed,
You mention in the PS that you're also interested in nefazodone. I took that as monotherapy for about 6 months. I did not find it very beneficial psychiatrically. Well, that's an understatement: it made me *more* anxious, agitated, and dysphoric.
However, I found it very pro-sexual. Almost as much as Wellbutrin was for me.
But, I think that for me both the paradoxical worsening of symptoms and the strong pro-sexuality with nefazodone might be a function of my liver enzymes. I'm an intermediate metabolizer for CYP-2D6, which breaks down mCPP, one of the metabolites of trazodone/nefazodone. (mCPP is known to be an anxiogenic and increases male sexual function, largely due to its agonism of the 5-HT2C receptor.)
Don't know if this helps, but I thought I'd post my experience anyway.
Best,
cache-monkey> .........preferably on its own.
>
> I would like to know, from your personal experience (rather than out of a textbook or pubmed LOL) what sexual side effects you got from trazodone?
>
> Thank you,
> Ed.
>
> PS. I would also like to hear from people who've taken nefazodone (Serzone).
poster:cache-monkey
thread:476896
URL: http://www.dr-bob.org/babble/20050326/msgs/477250.html